Severe chest pain in a pediatric ulcerative colitis patient after 5-aminosalicylic acid therapy

Atay, Orhan; Radhakrishnan, Kadakkal; Arruda, Janine; Wyllie, Robert

doi:10.3748/wjg.14.4400

Cited by 19 publications

(15 citation statements)

References 6 publications

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“…), contrast agents, and poison ivy may evoke this syndrome, and leukotriene (LT) is thought to play an important role in the pathogenesis of this syndrome. 12 Atay et al 13 reported the case of a 12-year-old boy who developed coronary spastic angina induced by 5-ASA. Kounis et al 14 suggested that this was likely to be a characteristic case of Kounis syndrome type I.…”

Section: Discussionmentioning

confidence: 99%

5‐Aminosalicylate intolerance causing exacerbation in pediatric ulcerative colitis

Shimizu

Arai

Tang

et al. 2017

Pediatrics International

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Section: Discussionmentioning

confidence: 99%

5‐Aminosalicylate intolerance causing exacerbation in pediatric ulcerative colitis

Shimizu

Arai

Tang

et al. 2017

Pediatrics International

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“…Pericarditis in pediatric IBD patients is rarely reported. So far, we could only identify 12 cases, of which seven were medication induced and four cases showed pericarditis as an extra‐intestinal manifestation of IBD (one unknown case; Table ) .…”

Section: Discussionmentioning

confidence: 99%

Recurrent pericarditis as an extra‐intestinal manifestation of ulcerative colitis in a 14‐year‐old girl

Gils

Gijlswijk²,

Taminiau

et al. 2018

Clinical Case Reports

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“…1--- 4 We report a case of mesalamine-induced myocarditis in a patient with a recent diagnosis of Crohn's disease.…”

Section: Introductionmentioning

confidence: 99%

Mesalamine-induced myocarditis following diagnosis of Crohn's disease: A case report

Braga

Martins

Arantes

et al. 2013

Revista Portuguesa de Cardiologia (English Edition)

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Mesalamine is a common treatment for Crohn's disease, and can be rarely associated with myocarditis through a mechanism of drug hypersensitivity. We present the case of a 19-year-old male who developed chest pain two weeks after beginning mesalamine therapy. The electrocardiogram showed slight ST-segment elevation with upward concavity in the inferolateral leads; blood tests demonstrated elevated troponin I and the echocardiogram revealed moderately depressed left ventricular systolic function with global hypocontractility. Cardiac magnetic resonance imaging confirmed the diagnosis of myocarditis, revealing multiple areas of subepicardial fibrosis. The onset of symptoms after mesalamine, and improvement of chest pain, cardiac biomarkers and left ventricular systolic function after discontinuing the drug, suggest that our patient suffered from a rare drug-hypersensitivity reaction to mesalamine. © 2012 Sociedade Portuguesa de Cardiologia. Published by Elsevier España, S.L. All rights reserved. PALAVRAS-CHAVEMiocardite; Mesalamina; Ecocardiografia transtorácica; Ressonância magnética cardíaca Miocardite induzida pela mesalamina após o diagnóstico de doença de Crohn ---relato de um caso clínico Resumo A mesalamina é um tratamento comum para a doença de Crohn, associando-se de forma rara à miocardite aguda, através de uma reação de hipersensibilidade ao fármaco. Os autores apresentam o caso clínico de um jovem de 19 anos com aparecimento de dor torá-cica duas semanas após ter iniciado tratamento com mesalamina para a doença de Crohn. O eletrocardiograma mostrou um discreto supradesnivelamento do segmento ST, de concavidade ascendente, nas derivações infero-laterais; as análises revelaram elevação da troponina I e o ecocardiograma exibiu uma depressão moderada da função sistólica do ventrículo esquerdo, por hipocontractilidade global. A ressonância magnética cardíaca confirmou o diagnóstico de miocardite, evidenciando múltiplas áreas de fibrose subepicárdica. O início dos sintomas após o começo da mesalamina e a melhoria da dor torácica, biomarcadores cardíacos e função sistólica * Corresponding author. E-mail address: carlos.galvaobraga@gmail.com (C. Galvão Braga).0870-2551/$ -see front matter © 2012 Sociedade Portuguesa de Cardiologia. Published by Elsevier España, S.L. All rights reserved. http://dx.doi.org/10.1016/j.repc.2012.12.018 Document downloaded from http://http://www.elsevier.pt, day 14/02/2014. This copy is for personal use. Any transmission of this document by any media or format is strictly prohibited. 718C. Galvão Braga et al. ventricular esquerda após a suspensão do medicamento, sugerem que o nosso paciente teve uma reação rara de hipersensibilidade à mesalamina.

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Severe chest pain in a pediatric ulcerative colitis patient after 5-aminosalicylic acid therapy

Abstract: Atay O, Radhakrishnan K, Arruda J, Wyllie R. Severe chest pain in a pediatric ulcerative colitis patient after 5-aminosalicylic acid therapy.

Cited by 19 publications

References 6 publications

5‐Aminosalicylate intolerance causing exacerbation in pediatric ulcerative colitis

5‐Aminosalicylate intolerance causing exacerbation in pediatric ulcerative colitis

Recurrent pericarditis as an extra‐intestinal manifestation of ulcerative colitis in a 14‐year‐old girl

Mesalamine-induced myocarditis following diagnosis of Crohn's disease: A case report

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