Severe adult atopic dermatitis successfully treated with concurrent Unseiin and standard treatment

Abstract

Case:A 64 year-old woman suffering from atopic dermatitis refractory to standard treatment presented for treatment of severe skin eruptions on the whole body. Outcome: On her first visit, white blood cell count including eosinophils (3310/μL), serum lactate dehydrogenase (LDH; 460 IU/L), serum immunoglobulin E (19 694 IU/mL), and thymus and activation-regulated chemokine (TARC; 58 250 pg/mL) were elevated. Oral treatment with fexofenadine hydrochloride and topical steroids were started, but the eruptions and itching did not significantly improve. On day 18, concurrent treatment with Unseiin 7.5 g/day was started. On day 81, remission of skin eruption, and normal TARC (396 pg/mL), eosinophils (200/μL), and LDH (187 IU/L) were confirmed. Conclusion: Concurrent treatment with Unseiin and standard treatment may provide an effective treatment option for patients with atopic dermatitis refractory to standard treatment.