Severe acute respiratory syndrome coronavirus 2 seroprevalence among personnel in the healthcare facilities of Croatia, 2020

Vilibić-Čavlek, Tatjana; Stevanović, Vladimir; Tabain, Irena; Betica-Radić, Ljiljana; Sabadi, Dario; Perić, Ljiljana; Bogdanić, Maja; Vilibić, Maja; Kolarić, Branko; Kudumija, Boris; Petrović, Goranka; Mrzljak, Anna; Karabuva, Svjetlana; Hrstić, Irena; Capak, Krunoslav; Kučinar, Jasmina; Savić, Vladimir; Barbić, Ljubo

doi:10.1590/0037-8682-0458-2020

Cited by 13 publications

(17 citation statements)

References 8 publications

(8 reference statements)

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“…Estimates of seroprevalence amongst HCWs have however varied widely. Within Europe, estimates of seroprevalence rates for HCWs range widely; studies in Germany,[ 15 ] Greece,[ 16 ] Croatia,[ 17 ] and Austria[ 18 ] have demonstrated low rates (1%, 1.07%, 2% and 3.2%, respectively) while Belgium (6.4%),[ 19 ] Spain (9.3%),[ 6 ] and the UK, in some studies,[ 4 , 20 ] have had higher rates. The interpretation of differences in seroprevalence rates between countries is however complicated by the fact that rates have been shown to vary widely between studies in the same country.…”

Section: Discussionmentioning

confidence: 99%

Cross-sectional prevalence of SARS-CoV-2 antibodies in healthcare workers in paediatric facilities in eight countries

Green

Johnson

Falup‐Pecurariu

et al. 2021

Journal of Hospital Infection

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Section: Discussionmentioning

confidence: 99%

Cross-sectional prevalence of SARS-CoV-2 antibodies in healthcare workers in paediatric facilities in eight countries

Green

Johnson

Falup‐Pecurariu

et al. 2021

Journal of Hospital Infection

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“…The antibody titre was defined as the reciprocal value of the highest serum dilution that showed 100% neutralization in at least half of the infected wells. A titre of ≥ 8 was considered positive and protective and titre of 2-4 was considered positive, but unprotective (16).…”

Section: Methodsmentioning

confidence: 99%

Seroprevalence of SARS-CoV-2 infection among children in Children’s Hospital Zagreb during the initial and second wave of COVID-19 pandemic in Croatia

Krleža¹,

Topić

Stevanović³

et al. 2021

Biochem. med. (Online)

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Introduction:The study aimed to investigate the prevalence and titres of anti-SARS-CoV-2 antibodies in children treated at the Children's Hospital Zagreb in the first and the second wave of the COVID-19 pandemic. Statistical significance of difference at two time points was done to determine how restrictive epidemiological measures and exposure of children to COVID-19 infection affect this prevalence in different age groups. Materials and methods: At the first time point (13th to 29th May 2020), 240 samples and in second time point (24th October to 23rd November 2020), 308 serum samples were tested for anti-SARS-CoV-2 antibodies by enzyme-linked immunosorbent assay (ELISA) and electrochemiluminescence immunoassay (ECLIA). Confirmation of results and titre determination was done using virus micro-neutralization test. Subjects were divided according to gender, age and epidemiological history. Results: Seroprevalence of anti-SARS-CoV-2 antibodies differs significantly in two time points (P = 0.010). In first time point 2.9% of seropositive children were determined and in second time point 8.4%. Statistically significant difference (P = 0.007) of seroprevalence between two time points was found only in a group of children aged 11-19 years. At the first time point, all seropositive children were asymptomatic with titre < 8. At the second time point, 69.2% seropositive children were asymptomatic with titre ≥ 8. Conclusions: The prevalence of anti-SARS-CoV-2 antibodies was significantly lower at the first time point than at the second time point. Values of virus micro-neutralization test showed that low titre in asymptomatic children was not protective at the first time point but in second time point all seropositive children had protective titre of anti-SARS-CoV-2 antibodies.

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“…In April 2020, SARS-CoV-2 antibodies were detected in 1.27% of industry workers in two counties at the Croatian littoral [ 33 ]. A similar seroprevalence rate of 1.5% was found among personnel of the healthcare facilities from counties with a high incidence of COVID-19 tested from April 25 to May 24, when the COVID-19 epidemic curve was approaching the end of the first wave in Croatia [ 32 ]. Additionally, SARS-CoV-2 IgG antibodies were detected in 2.9% of children and 2.5% adults from the Zagreb area [ 129 ].…”

Section: Respiratory Virusesmentioning

confidence: 63%

“…A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a respiratory virus that emerged in February 2020 and spread rapidly throughout the country. Acute infections as well as seropositivity have been confirmed in humans and pet animals [ 32 , 33 , 34 ]. The rabies virus (RABV) still presents a major veterinary and public health threat.…”

Section: Zoonotic Viruses In Croatiamentioning

confidence: 99%

Emerging and Neglected Viruses of Zoonotic Importance in Croatia

et al. 2021

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Several arboviruses have emerged in Croatia in recent years. Tick-borne encephalitis is endemic in continental counties; however, new natural micro-foci have been detected. Two autochthonous dengue cases were reported in 2010. West Nile virus emerged in 2012, followed by emergence of Usutu virus in 2013. Although high seroprevalence rates of Toscana virus have been detected among residents of Croatian littoral, the virus remains neglected, with only a few clinical cases of neuroinvasive infections reported. Lymphocytic choriomeningitis virus is a neglected neuroinvasive rodent-borne virus. So far, there are no reports on human clinical cases; however, the seroprevalence studies indicate the virus presence in the Croatian mainland. Puumala and Dobrava hantaviruses are widely distributing rodent-borne viruses with sporadic and epidemic occurrence. Hepatitis E virus is an emerging food-borne virus in Croatia. After the emergence in 2012, cases were regularly recorded. Seropositivity varies greatly by region and population group. Rotaviruses represent a significant healthcare burden since rotavirus vaccination is not included in the Croatian national immunization program. Additionally, rotaviruses are widely distributed in the Croatian ecosystem. A novel coronavirus, SARS-CoV-2, emerged in February 2020 and spread rapidly throughout the country. This review focuses on emerging and neglected viruses of zoonotic importance detected in Croatia.

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Severe acute respiratory syndrome coronavirus 2 seroprevalence among personnel in the healthcare facilities of Croatia, 2020

Cited by 13 publications

References 8 publications

Cross-sectional prevalence of SARS-CoV-2 antibodies in healthcare workers in paediatric facilities in eight countries

Cross-sectional prevalence of SARS-CoV-2 antibodies in healthcare workers in paediatric facilities in eight countries

Seroprevalence of SARS-CoV-2 infection among children in Children’s Hospital Zagreb during the initial and second wave of COVID-19 pandemic in Croatia

Emerging and Neglected Viruses of Zoonotic Importance in Croatia

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