Severe complications of 5-fluorouracil and cisplatin with concomitant radiotherapy in inoperable non-metastatic squamous cell oesophageal cancer after intubation—Early termination of a prospective randomised trial

Development of severe complications caused by stent placement followed by definitive radiation therapy for T4 esophageal cancer

“…5,7,9 The reason for the increased risk of complications in patients with prior radiation and/or chemotherapy is likely multifactorial. The expansive force of an expandable stent may cause complications such as bleeding, perforation, fistula formation, and chest pain.…”

Oesophageal stenting

“…Alberts et al randomized 20 patients with inoperable squamous cell carcinoma to 5-fluorouracil and cisplatin with concomitant radiotherapy after stent placement or oesophageal intubation alone [113]. A survival advantage was evident in the stent-alone patients compared to those who had combined therapy (19 versus 11 weeks); consequently the trial was terminated early.…”

“…Stenting may be used as an adjunct to these or may be employed when they have failed. Several centres have examined the effects of various combinations of each [98,[111][112][113][114][115][116][117].…”

Treatment for locally advanced esophageal carcinoma complicated by fistulas: Case report

“…Alberts et al reported lethal complications including a major perforation and 3 early deaths in cases with concurrent chemoradiotherapy after intubation was used in patients with advanced, inoperable squamous cell carcinoma of the esophagus. 17 The perforation was considered to be caused by the mechanical pressure of the prosthesis. In this study, 1 of the 3 cases was complicated with an esophagoaortic fistula.…”