Severe Atopic Eczema, Recurrent Pneumococcal Meningitis and Recurrent Eczema Herpeticum

Eczema herpeticum in atopic dermatitis

“…These vesicles potentially lead to erosions after 2-7 days. [57][58][59] The skin morphology is often accompanied by general symptoms such Staphylococcal Scalded Skin Syndrome a as fever, malaise, and headache along with lymphadenopathy. 60,61 Furthermore, the clinical picture can be exacerbated by bacterial superinfections, most notably with streptococci and staphylococci.…”

“…The clinical manifestation of EH is characterized by disseminated non‐grouped vesicular eruptions and pustules on erythematous lesions, preferentially affecting the head, neck, chest, and arm (Figure 1). These vesicles potentially lead to erosions after 2‐7 days 57‐59 . The skin morphology is often accompanied by general symptoms such as fever, malaise, and headache along with lymphadenopathy 60,61 .…”

Atopic eczema is associated with delayed maturation of the antibody response to Pneumococcal vaccine

“…When the history and clinical features of atopic eczema in childhood are atypical, for example, in terms of unusual severity or poor response to topical corticosteroids, underlying rare disorders of immunity, such as Omenn's, Wiskott–Aldrich, Job's and Netherton's syndromes should be considered in the differential diagnosis [1]. In addition to these well‐characterized associations between childhood eczema and T lymphocyte immunodeficiencies, we have previously described two children attending our regional paediatric eczema clinic with life‐threatening/fatal infections associated with defective humoral responses to carbohydrate antigens or low IgG2 subclass levels [2,3]. It is therefore our routine practice to rule out immunodeficiencies in children attending our clinic who have unusually severe or atypical atopic eczema.…”