Severe Cardiovascular Side Effects of Olanzapine in an Elderly Patient: Case Report

Lee, Tien-Wen; Tsai, Shi-Jen; Hwang, Jen‐Ping

doi:10.2190/u99g-xdml-0grg-bye0

Cited by 28 publications

(18 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There was no recurrence on administration of aripiprazole. There are few reports of hypotension associated with olanzapine, 4 , 5 ) one in an elderly individual, and the other with intramuscular administration. The summary of product characteristics for olanzapine reports 5% subjects develop orthostatic hypotension as compared to 2% in placebo, 6 ) which is much less as compared to the rates observed with first generation antipsychotics.…”

Section: Discussionmentioning

confidence: 99%

Olanzapine-induced Orthostatic Hypotension

Jana

Praharaj

Roy

2015

Clin Psychopharmacol Neurosci

View full text Add to dashboard Cite

Olanzapine is an atypical antipsychotic which is efficacious in the treatment of schizophrenia. The adverse effect profile for olanzapine is benign except for higher rates of metabolic events. Orthostatic hypotension is less commonly reported with olanzapine as compared to first-generation and few atypical antipsychotics. We report a case where olanzapine, in a dose dependent fashion, caused transient postural hypotension.

show abstract

Section: Discussionmentioning

confidence: 99%

Olanzapine-induced Orthostatic Hypotension

Jana

Praharaj

Roy

2015

Clin Psychopharmacol Neurosci

View full text Add to dashboard Cite

show abstract

“…We suspect that hypotension and bradycardia in our patient were provoked by olanzapine use, namely by blockage of the α 2 -adrenergic receptors [15]. The latter might also increase the hypothermic effect by inhibiting peripheral responses to cooling of the body [9].…”

Section: Discussionmentioning

confidence: 77%

“…This is the twelfth reported patient with olanzapine-induced hypothermia and the youngest pediatric patient with olanzapine-induced hypothermia described in the literature (PubMed Search for olanzapine and hypothermia 13.09.2011) (see Table 1) [5][6][7][8][9][12][13][14][15][16]. According to the literature, the risk of hypothermia is highest following initiation of the drug or after an increase in dosage.…”

Section: Literature Reviewmentioning

confidence: 86%

Olanzapine-associated hypothermia in an adolescent anorexic girl

Docx¹,

Simons²,

Ramet³

et al. 2012

OJCD

View full text Add to dashboard Cite

This is a 12th case report on olanzapine induced hypothermia and based on the results of literature search, by far is the youngest case ever is reported. The hypothermia occurred during the refeeding phase, despite a weight gain since increasing the dosage from 5 mg to 7.5 mg olanzapine. Our recent literature search found 11 published cases of olanzapine treatment associated with hypothermia. Olanzapine acts on serotonin or dopamin receptors and has antagonistic properties on histaminergic, muscarinic and <i>α</i>-adrenergic receptors. Olanzapine mediates the hypothermic effect through antagonism at receptors other than dopamine

show abstract

“…Since olanzapine exerts also influences on cholinergic, adrenergic and histaminergic pathways, an involvement of these pathways cannot be excluded [36]. The therapy of the rare but dangerous hypothermia caused by olanzapine [37] cannot comprehend substances affecting the orexinergic system to elevate body temperature: this system is blocked by olanzapine. We can suppose that the body weight gain could be caused, at least in part, by a decrease in the thermogenic changes due to orexin A.…”

Section: Discussionmentioning

confidence: 99%

Neuroleptic Drugs Affect Sympathetic and Thermogenic Reactions to Orexin A

S¹

2014

J Psychiatry

View full text Add to dashboard Cite

This review of our literature describes the effects of many neuroleptic drugs on the sympathetic and hyperthermic reactions due to orexin A, a neuropeptide affecting body temperature and food intake by an increase in sympathetic activity. Haloperidol reduces, while clozapine and olanzapine block the hyperthermia induced by orexin A. Risperidone enhances the elevation of body temperature due to orexin A. Quetiapine delays these hyperthermic effects. The implications on human therapeutic strategies are discussed, including the involvement of orexinergic pathway in the induction of obesity, induced by these neuroleptic substances. We summarize our published data in a unique report so to emphasize the influences of these neuroleptic drugs on the control of body temperature, exerted by orexinergic system. This large vision could be also useful to address therapeutic choices.Patients with serious mental illness are at higher risk of developing metabolic abnormalities (e.g., weight gain, increased blood pressure, and glucose or lipid levels) in comparison to general population. Since the risk increases following initiation of narcoleptic therapy, it must assess carefully risks and benefits when choosing a particular antipsychotic drug.

show abstract

Severe Cardiovascular Side Effects of Olanzapine in an Elderly Patient: Case Report

Cited by 28 publications

References 8 publications

Olanzapine-induced Orthostatic Hypotension

Olanzapine-induced Orthostatic Hypotension

Olanzapine-associated hypothermia in an adolescent anorexic girl

Neuroleptic Drugs Affect Sympathetic and Thermogenic Reactions to Orexin A

Contact Info

Product

Resources

About