Severe chemotherapy toxicity in a 10-year-old with T-acute lymphoblastic lymphoma harboring biallelic FANCM variants

Myelodysplastic syndrome and multiple solid tumours in an individual with compound heterozygous deleterious FANCM variants: A case report and review of the literature

“…All 12 cases reported to date of biallelic FANCM variants associated with malignancies are summarized in Table 1, including this case (number 12). [5][6][7][8][9] All cases harboured homozygous variants except Cases 6, 10 and 12, which were compound heterozygous. Seven individuals (58%) were females, and the median age of first malignancy diagnosis was 32 (28-51) years.…”