Severe bullous allergic contact dermatitis caused by glycidyl methacrylate and other acrylates

Vogel, Tatiana A.; Christoffers, Wietske Andrea; Engfeldt, Malin; Bruze, M.; Coenraads, Pieter‐Jan; Schuttelaar, Marie L A

doi:10.1111/cod.12247

Cited by 8 publications

(4 citation statements)

References 7 publications

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“…These have very broad application as glues, as coatings, and in various plastic materials . Both acrylates and methacrylates are well known for their sensitizing potential, and for causing – sometimes severe – allergic contact dermatitis in those exposed to the monomers, be it as consumers or patients, or, in particular, professionally. Occupational exposure, particularly in dental technicians, attracted attention quite early .…”

mentioning

confidence: 99%

Contact allergy to acrylates and methacrylates in consumers and nail artists – data of the Information Network of Departments of Dermatology, 2004–2013

Uter

Geier

2015

Contact Dermatitis

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mentioning

confidence: 99%

Contact allergy to acrylates and methacrylates in consumers and nail artists – data of the Information Network of Departments of Dermatology, 2004–2013

Uter

Geier

2015

Contact Dermatitis

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“…Only very few other case reports with positive patch test results (for example Shanmugam and Wilkinson 2012;Vogel et al 2014) and some clinical epidemiological studies in small cohorts (for example Aalto-Korte et al 2010;Christoffers et al 2013;Ramos et al 2014) have been published since the 1999 supplement (supplement "n-Butyl acrylate" 2001). These showed that the number of contact allergic reactions caused by n-butyl acrylate remains similar to that caused by ethyl acrylate.…”

Section: Effects In Humansmentioning

confidence: 99%

n ‐Butyl acrylate [MAK Value Documentation, 2017]

Hartwig

Arand²

2018

The MAK‐Collection for Occupational Health and Safety

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The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of 2 ml/m 3 for n‐butyl acrylate. The critical effect in a two‐year inhalation study with rats was reserve cell hyperplasia with loss of ciliated or olfactory cells at the lowest concentration of 15 ml/m 3 . The lower confidence limit of the benchmark dose for an extra risk of 5% increase of the critical effect incidence (BMDL 05 ) of about 3 ml/m 3 , which had been calculated in the previous evaluations, was confirmed. Since 2014, the Commission uses an empirical approach to set MAK values for substances with critical effects on the upper respiratory tract or the eyes. Based on this approach, the equivalent concentration at the workplace is 1.5 ml/m 3 . However, studies in humans to investigate the sensory irritation of n‐butyl acrylate are lacking. As the structurally related ethyl acrylate possesses a RD 50 value as well as subchronic and chronic NOAECs similar to those of n‐butyl acrylate, the NOAEC of 2.5 ml ethyl acrylate/m 3 for sensory irritation in volunteers was used as a read‐across. As the MAK value for ethyl acrylate has been set at 2 ml/m 3 , the MAK value of 2 ml/m 3 for n‐butyl acrylate could be confirmed. In analogy to ethyl acrylate, the assignment of n‐butyl acrylate to Peak Limitation Category I and the excursion factor of 2 were confirmed. The NOAECs for developmental toxicity in rats and mice are sufficiently high so that damage to the embryo or foetus is unlikely when the MAK value is observed. Thus, n‐butyl acrylate continues to be classified in Pregnancy Risk Group C. The substance is marginally clastogenic in vitro but not in vivo and was not carcinogenic in a 2‐year inhalation study in rats. There are only a few cases of contact sensitization in humans but there are positive results in local lymph node assays. Data on airway sensitization are still not available. n‐Butyl acrylate continues to be designated with “Sh”. Skin absorption was calculated to contribute significantly to the systemic toxicity and n‐butyl acrylate is designated with an “H”.

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“…This has been demonstrated, for example, via the gene expression of p53, p21 and bcl2 [ 1 ]. These allergens affect both patients and dental personnel (dentists, dental assistance personnel, and dental technicians) [ 19 , 20 , 21 , 22 , 23 , 24 ]. To make prosthodontic treatment safer for patients with proven incompatibility to these materials, researchers have invented commercially viable hypoallergenic denture base resins.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Analysis of the Mechanical Properties of Hypoallergenic Denture Base Resins

et al. 2022

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The development of hypoallergenic denture resins is key to the treatment of patients with allergies to polymethyl methacrylate (PMMA). In this study, the in vitro mechanical properties of hypoallergenic and PMMA denture base resins were compared. Ninety-six test specimens of hypoallergenic denture base resins (Polyan Plus®, Sinomer, TMS Acetal Dental, Erkocryl) and 72 test specimens of PMMA-based denture base resins (Paladon 65, PalaXpress, SR-Ivocap) were fabricated. The flexural strength, elastic modulus, compressive strength, macro- and microhardness, average roughness, water absorption, and water solubility of the resins were measured. None of the hypoallergenic denture resins matched all the mechanical properties of the PMMA resins. Polyan Plus® and TMS Acetal Dental were closest to matching the mechanical properties of the PMMA resins, and TMS Acetal Dental had some superior properties. Consequently, Polyan Plus® and TMS Acetal Dental hypoallergenic resins are recommended for further investigation as potential alternatives to PMMA resins for the fabrication of removable dentures.

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Severe bullous allergic contact dermatitis caused by glycidyl methacrylate and other acrylates

Cited by 8 publications

References 7 publications

Contact allergy to acrylates and methacrylates in consumers and nail artists – data of the Information Network of Departments of Dermatology, 2004–2013

Contact allergy to acrylates and methacrylates in consumers and nail artists – data of the Information Network of Departments of Dermatology, 2004–2013

n ‐Butyl acrylate [MAK Value Documentation, 2017]

In Vitro Analysis of the Mechanical Properties of Hypoallergenic Denture Base Resins

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