Severe Community-acquired Pneumonia Due to<i>Staphylococcus aureus</i>, 2003–04 Influenza Season

Hageman, Jeffrey; Uyeki, Timothy M.; Francis, J. Sullivan; Jernigan, Daniel B.; Wheeler, J. Gary; Bridges, Carolyn B.; Barenkamp, Stephen J.; Sievert, Dawn M.; Srinivasan, Arjun; Doherty, Meg; McDougal, Linda K.; Killgore, George; Lopatin, Uri; Coffman, Rebecca; MacDonald, J. Kathryn; McAllister, Sigrid K.; Fosheim, Gregory E.; Patel, Jean B.; McDonald, L. Clifford

doi:10.3201/eid1206.051141

Cited by 357 publications

(314 citation statements)

References 27 publications

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“…Classical clinical findings strongly suggestingthe diagnosis include haemoptysis, hypotension, "flu-like" illness myalgia, chills, fever of 39°C or above, tachycardia >140 beats/min, diarrhoea and vomiting (may be due to associated toxic shock) (7,3). CXR findings include bilateral multilobular infiltrates on chest X-ray, usually accompanied by abcess, recurrent pneumothoraces, pneumatocele, pleural effusion and later cavitation (1,7,8). Laboratory investigations that are helpful in confirming the diagnosis include, Gram stain of sputum reveals gram-positive cocci in clusters, leukopenia, high CRP level, negative pneumococcal and legionella antigen (1).…”

Section: Discussionmentioning

confidence: 99%

A case series of necrotizing pneumonia due to community acquired MRSA

Sandakumari

Pilapitiya

Dahanayaka

et al. 2014

Anuradhapura Med. J.

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Community-acquired pneumonia (CAP) due to Methicillin Resistant Staphylococcus Aureus (MRSA) is uncommon. In this case series, wedescribe four young immune-competent healthy males presenting with severe respiratory distress progressing to necrotizing pneumonia. All required ventilation and recovered without sequelae. One patient developed myositis and the other three developed pleural effusions and pneumothoraxes; two of them needing intercostal tube (ICT) insertion and drainage.These cases highlight community acquired MRSA in developing countries where antibiotics are frequently used empirically with little laboratory guidance.

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Section: Discussionmentioning

confidence: 99%

A case series of necrotizing pneumonia due to community acquired MRSA

Sandakumari

Pilapitiya

Dahanayaka

et al. 2014

Anuradhapura Med. J.

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“…The incident occurred during influenza season, and RT-PCR for influenza A and B was not performed. Influenza infection has an important role in MRSA infection (20), and thus complicating effects from influenza infection cannot be completely excluded.…”

Section: Discussionmentioning

confidence: 99%

Necrotizing Pneumonia in the Community

et al. 2012

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A 62-year-old man presented with general fatigue. He was diagnosed with septic shock and severe pneumonia. The sputum at admission yielded methicillin-sensitive Staphylococcus aureus (MSSA) strain and methicillin-resistant S. aureus (MRSA) strain. Despite antibiotic treatment, he did not improve. A chest computed tomography (CT) revealed multilobar cavity lesions. Only MRSA strain was confirmed at that time. We diagnosed him with necrotizing pneumonia. Despite treatment with vancomycin, his pneumonia worsened and he died. At autopsy, many gram-positive cocci were observed in the lungs. The clinical presentation of our patient was different from typical CA-MRSA-mediated necrotizing pneumonia.

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“…Risk factors for S aureus pneumonia include intravenous drug use, diabetes, renal failure and recent infection with viral pathogens (14)(15)(16). It has been postulated that viral infections preceding S aureus pneumonia can lead to severe necrotizing pneumonias requiring admission to the intensive care unit and mechanical ventilation, and is associated with significant mortality (17,18).…”

Section: Discussionmentioning

confidence: 99%