Severe autoimmune hemolytic anemia in Covid-19 infection

Hindilerden, Fehmi; Yonal-Hindilerden, Ipek; Akar, Emre; Yeşilbağ, Zuhal; Kart-Yasar, Kadriye

doi:10.4084/mjhid.2020.053

Cited by 40 publications

(36 citation statements)

References 12 publications

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“…None of the previous reports involving newborns born to SARS-CoV-2 positive mothers describe hemolytic anemia, but there are reports of autoimmune hemolytic anemia in adults with SARS-CoV-2 infection, presumably caused by the cytokine storm or through molecular mimicry. [14][15][16][17] Most of the reported cases of SARS-CoV-2 infection associated with hemolytic anemia had an underlying condition predisposing to hemolysis such as spherocytosis, G-6-PD deficiency, or malignancy 18 similar to our cases.…”

Section: Discussionsupporting

confidence: 78%

Case Series of Hemolysis in Neonate Born to Mothers with History of SARS-CoV-2 Infection During Pregnancy

Itriago¹,

Lingappan²,

Teruya³

et al. 2020

Preprint

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Hemolytic anemia has been associated with SARS-CoV-2 infection in adult and pediatric patients, we report a case series of preterm newborns with hemolytic anemia whose mothers had a history of SARS-CoV-2 infection. In two of the cases maternal infection occurred early in pregnancy and the newborns had a reactive SARS-CoV-2 antibody test. Hemolysis and coagulopathy improved with the use of washed blood products and prothrombin complex concentrate. Our cases highlight the need for increased awareness of a possible association between hemolysis and exposure to SARS-CoV-2 infection during intrauterine life.

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Section: Discussionsupporting

confidence: 78%

Case Series of Hemolysis in Neonate Born to Mothers with History of SARS-CoV-2 Infection During Pregnancy

Itriago¹,

Lingappan²,

Teruya³

et al. 2020

Preprint

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“…Comparison of patients who were cured (meeting standards of hospital discharge) and those who were not cured showed that anemia and other factors were not associated with healing of COVID-19 during following-up (Table 4). thalassemia, 18 autoimmune hemolytic anemia, 19 and megaloblastic anemia, 20 have been recently reported. However, little proportion of attention was paid on common anemia in COVID-19 patients.…”

Section: Differences In Covid-19 Patients With Various Disease Conditmentioning

confidence: 99%

“…Coronavirus disease 2019 (COVID- 19), which is caused by a newly discovered positive-sense singlestranded RNA virus that termed SARS-CoV-2, has become an extensive pandemic worldwide since it is rstly broken out in Wuhan, Hubei Province in December 2019. [1][2] As of July 26, 2020, there were approximately 15,785,000 COVID-19 con rmed cases that existed in 215 countries or regions around the world, and nearly half of them were distributed in America, Brazil and India.…”

Section: Introductionmentioning

confidence: 99%

Association of the Anemia and COVID-19 in Hospitalized Patients

Chen

Zhou

Fan

et al. 2020

Preprint

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Coronavirus disease 2019 (COVID-19) has become an extensive pandemic worldwide since it is firstly broken out in Wuhan in December 2019. As of July 26, 2020, this disease has resulted in more than 600,000 of death and the numbers remains increasing. Pneumonia is commonly developed in COVID-19 confirmed patients, and it weakens lung functions and decreases the oxygen levels of blood. As an oxygen carrier, hemoglobin transport oxygen from lung to other organs and meanwhile plays a vital role in maintaining the balance of blood oxygen. Therefore, we speculate that a decrease of hemoglobin, also known as anemia, would weaken the oxygen transport and aggravates the illness of COVID-19. Moreover, anemia is commonly observed in a large proportion of COVID-19 confirmed patients. Taken together, anemia might be associated with the COVID-19. The aim of this study was performed to evaluate the clinical characteristics of COVID-19 confirmed patients with anemia and to further investigate the relationship between anemia and COVID-19.

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“…For HCT% Mean ± SD in mild stages of the disease were significantly higher (P1 < 0.001) compared to sever stage (40.69 ± 5.22 vs 35.87 ± 8.71% respectively), and the median were (43 vs 36.5 respectively). There are several reported cases where autoimmune hemolytic anemia occurred during the worsening of symptoms of Covid-19 infection [34][35][36]. Reduced Hb level with the associated reduction of oxygen carrying capacity of the blood together with CT diagnosed lung parenchymal pathology explains the significant dyspnea associated with increased disease severity.…”

Section: Discussionmentioning

confidence: 99%