Severe Anaphylactic Reaction with Ferric Carboxy Maltose: A Case Report

Sharma, Neeraj; Thiek, Lalnunnem Jion; Jethani, Roma; Khan, Dina Aisha; Jamil, Marcus

doi:10.7860/jcdr/2018/35875.11494

Cited by 1 publication

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“…Although extremely rare, serious anaphylactic reaction following FCM infusion is possible as is reported by Sharma et al . [ 30 ] in a patient who received FCM for moderate anaemia post suction and evacuation for incomplete abortion. The patient was managed symptomatically, recovered fully, and was discharged well.…”

Section: Discussionmentioning

confidence: 99%

Ferric carboxymaltose: A game changer in the management of iron deficiency anaemia in pregnancy

Sharma,

Kharkongor,

Sundaram

et al. 2024

Journal of Family Medicine and Primary Care

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Anaemia is a well-known global health concern in the South Asian countries, and it is estimated that India has the utmost prevalence of anaemia and maternal deaths due to iron deficiency anaemia. This study aims to assess the efficacy and safety of intravenous ferric carboxymaltose (FCM) in antenatal women with anaemia in the second and third trimesters of pregnancy. Methods: A single-arm prospective cohort (before–after) study among 60 antenatal women with moderate to severe anaemia in the second and third trimesters was conducted from December 2020 to December 2022, and the eligible women were given 1000 mg of intravenous FCM injection. Efficacy was assessed by rate of improvement in haemoglobin and ferritin at 2 weeks post infusion. Safety analysis was done by assessing adverse drug reactions and foetal heart monitoring during the infusion. Results: A total 60 antenatal women with a median gestational age of 32.5 weeks at presentation received 1000 mg of intravenous FCM. There was a rise in mean haemoglobin from 8.05 gm% pre-infusion to 10.93 gm% 2 weeks post infusion, showing a mean rise of 2.88 gm%. Similar improvement was noted in mean serum ferritin levels from 25.92 pre-infusion to 253.96 post FCM infusion. There were no reports of drug-related major adverse effects in the mother or the foetus. Conclusions: FCM is found to be safe and effective treatment with rapid replenishment of haemoglobin and ferritin levels in a single dose, which makes it suitable and compels consideration as the first choice for treatment of iron-deficiency anaemia.

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Section: Discussionmentioning

confidence: 99%