Severe adverse cutaneous reaction to insulin due to cresol sensitivity

Rajpar, S. F.; Foulds, I. S.; Abdullah, A.; Maheshwari, Monika

doi:10.1111/j.0105-1873.2006.0866g.x

Cited by 33 publications

(22 citation statements)

References 8 publications

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“…Type I HS reactions to m-cresol have been reported with insulin [20,24]. To our knowledge, only one case of m-cresol sensitivity associated with rhGH has been reported.…”

Section: Discussionmentioning

confidence: 90%

Allergic and non-allergic skin reactions associated with growth hormone therapy: elucidation of causative agents

Mehta

Oza

Potashner

et al. 2017

Journal of Pediatric Endocrinology and Metabolism

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Background: Allergic and non-allergic skin reactions to recombinant human growth hormone (rhGH) are uncommon and infrequently reported. However, physicians should be aware of these potential side effects to determine whether the reactions constitute true allergies and how to proceed with growth hormone therapy. To review allergic and non-allergic skin reactions caused by rhGH and subsequent diagnostic workup and management options. Case presentation: We report the case of a 12-year-old healthy male presenting with idiopathic short stature. He developed an itchy skin rash over the chest and abdomen, 15 min after administration of the first dose of rhGH, leading us to review allergic and non-allergic skin reactions to rhGH. In our patient, an immediate skin reaction after administration of rhGH prompted a concern about a type I hypersensitivity reaction (HS) and the discontinuation of rhGH. However, after a dermatologic evaluation and observed administration of rhGH without subsequent rash, the initial eruption was likely an exacerbation of his underlying atopic dermatitis and a type I HS was felt to be unlikely. The rhGH was resumed and he has been on

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“…Type I HS reactions to m-cresol have been reported with insulin [20,24]. To our knowledge, only one case of m-cresol sensitivity associated with rhGH has been reported.…”

Section: Discussionmentioning

confidence: 90%

Allergic and non-allergic skin reactions associated with growth hormone therapy: elucidation of causative agents

Mehta

Oza

Potashner

et al. 2017

Journal of Pediatric Endocrinology and Metabolism

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“…Another novel stimulus on Trial 1 was the odor of m-cresol (3-methylfenol), the aromatic organic compound commercially used as solvent (preservative and stabilizer) of the insulin. Human diabetic patients report detecting the smell of m-cresol in their insulin [21]. The novel odor was present in the animal-housing room for the first time on Trial 1 and presumably detectable by mice whether getting insulin or saline injections.…”

Section: Discussionmentioning

confidence: 99%

Inconsistencies in the hypophagic action of intracerebroventricular insulin in mice

Allister

Pacheco-López

Woods

et al. 2015

Physiology & Behavior

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Insulin inhibits eating after its intracerebroventricular (ICV) administration in multiple species and under a variety of conditions. Nevertheless, the results across reports are inconsistent in that ICV insulin does not always reduce food intake. The reasons for this variability are largely unknown. Using mice as a model, we performed several crossover trials with insulin vs. vehicle when infused into the third cerebral ventricle (i3vt) to test the hypothesis that recent experience with the i3vt procedure contributes to the variability in the effect of ICV insulin on food intake. Using a cross-over design with two days between injections, we found that insulin (0.4 µU/mouse) significantly reduced food intake relative to vehicle in mice that received vehicle on the first and insulin on the second trial, whereas this effect was absent in mice that received insulin on the first and vehicle on the second trial. Higher doses (i3vt 4.0 and 40.0 µU/mouse) had no effect on food intake in this paradigm. When injections were spaced 7 days apart, insulin reduced food intake with no crossover effect. Mice that did not reduce food intake in response to higher doses of i3vt insulin did so in response to i3vt infusion of the melanocortin receptor agonist melanotan-II (MT-II), indicating that the function of the hypothalamic melanocortin system, which mediates the effect of insulin on eating, was not impaired by whatever interfered with the insulin effect, and that this interference occurred upstream of the melanocortin receptors. Overall, our findings suggest that associative effects based on previous experience with the experimental situation can compromise the eating inhibition elicited by i3vt administered insulin.

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“…İnsüline erken tip reaksiyon gelişen hastaya ilk yaklaşım; insülin tedavisini kesmek, semptomatik tedavi, alerji hekimi ile konsülte etmek ve insülin preparatını değiştirmek olmalıdır (17).…”

Section: -Erken Ti̇p Reaksi̇yonlarunclassified

Insulin allergy and the approach to a patient with insulin allergy

Börekçi¹

2016

Journal of Contemporary Medicine

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With the production of recombinant human insulin preparation, insulin allergy incidence has declined steadily. However, in some cases still it can lead to serious lifethreatening condition. Evaluation requires close collaboration with endocrinology and allergy experts. Our purpose in writing this article is to describe the allergic reactions to insulin with the current knowledge and to review the approach and treatment of patients with insulin allergy.

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Severe adverse cutaneous reaction to insulin due to cresol sensitivity

Cited by 33 publications

References 8 publications

Allergic and non-allergic skin reactions associated with growth hormone therapy: elucidation of causative agents

Allergic and non-allergic skin reactions associated with growth hormone therapy: elucidation of causative agents

Inconsistencies in the hypophagic action of intracerebroventricular insulin in mice

Insulin allergy and the approach to a patient with insulin allergy

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