Severe asthma and cystic fibrosis: Overlapping phenotypes?

Riolo, Giovanna; Rodrigues, Kelly M.; Dai, Cathy; Day, Andrew G.; Lougheed, M. Diane

doi:10.1080/24745332.2018.1491018

Cited by 2 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, CFTR mutations have probably been linked to asthma severity. Riolo et al compared the clinical characteristics, including features of CFTR-related disorders and the prevalence of CFTR mutations in individuals with severe asthma and non-severe asthma, concluding that features of CFTR-related disorders (rhinosinusitis, nasal polyposis, and bronchiectasis) were more prevalent in severe asthma than non-severe asthma, while 11% of severe asthma patients had CFTR mutations, suggesting a possible association between CFTR mutations and asthma severity [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

The Association between CFTR Gene Mutation Heterozygosity and Asthma Development: A Systematic Review

Koumpagioti

Moriki

Boutopoulou

et al. 2023

JCM

View full text Add to dashboard Cite

Asthma is caused by complex interactions between environmental and genetic factors. Various genes have been implicated as potential risk factors in the development of asthma; among them is cystic fibrosis transmembrane conductance regulator (CFTR) gene. The aim of this systematic review was to investigate the association of CFTR mutation heterozygosity with the development of asthma, by updating the existing data with recent studies’ findings. Therefore, a systematic review of the literature was conducted on Pubmed, ESBCO (Cinahl) and Scopus Databases up to December 2022. After the eligibility assessment, 17 studies were included in this review. Nine of them supported a lack of relationship between CFTR mutation heterozygosity and asthma susceptibility, and eight reported a positive association. Consequently, more extensive research is needed through high-quality studies to provide valid evidence and highlight the clinical benefits of identifying CFTR mutations in asthma patients, their impact on asthma severity, or treatment perspectives.

show abstract

Section: Discussionmentioning

confidence: 99%

The Association between CFTR Gene Mutation Heterozygosity and Asthma Development: A Systematic Review

Koumpagioti

Moriki

Boutopoulou

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

The Emerging Role of Ion Channels in the Pathophysiology and Treatments of Asthma

Zhu¹

2021

E3S Web Conf.

View full text Add to dashboard Cite

Asthma is one of the most common chronic respiratory diseases in the world. Although treatments and medications that can control the symptoms of asthma are available, no cure has been developed. Ion channels are transmembrane proteins that facilitate the diffusion of ions across membranes. In the airways, ion channels are involved in signalling between cells and regulation of intracellular ion concentration, which may lead to the activation of airway cells, immune cells, and neurons. This review mainly focuses on discoveries made so far in animal models and clinical trials regarding ion channels and asthma and gives some insight into developing treatments targeting ion channels.

show abstract

Severe asthma and cystic fibrosis: Overlapping phenotypes?

Cited by 2 publications

References 26 publications

The Association between CFTR Gene Mutation Heterozygosity and Asthma Development: A Systematic Review

The Association between CFTR Gene Mutation Heterozygosity and Asthma Development: A Systematic Review

The Emerging Role of Ion Channels in the Pathophysiology and Treatments of Asthma

Contact Info

Product

Resources

About