Severe calcinosis cutis in an infant

Puvabanditsin, Surasak; Garrow, Eugene; Titapiwatanakun, Ruetima; Getachew, Rahel; Patel, Jigneshkumar B.

doi:10.1007/s00247-004-1363-9

Cited by 25 publications

(18 citation statements)

References 6 publications

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“…Normal serum ve kalsiyum fosfor seviyeleri gözlenir. Daha çok inflame, dejenere, neoplastik dokuda oluşur 6 . Bu tip kalsinozis kutis dermal kollajende travma ve inflamasyon sonucu inflamasyonlu bölgeye kalsiyum tuzlarının çökmesi şeklinde görülür 1,7 .…”

Section: Discussionunclassified

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El Parmaklarına Lokalize İdyopatik Kalsinozis Kutis

Çalka¹,

Bilgili²,

Karadağ³

et al. 2013

Turkderm

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ÖzetKalsinozis kutis, çözünmeyen kalsiyum tuzlarının deride birikimi ile karakterize nadir bir hastalıktır. Etyolojisine göre metastatik, distrofik, idyopatik ve iyatrojenik olmak üzere dört tipi vardır. Kalsinozis kutisin patofizyolojisi bilinmemektedir. Distrofik kalsinozis kutis en sık görülen tip iken, idiyopatik tip çok nadir görülür. İdyopatik tip etyolojisinde herhangi bir neden bulunamayan ve ilaç kullanımıyla ilişkisi olmayan tiptir. Başlıca lokalize (sirkumskript) ve jeneralize (universalis) tipleri bulunmaktadır. Lokalize tip genellikle vulva, skrotum, penis ve memede yerleşmektedir. Kesin tanısı histopatolojik olarak deride kalsiyum birikiminin gösterilmesiyle ve klinik olarak diğer tiplerin dışlanmasıyla konulmaktadır. Etkili bir tedavisi bulunmamaktadır. Polikliniğimize başvuran 47 yaşındaki kadın olgunun ellerinde 30 yıldır var olan ağrısız, sarımsı beyaz renkte nodülleri mevcuttu. Olguya klinik ve histopatolojik bulgularla idiyopatik sirkumskript kalsinozis kutis tanısı konuldu. Olgumuz nadir görülen idyopatik sirkumskript kalsinozis kutisin farklı bir lokalizasyonda olması, lezyonlarının literatürde daha önce bildirilmeyen bir lokalizasyonda olması nedeniyle bildirilmektedir. (Türk derm 2013; 47: 117-9) Anah tar Ke li me ler: Kalsinozis kutis, idyopatik, sirkumskript kalsinozis kutis Sum maryCalcinosis cutis is an uncommon disorder characterized by deposition of insoluble calcium salts in the skin. Based on the etiology of the deposition, calcinosis cutis may be divided into four major groups, namely, metastatic, dystrophic, idiopathic, and iatrogenic. The pathophysiology of calcinosis cutis remains unclear. The dystrophic form is the most common whereas the idiopathic one is the rarest. Idiopathic calcinosis cutis occurs in the absence of any identifiable causes and it has no association with drug use. Idiopathic calcinosis cutis has two major types called localized (circumscript) and generalized (universalis). Localized type generally involves the vulva, scrotum, penis and the breast. A definitive diagnosis requires the histologic demonstration of the accumulation of calcium in the skin and exclusion of other clinic types. There is not an effective treatment for the disease. A 47-year-old woman presented to our outpatient clinic with painless, yellowish-white nodules on her hand enduring for 30 years. A diagnosis of idiopathic calcinosis cutis was made by clinical and histological findings. We present this case because, to our knowledge, the localization of the lesions in our case has not been previously reported in the literature. (Turkderm 2013; 47: 117-9

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Section: Discussionunclassified

“…Olgumuzda kalsinozis kutis için iyatrojenik bir neden tespit edilemedi. İdyopatik tip kalsinozis kutis ise normal dokuda meydana gelmekte olup normal serum kalsiyum ve fosfor seviyeleri gözlenir 6 . İdyopatik terimi doku kalsifikasyonuna sebep olacak altta yatan bir neden bulunmadığında kullanılır 9 .…”

Section: Discussionunclassified

El Parmaklarına Lokalize İdyopatik Kalsinozis Kutis

Çalka¹,

Bilgili²,

Karadağ³

et al. 2013

Turkderm

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“…It is due to a variety of etiologies and classically, it can be classified as metastatic, dystrophic and idiopathic types [3]. The pathogenesis of this condition is unknown and probably multifactorial.…”

Section: Discussionmentioning

confidence: 99%

Unusual Idiopathic Calcinosis Cutis Universalis in a Child

Alabaz

Mungan²,

Turğut

et al. 2009

Case Rep Dermatol

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Calcinosis cutis is an uncommon disorder characterized by the progressive deposition of crystals of calcium phosphate (hydroxyapatite) in the skin in various areas of the body. It is classified into four types according to etiology, namely as dystrophic if calcium and phosphorus levels are normal and tissue damage is present, as idiopathic if calcium and phosphorus levels are normal and no tissue damage is present, or as metastatic if there is hypercalcemia or hyperphosphatemia. Medical and surgical treatments are options to cure calcinosis cutis. Medical therapy is not very effective. Surgical excision has shown to be beneficial, as it can provide a symptomatic relief. However, since calcinosis cutis limits are not always well defined, a recurrence of the lesions may occur. We dealt with a very rare form of calcinosis cutis in a healthy 6-year-old girl. There was no evidence of connective tissue disorder or abnormal mineral metabolism. Hence, she was diagnosed as idiopathic calcinosis cutis and, although calcifications in idiopathic cutis are most commonly localized to one area, our patient unusually exhibited widespread calcific deposits. Although the existing lesions showed slow improvement, systemic pamidronate therapy was effective in preventing the occurrence of new lesions. Surgical excision proved to be an effective and successful treatment. This report aims to raise doctors’ awareness on the presentation, etiopathogenesis, and course of the relatively rare idiopathic calcinosis cutis.

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“…The lesions are cystic and multilocular with a capsule and prominent fibrous septae on gross pathology. Histopathology reveals calcium deposits in the dermis, with or without a surrounding giant cell reaction [7].…”

Section: Discussionmentioning

confidence: 99%