Severe Acute Respiratory Syndrome: Relationship between Radiologic and Clinical Parameters

Ooi, Clara G. C.; Khong, Pek Lan; Lam, Bing; Ho, James Chung Man; Yiu, Wai; Wong, Wai-Man; Wang, Teresa; Ho, Pak Leung; Wong, Puisan; Chan, Raymond H.; Lam, Wah Kit; Lai, Kar Neng; Tsang, K. T.

doi:10.1148/radiol.2292030736

Cited by 28 publications

(36 citation statements)

References 15 publications

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“…The characterstic HRCT features upon presentation were ground-glass opacities, sometimes with consolidation, and were associated with interlobular and intralobular septal thickenings. It has also been shown that radiographic and HRCT appearances were correlated to clinical and laboratory parameters [41,42]. [60,61].…”

Section: (B) Early Outcomes Of Sarsmentioning

confidence: 97%

Severe Acute Respiratory Syndrome (SARS): A Brief Review With Exploration of the Outcomes, Prognostic Factors and Sequelae

Chan¹,

2005

CRMR

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Severe Acute Respiratory Syndromes (SARS) is a novel infectious disease with significant morbidity and mortality. While heated debates and vigorous scientific investigations are still ongoing over the treatment, prevention and infection control of this deadly disease, substantial data has been accumulated concerning the outcomes and prognostic factors. Postmortem findings of the deceased have revealed diffuse alveolar damage, together with evidence of fibrosis and organization. A number of predicting indicators such as advanced age, presence of co-morbidities, extensive radiological involvement, high coronaviral load and elevated serum lactate dehydrogenase have been identified to be independent predictors for adverse clinical outcomes such as admission to intensive care unit, mechanical ventilation, and death. A number of recovered SARS patients experienced exertional breathlessness, malaise, asthenia during the early recovery phase, while restriction and isolated reduction in diffusion capacity were the commonest lung function abnormalities identified during the subsequent follow-up visits. Radiological abnormalities including residual groundglass appearance and fibrosis were still detectable in these patients from their high-resolution computed tomography after recovery. Some recovered SARS patients were found to be suffering from psychological problems and avascular necrosis of the large joints.

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Section: (B) Early Outcomes Of Sarsmentioning

confidence: 97%

Severe Acute Respiratory Syndrome (SARS): A Brief Review With Exploration of the Outcomes, Prognostic Factors and Sequelae

Chan¹,

2005

CRMR

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“…Radiographical, haematological, biochemical and microbiological evaluation A chest radiograph, complete blood counts, alanine transaminase (ALT) and renal function tests were performed daily [13]. Chest radiographs were scored according to the per cent of lung involvement in each lung (05normal, 1510%, 2520%, 105100% involvement).…”

Section: Patient Recruitment and Study Designmentioning

confidence: 99%

“…A radiographic progress was regarded as improved, unchanged or deteriorated if the radiographical score (within 5%) on day 3 was ,, equal to, or . that derived on day 1, respectively [13]. Symptoms, travel and contact history were prospectively obtained by infection control nurses with a standardised questionnaire.…”

Section: Patient Recruitment and Study Designmentioning

confidence: 99%

A prediction rule for clinical diagnosis of severe acute respiratory syndrome

Ho¹,

Chau²,

Yip³

et al. 2005

Eur Respir J

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A prospective study was undertaken to identify clinical, radiographical, haematological and biochemical profiles of severe acute respiratory syndrome (SARS) patients.A prediction rule, which demarcates low from high risk patients for SARS in an outbreak situation was developed. A total of 295 patients with unexplained respiratory illnesses, admitted to Queen Mary Hospital, Hong Kong SAR, China, in March to July 2003, were evaluated for clinical, radiological, haematological and alanine transaminase (ALT) data daily for 3 days after hospitalisation.In total, 44 cases were subsequently confirmed to have SARS by RT-PCR (68.2%) and serology (100%). The scoring system of attributing 11, 10, 3, 3 and 3 points to the presence of independent risk factors, namely: epidemiological link, radiographical deterioration, myalgia, lymphopenia and elevated ALT respectively, generated high and low-risk (total score 11-30 and 0-10, respectively) groups for SARS. The sensitivity and specificity of this prediction rule in positively identifying a SARS patient were 97.7 and 81.3%, respectively. The positive and negative predictive values were 47.8 and 99.5%, respectively.The prediction rule appears to be helpful in assessing suspected patients with severe acute respiratory syndrome at the bedside, and should be further validated in other severe acute respiratory syndrome cohorts.

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“…have abnormal chest radiographs, all of which show airspace consolidation that initially tends to be peripheral and lower zone in distribution [29][30][31]. Whilst most patients have abnormal chest radiograph on presentation, the patterns are usually no cavitation, hilar lymphadenopathy or pleural effusion at presentation [32].…”

Section: Bedside and Clinical Diagnosis Of Severe Acute Respiratory Smentioning

confidence: 99%

“…Whilst most patients have abnormal chest radiograph on presentation, the patterns are usually no cavitation, hilar lymphadenopathy or pleural effusion at presentation [32]. Generally, radiographical opacities peak 8-10 days after the onset of illness when bilateral disease is usually the case, and radiographic severity tends to correlate with clinical and laboratory parameters, such as oxygen saturation and liver transaminases [15,30,31]. Pneumomediastinum and pneumothoraces, often spontaneous but also occur with assisted ventilation, could complicate extensive disease ( fig.…”

Section: Bedside and Clinical Diagnosis Of Severe Acute Respiratory Smentioning

confidence: 99%

Diagnosis and pharmacotherapy of severe acute respiratory syndrome: what have we learnt?

Tsang¹

2004

European Respiratory Journal

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Severe Acute Respiratory Syndrome: Relationship between Radiologic and Clinical Parameters

Abstract: Severity of lung abnormalities quantified on chest radiographs correlates with clinical and laboratory parameters.

Cited by 28 publications

References 15 publications

Severe Acute Respiratory Syndrome (SARS): A Brief Review With Exploration of the Outcomes, Prognostic Factors and Sequelae

Severe Acute Respiratory Syndrome (SARS): A Brief Review With Exploration of the Outcomes, Prognostic Factors and Sequelae

A prediction rule for clinical diagnosis of severe acute respiratory syndrome

Diagnosis and pharmacotherapy of severe acute respiratory syndrome: what have we learnt?

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