Severe Anaphylactic Reaction to Cisatracurium in a Child

Management of suspected immediate perioperative allergic reactions: an international overview and consensus recommendations

“…40 Only a few case reports have been published. 85,86 The diagnosis remained unproven 87,88 or speculative 89,90 in the majority of cases, as younger children can rarely cooperate with all aspects of allergy testing. As in adults, management of perioperative anaphylaxis in children is guided by the clinical presentation (Tables 4 and 5).…”

Randomised controlled trial comparing cisatracurium and vecuronium infusions in a paediatric intensive care unit

“…Adverse effects other than prolonged recovery from NMB for vecuronium were not observed. Prolonged weakness in adults [26] and anaphylaxis in adults [27,28] and children [29,30] have been reported with cisatracurium. Direct immunogenicity and acrylate-mediated immune activation has been suggested as a mechanism for cisatracurium-related anaphylaxis [15], and the incidence of anaphylactoid reaction has been estimated to be in the order of 1:10,000 [31].…”

Cost‐effectiveness of granulocyte colony‐stimulating factor prophylaxis in chemotherapy‐induced febrile neutropenia among breast cancer and Non‐Hodgkin's lymphoma patients under Taiwan's national health insurance system

“…However, the sensitivity for using diagnosis code to identify a neutropenia event in the outpatient setting could be low . Second, we were unable to include variables not routinely collected in the claims database, such as disease stage or severity, tumour type, bone marrow involvement and laboratory data . However, we have conducted two pilot studies using medical records in one cancer center to examine potential covariates of neutropenic events in the Taiwanese breast cancer patients and NHL patients .…”