Severe Acute Respiratory Syndrome Coronavirus 2 Spreads to Lymph Nodes and Strongly Expands CD4+ Effector Memory RA Cells in a Patient With Mild Coronavirus Disease 2019

Roldán-Santiago, Ernesto; Benito-Berlinches, Amparo; Martínez-García, Laura; Quereda, Carmen; Rodrı́guez-Martı́n, Eulalia; Pérez-Elías, Pilar; López-Pintor, José María; Walo-Delgado, Paulette Esperanza; Moreno-Zamora, Ana; Fernández-Velasco, José Ignacio; García‐Abellás, Patricia; Ballester-González, Rubén; Villar, Luisa María; Pérez-Elías, María Jesús

doi:10.1093/cid/ciaa1422

Cited by 4 publications

(8 citation statements)

References 10 publications

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“…However, we have found no reports regarding the onset of tonsillitis, such as tonsillar redness and pus coating, in COVID-19 patients, except for a single case report of co-infection with both EBV and COVID-19 [15] . In addition, if both fine-needle aspiration cytology and a subsequent LAMP examination had been conducted on the specimens from the swollen cervical lymph nodes in this case similarly as Roldán-Santiago et al [17] reported, then the cause-effect relationship between the IM and SARS-CoV-2 might have been confirmed.…”

Section: Discussionsupporting

confidence: 58%

“…In IM caused by an initial EBV infection, massive proliferation of T lymphocytes activated by EBV-infected B cells is considered to cause the enlargement of the tonsils and cervical lymph nodes. Roldán-Santiago et al [17] reported that SARS-CoV-2 was detected in the cervical lymph nodes by fine-needle aspiration cytology in three COVID-19 cases showing lymphadenopathy. SARS-CoV-2 has been reported to infect various types of cells expressing ACE2 via the viral S protein, since ACE2 is ubiquitously expressed in almost all cells.…”

Section: Discussionmentioning

confidence: 99%

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Development of infectious mononucleosis as an unusual manifestation of COVID-19

et al. 2022

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It has generally been reported that patients with COVID-19 show a fever, cough, and/or respiratory failure as the most common clinical symptoms but some have unusual symptoms, such as anosmia, diarrhea, and throat pain. We herein report a 26-year-old woman with chief complaints of lymphadenopathy and a fever. First, she underwent a laboratory examination, which showed a high proportion of atypical lymphocytes (19%) and an increase in hepatic enzyme activities, and was then hospitalized with a diagnosis of infectious mononucleosis (IM). However, the blood examination did not show any increase in anti-Epstein-Barr virus VCM-IgM. Subsequently, she developed tonsillar hypertrophy with purulent plugs. An additional examination for infection of other pathogens revealed positivity only for SARS-CoV-2 in a loop-mediated isothermal amplification (LAMP) test. The patient was transferred to the COVID-19-specific isolation ward, and none of the ward staff, patients, or either of the two otolaryngologists who had directly examined this patient showed positive signs for SARS-CoV-2 in a LAMP test. Consequently, this case suggests that even if patients show clinical symptoms and signs of common diseases for otolaryngologists, such as IM, we should keep in mind the possibility of COVID-19 without arbitrarily assuming that IM is caused by Epstein-Barr virus.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Development of infectious mononucleosis as an unusual manifestation of COVID-19

et al. 2022

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“…Radiographic analysis has concluded that lymphadenopathies are characteristically absent in most SARS-COV-2 patients who were investigated using CT, which seems rare. 7 FNAC is the most preferable diagnostic tool to detect CLA. Our case was idiosyncratic as the patient was symptomatic with only fever, right sided neck pain and odynophagia and these findings were consistent with MIS-C.…”

Section: Discussionmentioning

confidence: 99%

“…2 CLA is one of the clinical features of MIS-C, that had only seen in 6% patients who were hospitalized for COVID-19. 7 Henceforth we will describe the first case of MIS-C post-COVID-19 infection with CLA in India was reported in a young adult.…”

Section: Introductionmentioning

confidence: 96%

Post Covid Multisystem Inflammatory Syndrome with Cervical Lymphadenopathy In A Young Adult

BlessySamu¹,

Abhijith²,

Ts³

et al. 2021

JYP

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Multisystem inflammatory syndrome-children is considered as a paediatric hyper inflammatory condition prompted by severe acute respiratory system coronavirus 2, which has multi-organ involvement. Among them cervical lymphadenopathy is an unusual presentation in multisystem inflammatory syndrome-children. A case study of 17 year old post coronavirus disease 2019 male patient, whose clinical presentation and elevated inflammatory markers on blood tests lead to the diagnosis of multisystem inflammatory syndrome-children is explained here. Evidence from computed tomography, ultrasonography and fine needle aspiration cytology revealed the rare presentation of multisystem inflammatory syndrome-children with cervical lymphadenopathy. Standard guidelines were followed in the treatment of the condition and the prognosis was closely monitored clinically, the available objective evidences manifested progressive response and outcome.

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“… 3 Also, there is still a concern of infected lymphoid cells left in the donated intestine as active replicating SARS‐CoV‐2 has been found in intestinal tract. 4 …”

mentioning

confidence: 99%

Small bowel transplantation from SARS‐CoV‐2 respiratory PCR positive donors: Is it safe?

Natori

Anjan

Simkins

et al. 2021

Transplant Infectious Dis

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We read with great interest the recently published article titled "The pandemic provides a pathway: What we know and what we need to know about COVID positive donors" by Eichenberger et al. 1 The coronavirus disease of 2019 (COVID-19) pandemic has significantly affected the solid organ transplant (SOT) community. Even though mortality has improved compared to the beginning of the pandemic, it still remains high. Hence, as organ transplantation continues globally, it is crucial to

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Severe Acute Respiratory Syndrome Coronavirus 2 Spreads to Lymph Nodes and Strongly Expands CD4+ Effector Memory RA Cells in a Patient With Mild Coronavirus Disease 2019

Cited by 4 publications

References 10 publications

Development of infectious mononucleosis as an unusual manifestation of COVID-19

Development of infectious mononucleosis as an unusual manifestation of COVID-19

Post Covid Multisystem Inflammatory Syndrome with Cervical Lymphadenopathy In A Young Adult

Small bowel transplantation from SARS‐CoV‐2 respiratory PCR positive donors: Is it safe?

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