Severe allergic reaction: An unusual complication of barium enema

Javors, Bruce R.; Applbaum, Yaakov; Gerard, Perry

doi:10.1007/bf01887868

Cited by 23 publications

(4 citation statements)

References 12 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fisher (1993,1996) also published articles in which he suggested that the parabens are remarkably safe, effective preservatives and argued that no difficulty with sensitization or allergic contact dermatitis is being encountered from the presence of parabens in cosmetics which are in contact with the thin, delicate skin of the eyelids, a common site of allergic contact dermatitis from many other contactants. Javors et al (1984) and Schwartz et al (1984) reported hypersensitivity reactions to parabens after barium enema examinations. Fine and Dingman (1988) reported hypersensitivity dennatitis following suction-assisted lipectomy as a complication of paraben preservatives in the local anesthetic.…”

Section: Multiple Parabensmentioning

confidence: 99%

Final Amended Report on the Safety Assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in Cosmetic Products

2008

Int J Toxicol

160

View full text Add to dashboard Cite

Coal Tar is a semisolid by-product obtained in the destructive distillation of bituminous coal, which functions in cosmetic products as a cosmetic biocide and denaturant--antidandruff agent is also listed as a function, but this is considered an over-the-counter (OTC) drug use. Coal Tar is a nearly black, viscous liquid, heavier than water, with a naphthalene-like odor and a sharp burning taste, produced in cooking ovens as a by-product in the manufacture of coke. Crude Coal Tar is composed of 48% hydrocarbons, 42% carbon, and 10% water. In 2002, Coal Tar was reported to the Food and Drug Administration (FDA) to be used in four formulations, all of which appear to be OTC drug products. Coal Tar is monographed by the FDA as Category I (safe and effective) OTC drug ingredient for use in the treatment of dandruff, seborrhoea, and psoriasis. Coal Tar is absorbed through the skin of animals and humans and is systemically distributed. In short-term studies, mice fed a diet containing Coal Tar found it unpalatable, but no adverse effects were reported other than weight loss; rats injected with Coal Tar experienced malaise in one study and decreased water intake and increased liver weights in another; rabbits injected with Coal Tar residue experienced eating avoidance, respiratory difficulty, sneezing, and weight loss. In a subchronic neurotoxicity study using mice, a mixture of phenols, cresols, and xylenols at concentrations approximately equal to those expected in Coal Tar extracts produced regionally selective effects, with a rank order of corpus striatum > cerebellum > cerebral cortex. Coal Tar applied to the backs of guinea pigs increases epidermal thickness. Painting female rabbits with tar decreases the absolute and relative weights of the ovaries and decreased the number of interstitial cells in the ovary. Four therapeutic Coal Tar preparations used in the treatment of psoriasis were mutagenic in the Ames assay. Urine and blood from patients treated with Coal Tar were genotoxic in bacterial assays. Coal Tar was genotoxic in a mammalian genotoxicity assay and induced DNA adducts in various tissue types. Chronic exposure of mice to Coal Tar significantly decreased survival and liver neoplasms were seen in a significant dose-related trend; in other studies using mice lung tumors and perianal skin cancers were found. Coal Tar was comedogenic in three small clinical studies. Folliculitis is associated with the prolonged use of some tars. Several published reports describe cases of contact sensitivity to Coal Tar. Polycyclic aromatic hydrocarbons, which make up Coal Tar, are photosensitizers and cause phototoxicity by an oxygen-dependent mechanism. A retrospective study of the reproductive toxicity of Coal Tar in humans compared exposed women to controls and found little difference in spontaneous abortion and congenital disorders. Cancer epidemiology studies of patients who have received Coal Tar therapy of one form or other have failed to link treatment with an increase in the risk of cancer. Although the Cosmetic In...

show abstract

Section: Multiple Parabensmentioning

confidence: 99%

Final Amended Report on the Safety Assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in Cosmetic Products

2008

Int J Toxicol

160

View full text Add to dashboard Cite

show abstract

“…The most frequently reported area of barium complications is gastrointestinal barium angiography, with reports of barium infiltrating the mucosa of the venous plexus and causing a state of shock. (3) In the field of neurosurgery, there have also been case reports of shunt dysfunction caused by barium in pediatric shunts. In some cases, barium sulfate in the shunt catheter calcified over time, causing it to tear.…”

Section: Discussionmentioning

confidence: 99%

Repeated shunt dysfunction due to Barium allergy that was difficult to differentiate from shunt infection

Kikuchi,

Yokoya,

Oka

et al. 2023

J. Med. Invest.

View full text Add to dashboard Cite

We encountered a case of repeated shunt dysfunction caused by barium allergy. The patient was a 60-year-old male who underwent ventricular peritoneal shunting for hydrocephalus following subarachnoid hemorrhage due to a ruptured aneurysm ; however, it malfunctioned many times. A patch test performed after the third reconstruction was positive for barium. To the best of our knowledge, this is the first case report of shunt malfunction due to barium allergy. The patch test is useful in cases of suspected allergy-related dysfunction. We recommend the introduction of barium into antigen testing using the patch test.

show abstract

“…In the literature, there are many examples of latex sensitization and allergy after barium enema. 1,12, 15,16,19,21,25,30,33 It is believed that absorption of water soluble proteins of latex products by rectal mucosa during barium enema triggers sensitization and allergic reactions. 13 Powdered latex gloves and latex balloons on enema tips are frequently the main products associated with latex sensitization.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for latex sensitization in young children with myelomeningocele

Majed

Nejat²,

Khashab

et al. 2009

PED

View full text Add to dashboard Cite

Object Patients with myelomeningoceles (MMCs) are at increased risk of latex allergy and sensitization. Number of surgeries and history of atopy are known risk factors. The object of this study was to evaluate the role of diagnostic procedures and nonsurgical treatments in latex sensitization in young patients with MMC. Methods Seventy-three children with MMC were included in the study. For each child a questionnaire was administered and serum determination of IgE was performed, and 62 children underwent skin prick tests (SPTs), 60 of which had reliable results. Multivariate logistic regression modeling was performed, using latex sensitization as the dependent variable. Results The mean age of the 73 patients was 3.8 years. The SPT results were positive in 30.6%, whereas results of testing for latex-specific IgE were positive in only 8.2%. In univariate analysis, history of untethering, barium enema, and number of clean intermittent catheterizations (CICs) per day were significantly associated with positive results on the SPT. Although the number of surgical procedures was significantly higher in patients who had shunts, no significant relationship between the presence of a shunt and latex sensitization was seen. Conclusions The young age of the patients in this study may account for the low prevalence of latex sensitization that was found. In young patients with MMC, the numbers of CICs per day, a history of untethering, circumcision, and a barium enema performed without latex-free equipment could be risk factors for latex sensitization. The use of latex-free gloves in all procedures performed in these cases, nonlatex polyvinyl chloride catheters in CIC, and ordinary nonballoon tips in barium enemas could decrease the risk of sensitization.

show abstract

Severe allergic reaction: An unusual complication of barium enema

Cited by 23 publications

References 12 publications

Final Amended Report on the Safety Assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in Cosmetic Products

Final Amended Report on the Safety Assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in Cosmetic Products

Repeated shunt dysfunction due to Barium allergy that was difficult to differentiate from shunt infection

Risk factors for latex sensitization in young children with myelomeningocele

Contact Info

Product

Resources

About