Severe Burn Injury Progression and Phasic Changes of Gene Expression in Mouse Model

Wu, Dan; Zhou, Ming; Li, Liang; Leng, Xigang; Zhang, Zheng; Wang, Ning; Sun, Yanwei

doi:10.1007/s10753-019-00984-5

Cited by 6 publications

(2 citation statements)

References 66 publications

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“…Severe burn trauma induces pro-inflammatory immune responses in peripheral blood and affected tissues, regardless of infection (2,3). This immune response can persist up to months and can lead to additional health problems, including systemic inflammatory response syndrome (SIRS), hypermetabolic state and damage to surrounding tissues and even distant organs (4)(5)(6)(7). Trauma instantly causes inflammation and produces damage associated molecular patterns (DAMPs) through necrotic and injured tissue, which stimulates the immune system to recruit acute phase immune cells (8,9).…”

Section: Introductionmentioning

confidence: 99%

Persistent Systemic Inflammation in Patients With Severe Burn Injury Is Accompanied by Influx of Immature Neutrophils and Shifts in T Cell Subsets and Cytokine Profiles

et al. 2021

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Severe burn injury causes local and systemic immune responses that can persist up to months, and can lead to systemic inflammatory response syndrome, organ damage and long-term sequalae such as hypertrophic scarring. To prevent these pathological conditions, a better understanding of the underlying mechanisms is essential. In this longitudinal study, we analyzed the temporal peripheral blood immune profile of 20 burn wound patients admitted to the intensive care by flow cytometry and secretome profiling, and compared this to data from 20 healthy subjects. The patient cohort showed signs of systemic inflammation and persistently high levels of pro-inflammatory soluble mediators, such as IL-6, IL-8, MCP-1, MIP-1β, and MIP-3α, were measured. Using both unsupervised and supervised flow cytometry techniques, we observed a continuous release of neutrophils and monocytes into the blood for at least 39 days. Increased numbers of immature neutrophils were present in peripheral blood in the first three weeks after injury (0.1–2.8 × 106/ml after burn vs. 5 × 103/ml in healthy controls). Total lymphocyte numbers did not increase, but numbers of effector T cells as well as regulatory T cells were increased from the second week onward. Within the CD4+ T cell population, elevated numbers of CCR4+CCR6- and CCR4+CCR6+ cells were found. Altogether, these data reveal that severe burn injury induced a persistent innate inflammatory response, including a release of immature neutrophils, and shifts in the T cell composition toward an overall more pro-inflammatory phenotype, thereby continuing systemic inflammation and increasing the risk of secondary complications.

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Section: Introductionmentioning

confidence: 99%

Persistent Systemic Inflammation in Patients With Severe Burn Injury Is Accompanied by Influx of Immature Neutrophils and Shifts in T Cell Subsets and Cytokine Profiles

et al. 2021

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“…In addition, processes that enhance metabolism and catabolism were expressed. 54 In a study comparing microarray data from the Glue Grant Trauma‐Related Database to 10 elderly patients ( n = 10) and a sex‐ and TBSA burned ‐matched adult control group ( n = 20), differential expression between the elderly and adult groups. A number of immune‐related pathways were downregulated, including those associated with antigen processing via MHC class I, ubiquitination, and proteasomal degradation.…”

Section: Genetic Analysis Of Burn Patientsmentioning

confidence: 99%

Systemic immune response of burns from the acute to chronic phase

Osuka,

Shigeno,

Matsuura

et al. 2024

Acute Medicine & Surgery

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Immune responses that occur following burn injury comprise a series of reactions that are activated in response to damaged autologous tissues, followed by removal of damaged tissues and foreign pathogens such as invading bacteria, and tissue repair. These immune responses are considered to be programmed in living organisms. Developments of modern medicine have led to the saving of burned patients who could not be cured previously; however, the programmed response is no longer able to keep up, and various problems have arisen. This paper describes the mechanism of immune response specific to burn injury and the emerging concept of persistent inflammation, immunosuppression, and catabolism syndrome.

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Burn-Induced Local and Systemic Immune Response: Systematic Review and Meta-Analysis of Animal Studies

Mulder

Koenen

Vlig

et al. 2022

Journal of Investigative Dermatology

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Severe Burn Injury Progression and Phasic Changes of Gene Expression in Mouse Model

Cited by 6 publications

References 66 publications

Persistent Systemic Inflammation in Patients With Severe Burn Injury Is Accompanied by Influx of Immature Neutrophils and Shifts in T Cell Subsets and Cytokine Profiles

Persistent Systemic Inflammation in Patients With Severe Burn Injury Is Accompanied by Influx of Immature Neutrophils and Shifts in T Cell Subsets and Cytokine Profiles

Systemic immune response of burns from the acute to chronic phase

Burn-Induced Local and Systemic Immune Response: Systematic Review and Meta-Analysis of Animal Studies

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