Severe atypical neuropathy associated with administration of hematopoietic colony-stimulating factors and vincristine.

Weintraub, Michael; Adde, Magdalena; Venzon, D.; Shad, Aziza; Horak, Ivan D.; Neely, John E.; Seibel, Nita L.; Gootenberg, Joseph E.; Arndt, Carola A.S.; Nieder, Michael L.; Magrath, Ian

doi:10.1200/jco.1996.14.3.935

Cited by 59 publications

(39 citation statements)

References 21 publications

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“…Of the 26 patients who did not receive CSFs, 1 (4%) developed SAN, and of the 28 patients who received CSFs, 11 (39%) developed SAN [5]. Our patient had a more severe form of toxicity than the case reported by Weintraub et al [5].…”

Section: Discussioncontrasting

confidence: 52%

“…Neuropathy due to CSF has not been described [4]. Weintraub et al [5] recently described SAN due to vincristine and CSFs. SAN was characterized by constant severe, sharp or burning pain confined to the feet, which develops acutely with minimal or no prodrome.…”

Section: Discussionmentioning

confidence: 99%

“…The upper limbs were completely spared. Nine of the 12 patients reported by Weintraub et al [5] had severe motor neuropathy, manifested by complete foot drop and muscle power grade 0 to 2/5. The clinical course of SAN can be variable and some show quick recovery in a few days, while in others the recovery may be slow and may take several months.…”

Section: Discussionmentioning

confidence: 99%

“…CSFs have been associated with numerous side effects but neuropathy has not been described [4]. Weintraub et al [5] observed a severe atypical neuropathy (SAN) distinct from classical vincristine-induced neuropathy. SAN is characterized by acute onset of excruciating foot pain, usually associated with marked motor weakness and, completely sparing the upper limbs.…”

Section: Introductionmentioning

confidence: 99%

“…SAN is characterized by acute onset of excruciating foot pain, usually associated with marked motor weakness and, completely sparing the upper limbs. In their randomized study where chemotherapy was administered with and without CSFs, Weintraub et al [5] strongly associated the use of CSFs with the risk of developing SAN. The lack of other reports on CSFs precipitating neurotoxicity is surprising, and could be due to the paucity of trials in which the use of CSFs is randomized and therefore the role of CSFs in neurotoxicity may not be apparent.…”

Section: Introductionmentioning

confidence: 99%

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Granulocyte Colony-Stimulating Factor Potentiated Severe Atypical Vincristine-Induced Neuropathy

Al-Bahar¹,

Pandita²,

Savani³

et al. 1998

Med Princ Pract

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We report a patient with acute lymphoblastic leukemia who developed severe atypical neuropathy (SAN), distinct from classical vincristine neuropathy, following the use of vincristine and granulocyte colony-stimulating factor (G-CSF). SAN was characterized by acute onset of severe pain, exquisite tenderness on even light touch and profound motor weakness involving predominantly the lower limbs. The upper limbs were spared. Imaging studies and cerebrospinal fluid examination were normal. Electrophysiological studies showed axonal sensorimotor neuropathy. Potentiation of vincristine-induced neuropathy by G-CSF should be considered when formulating protocols using both these agents, and concomitant use of both the agents should be avoided.

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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