Severe anaemia and multiple ecchymoses in a postpartum female due to acquired haemophilia A

Palangasinghe, D R; Gamage, V. N. U.; Bodinayake, Champica K; Mohotti, M. G. M.

doi:10.4038/gmj.v22i1.7965

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2022

2023

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“…The pattern of bleeding is distinct from congenital hemophilia as it occurs as spontaneous, unexpected attacks in the form of severe large ecchymosis or soft-tissue hematomas, as well as sometimes muscle, vaginal, gastrointestinal, or urogenital bleeding, in contrast to hemarthrosis in congenital hemophilia [12].…”

Section: Discussionmentioning

confidence: 99%

Acquired Postpartum Hemophilia A Presentation of Severe Hematuria: A Case Report

Abdelghany

2023

SEE J Immunol

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BACKGROUND: Acquired hemophilia A (AHA) is a rare, severe bleeding disorder caused by the development of autoantibodies against FVIII that may be idiopathic or secondary to medical conditions. Postpartum AHA can occur as early as 1–4 months after delivery or as late as 1-year postpartum. CASE REPORT: A 20-year-old female presented with vaginal bleeding 20 days after delivery, then ecchymotic patches developed 2 months later, followed by hematuria 2 months after that. Laboratory investigation revealed isolated, prolonged partial thromboplastin time that was not corrected by mixing 50:50 with fresh normal plasma. FVIII activity was markedly deficient, with a high titer of immediate-acting FVIII inhibitor antibodies. CONCLUSION: The case was diagnosed as postpartum AHA with a good response to the combined steroids and cyclophosphamide treatment.

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Section: Discussionmentioning

confidence: 99%