Severe Combined Immunodeficiency Signalized by Eosinophilia and Lymphopenia in Rotavirus Infected Infants

Hennewig, Ulrike; Schulz, Ansgar; Adams, Ortwin; Friedrich, Wilhelm; Göbel, U; Niehues, Tim

doi:10.1055/s-2007-985877

Cited by 8 publications

(7 citation statements)

References 9 publications

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“…The majority of patients described so far suff ered from opportunistic infections and failure to thrive within the fi rst 6 months of life. Our patient presented several times with classical warning sign for a SCID in a diff erential blood count: a profound lymphopenia of less than 1 500 lymphocytes / μ l. So, as stressed by campaigns to raise the awareness for SCID, also in our patient the diagnosis of SCID could have been established by the thorough analysis of a peripheral diff erential blood count [9] . In addition over all immunoglobulins were within normal range except for elevated IgA, IgG2 and IgE.…”

Section: Treatmentmentioning

confidence: 60%

“…The dysfunction of the T cell compartment can be associated with B cell defi ciency and NK cell defi ciency or both. Diff erent forms of SCID can be characterized by the immunological phenotype and a corresponding underlying molecular defect [1,6,9,11] . The T-B-NKphenotype of SCID is usually caused by adenosine deaminase defi ciency or purine nucleoside phosphorylase defi ciency [10] .…”

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confidence: 99%

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Delayed Onset of (Severe) Combined Immunodeficiency (S)CID (T-B+NK+): Complete IL-7 Receptor Deficiency in a 22 Months Old Girl

Roßberg¹,

Schwarz

Meisel³

et al. 2009

Klin Padiatr

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Section: Treatmentmentioning

confidence: 60%

mentioning

confidence: 99%

Delayed Onset of (Severe) Combined Immunodeficiency (S)CID (T-B+NK+): Complete IL-7 Receptor Deficiency in a 22 Months Old Girl

Roßberg¹,

Schwarz

Meisel³

et al. 2009

Klin Padiatr

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“…Bei jedem Verdacht auf einen Immundefekt müssen ein mikroskopisch differenziertes Blutbild angefertigt und die IgG-, IgA-, IgM-und IgE-Spiegel be- Eine Eosinophilie und/oder die Erhö-hung von IgE können auf Immundefekte wie SCID (Eosinophilie in Fall 1, IgE-Erhöhung in Fall 2), Wiskott-Aldrich-Syndrom, Hyper-IgE-Syndrom, IPEX-Syndrom ("immunodysregulation polyendocrinopathy enteropathy X-linked syndrome") oder Comèl-Netherton-Syndrom hinweisen [1,4,13,21]. Eine Thrombozytopenie und kleine Thrombozyten sind bei einem Jungen verdächtig für ein Wiskott-Aldrich-Syndrom [1].…”

Section: Stellenwert Der Immunologischen Basisdiagnostikunclassified

Diagnostik primärer Immundefekte

Bernuth

Schwarz

Renner

et al. 2011

Monatsschr Kinderheilkd

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Leitthema Der Beitrag von Baumann u. Niehues[2] vermittelt, wann ein angeborener Immundefekt wahrscheinlich ist. Im vorliegenden Beitrag wird ein abgestuftes Vorgehen zur Diagnostik bei Verdacht auf Immundefekt vorgestellt: Die Basisdiagnostik mit Differenzialblutbild und Immunglobulinspiegeln soll die meisten lebensbedrohlichen und häufige immunologische Erkrankungen erkennen. Erweiterte Diagnostik richtet sich am Infektionsspektrum, an Zeichen einer gestörten Immunregulation, an syndromalen Manifestationen und den Ergebnissen der Basisdiagnostik aus. Sie schließt Lücken derselben und grenzt die molekulare Ursache des Immundefekts auf einen Teilbereich des Immunsystems ein. Die exakte Beschreibung des klinischen und immunologischen Phänotyps ist Voraussetzung für eine gezielte und ökonomische molekulargenetische Dia gnostik.

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“…2 500 bekannten Salmonella -Serovaren [12] oder Ausdruck einer kongenitalen Abwehrschw ä che sein k ö nnen. So k ö nnen persistierende Infektionen mit den wenig lebensbedrohlichen Rotaviren Ausdruck eines schweren kombinierten Immundefekts sein [14] . Andererseits kommt es fernzuhalten.…”

Section: Schlussfolgerungen Und Empfehlungenunclassified

Reptilien-assoziierte Salmonelleninfektionen bei Säuglingen und Kleinkindern in Deutschland

Böhme

Fruth²,

Rabsch³

2009

Klin Padiatr

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Salmonellosis is an important disease in childhood. Increasing infections caused by meat and raw egg consumption starts in the second year of life. The transmission from reptiles to infants is an alternative route. Reptile-associated salmonellosis is becoming more significant for pediatricians and microbiologists due to the increasing numbers of household exotic pets. Investigations of routes of infections in connection with the local health authorities including microbiological, serological and molecular biological tests is possible in case of atypical salmonellosis. During recent years (2006-2008) an increasing number of salmonellosis cases caused by reptiles. Most of the 26 patients were infants of less than one year of age. Also Salmonella strains of subspecies II, IIIa, IIIb and IV play an important role. The US Centers for Disease Control and Prevention (CDC) has published recommendations which includes washing hands with soap and water after handling reptiles or the cages and keeping reptiles out of food preparation areas. The CDC has also adviced that children less than five years should not have reptiles as pets.

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Severe Combined Immunodeficiency Signalized by Eosinophilia and Lymphopenia in Rotavirus Infected Infants

Abstract: In infants with rotavirus infection, a full blood count should be performed: Eosinophilia and/or lymphopenia raise a high suspicion of SCID.

Cited by 8 publications

References 9 publications

Delayed Onset of (Severe) Combined Immunodeficiency (S)CID (T-B+NK+): Complete IL-7 Receptor Deficiency in a 22 Months Old Girl

Delayed Onset of (Severe) Combined Immunodeficiency (S)CID (T-B+NK+): Complete IL-7 Receptor Deficiency in a 22 Months Old Girl

Diagnostik primärer Immundefekte

Reptilien-assoziierte Salmonelleninfektionen bei Säuglingen und Kleinkindern in Deutschland

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