Severe clinical forms of Mediterranean Spotted Fever: A case series from an endemic area in Bulgaria

Baymakova, Magdalena; Pekova, Liliya; Plochev, K.; Parousheva, P.

doi:10.1016/j.ijid.2016.11.369

International Journal of Infectious Diseases

2016

DOI: 10.1016/j.ijid.2016.11.369

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Severe clinical forms of Mediterranean Spotted Fever: A case series from an endemic area in Bulgaria

Magdalena Baymakova

Liliya Pekova

K. Plochev

et al.

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Cited by 2 publications

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“…MSF is endemic to the Mediterranean, Europe, Africa, western Asia, and India. The case-fatality rate is 3%–7% in hospitalized patients ( 3 , 4 ).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Fatal Case of Mediterranean Spotted Fever Associated with Septic Shock, Iran

Esmaeili¹,

Latifian²,

Khalili³

et al. 2022

Emerg. Infect. Dis.

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“…MSF is endemic to the Mediterranean, Europe, Africa, western Asia, and India. The case-fatality rate is 3%–7% in hospitalized patients ( 3 , 4 ).…”

mentioning

confidence: 99%

“…When severe, MSF can manifest as septic shock, and acute kidney injury might occur. Thrombocytopenia and elevated liver enzymes are frequent laboratory abnormalities ( 4 , 7 ).…”

mentioning

confidence: 99%

Fatal Case of Mediterranean Spotted Fever Associated with Septic Shock, Iran

Esmaeili¹,

Latifian²,

Khalili³

et al. 2022

Emerg. Infect. Dis.

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Possibility of Serological Verification of Siberian Tick Typhus With the Test System for Identification of Rickettsia Conorii Antibodies

Рудаков

Штрек

Блох

et al. 2019

RCLD

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The real epidemiological impact of Spotted Fever Group rickettsioses including Siberian tick-borne typhus (STT) in Russia is not sufficiently studied. One of the reasons is the actual absence of either certified domestic diagnostic kits or the evidence for using foreign test kits for laboratory verification of this group of tick-borne infections in medical practice. Objective of our study was to study the diagnostic accuracy of the ELISA test system based on Rickettsia conorii antigens for serological verification of STT. The ROC analysis was performed and operational characteristics (sensitivity, specificity, accuracy, likelihood ratio of positive and negative results) of the STT serological verification test to identify IgM to rickettsia at different times from the onset of the disease using a test system to detect antibodies to Rickettsia conorii were calculated based on the results of a survey of two groups of patients comparable by gender and age (34 patients with pathognomonic signs of STT and 76 clinically healthy people). It was found that the detection of IgM antibodies to rickettsia using the Rickettsia conorii IgM/IgG ELISA test system (Vircell) allows the disease to be verified 10-14 days after the onset of clinical symptoms in 72% (56-88%) of STT patients. We recommend the interpretation of results of the test system “Rickettsia conorii ELISA IgM/IgG” for serological verification of STT which differ from the manufacturer’s recommendations regarding verification of Mediterranean fever caused by R. conorii in the following way: the diagnosis of STT should be considered laboratory confirmed when the index of IgM antibodies (IAT) exceeds 8.0; if the IAT is less than 5.0 then a repeated examination of the patient after 10-14 days will be necessary; if the IAT is in the range of 5.0-8.0 then the sample should be re-examined and / or the patient should be examined after 10-14 days. The use of the test system “Rickettsia conorii ELISA IgM / IgG” is promising for laboratory diagnosis and seroepidemiological studies of Spotted Fever Group rickettsioses in Russia.

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Severe clinical forms of Mediterranean Spotted Fever: A case series from an endemic area in Bulgaria

Cited by 2 publications

References 0 publications

Fatal Case of Mediterranean Spotted Fever Associated with Septic Shock, Iran

Fatal Case of Mediterranean Spotted Fever Associated with Septic Shock, Iran

Possibility of Serological Verification of Siberian Tick Typhus With the Test System for Identification of Rickettsia Conorii Antibodies

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