Severe acute respiratory syndrome coronavirus 2 detected in placentas of 2 coronavirus disease 2019–positive asymptomatic pregnant women—case report

Sánchez, J.; Gracia, Paulino Vigil-De; Guerrero, Erika N.; Gaitán, Melissa; Fu, Cindy; Chen-Germán, María; Villalobos, Rodrigo; Coronado, Luis; Martínez, Alexander A.; Araúz, Dimelza; Sáenz, Lisseth; Chavarria, Oris; Góndola, Jessica; Moreno, Ambar; González, Claudia; Vega, Shantal; Campana, Sara; Chinkee, Jorge Ng; López‐Vergès, Sandra; Solís, Mairim Alexandra

doi:10.1016/j.xagr.2020.100001

Cited by 5 publications

(8 citation statements)

References 21 publications

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“…This may be supported by demonstrating the restriction of SARS-CoV-2 replication by IFITM proteins through its amphipathic helix domain [ 66 ]⁠. Whole-genome sequencing (WGS) of placentas that tested positive for SARS-CoV-2 found no remarkable virus adaptation for placental infection [ 64 , 67 ]⁠.…”

Section: Resultsmentioning

confidence: 99%

Coronavirus disease 2019 and the placenta: A literature review

Gesaka¹,

Obimbo²,

Wanyoro³

2022

Placenta

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Section: Resultsmentioning

confidence: 99%

Coronavirus disease 2019 and the placenta: A literature review

Gesaka¹,

Obimbo²,

Wanyoro³

2022

Placenta

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“…Nonetheless, placentas from SARS-CoV-2 infected women have been reported to have signs of inflammation villitis, and vascular malperfusion that may be direct or indirect consequences of the diseases. 24 Although SARS-CoV-2 has been detected in the placental tissues by electron microscopy 25 and RT-PCR, 26,27 vertical transmission of SARS-CoV-2 appears to be rare 28,29 and the vast majority of neonatal infections appear to occur by horizontal transmission in the neonatal period with little impact on child health.…”

Section: Discussionmentioning

confidence: 99%

Association between SARS-CoV-2 Infection and Adverse Perinatal Outcomes in a Large Health Maintenance Organization

Getahun

Peltier

Lurvey³

et al. 2022

Am J Perinatol

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Objective This study aimed to examine whether severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection during pregnancy is associated with increased odds of perinatal complications and viral transmission to the infant. Study Design A retrospective cohort study of women who delivered at Kaiser Permanente Southern California hospitals (April 6, 2020–February 28, 2021) was performed using data extracted from electronic health records (EHRs). During this time polymerize chain reaction (PCR)-based tests for SARS-CoV-2 was universally offered to all pregnant women at labor and delivery admission, as well as earlier in the pregnancy, if they were displaying symptoms consistent with SARS-CoV-2 infection or a possible exposure to the virus. Adjusted odds ratio (aOR) was used to estimate the strength of associations between positive test results and adverse perinatal outcomes. Results Of 35,123 women with a singleton pregnancy, 2,203 (6%) tested positive for SARS-CoV-2 infection with 596 (27%) testing positive during the first or second trimester and 1,607 (73%) during the third trimester. Women testing positive were younger than those who tested negative (29.7 [5.4] vs. 31.1 [5.3] years; mean [standard deviation (SD)]; p < .001). The SARS-CoV-2 infection tended to increase the odds of an abnormal fetal heart rate pattern (aOR: 1.10; 95% confidence interval [CI]: 1.00, 1.21; p = 0.058), spontaneous preterm birth (aOR: 1.28; 95% CI: 1.03, 1.58; p = 0.024), congenital anomalies (aOR: 1.69; 95% CI: 1.15, 2.50; p = 0.008), and maternal intensive care unit admission at delivery (aOR: 7.44; 95% CI: 4.06, 13.62; p < 0.001) but not preeclampsia/eclampsia (aOR: 1.14; 95% CI: 0.98, 1.33; p = 0.080). Eighteen (0.8%) neonates of mothers who tested positive also had a positive SARS-CoV-2 test after 24 hours of birth, but all were asymptomatic during the neonatal period. Conclusion These findings suggest that prenatal SARS-CoV-2 infection increases the odds of some adverse perinatal outcomes. The likelihood of vertical transmission from the mother to the fetus was low (0.3%), suggesting that pregnancy complications resulting from SARS-CoV-2 infection pose more risk to the baby than transplacental viral transmission. Key Points

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“…Además, diversos estudios de casos informan de la presencia de ARN del SARS-CoV-2 9,24,[26][27][28][29][30][31][32][33][34][35] , de proteína nucleocápside SARS 24,[34][35][36][37][38] o de partículas virales 37,39 . De manera relevante, se ha reportado la presencia de SARS-CoV-2 principalmente en el sincitiotrofoblasto 24,25,27,31,34,35,38,40 , mientras que un par de estudios han evidenciado la presencia del virus en el endotelio fetal 36,41 . Llama la atención que la detección del virus en el endotelio fetoplacentario ha sido en pacientes asintomáticas para COVID-19, una característica que deberá ser corroborada con más estudios.…”

Section: Estudios Sobre Sars-cov-2 En La Placentaunclassified