Severe Acute Pancreatitis as an Index Clinical Manifestation of Parathyroid Adenoma

Sunkara, Tagore; Caughey, Megan E.; Rawla, Prashanth; Yarlagadda, Krishna Sowjanya; Gaduputi, Vinaya

doi:10.7759/cureus.2445

Cited by 9 publications

(8 citation statements)

References 9 publications

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“…However, studies have demonstrated a similar frequency of pancreatitis among patients with primary hyperparathyroidism and controls [67,68]. Recently, studies have demonstrated genetic variants in patients with hyperparathyroidism who presented pancreatitis, mainly associated with mutations in the CFTR gene and the SPINK1 gene [67,[69][70][71].…”

Section: Hypercalcemiamentioning

confidence: 98%

Systematic Review of Most Common Causes of Acute Pancreatitis

Roberto¹,

Zilio²,

Lucas³

et al. 2019

Preprint

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Introduction: Cholelithiasis and consumption of alcohol are the most frequent causes of acute pancreatitis (AP), accounting for about 30 to 40% of the cases, respectively. The frequency of acute biliary pancreatitis is high in a certain population in Brazil. Objective: To estimate the global frequencies of acute biliary pancreatitis (ABP), acute alcoholic pancreatitis (AAP) and the cases considered as acute idiopathic pancreatitis (AIP) in studies published from October 2006 to December 31, 2018. Methods: A systematic review of observational studies was performed from October 2006 to December 31, 2018. A meta-analysis by the random effects model was used to calculate the frequencies of global ABP, AIP and AAP and subgroups. Results: Forty-six studies representing 2,341,007 AP cases were included in 36 countries. The overall estimate for acute biliary pancreatitis (ABP) was 41.6% (95% CI 39.2-44.1), followed by acute alcoholic pancreatitis (AAP) with 20.5% (95% CI) 16.6- 24.6) and acute idiopathic pancreatitis (AIP) in 18.3% (95% CI 15.1-27.7). Conclusion: ABP is the most prevalent etiology of AP, being two times more frequent than second-placed pancreatitis. Latin America has a frequency for ABP much higher than the rest of the world. The importance of the etiologic diagnosis is the treatment of the cause for prevention of recurrence.

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Section: Hypercalcemiamentioning

confidence: 98%

Systematic Review of Most Common Causes of Acute Pancreatitis

Roberto¹,

Zilio²,

Lucas³

et al. 2019

Preprint

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“…No entanto, esse dado não é consensual. Outros artigos orientam sua dosagem somente se não houver associação clara com cálculos biliares ou alcoolismo 2,9 . Apesar da divergência, se for detectado valores de cálcio superiores à normalidade, secundários a secreção de PTH sugere-se o diagnóstico de HPP 7 .…”

Section: Relato De Casounclassified

Hiperparatireoidismo primário: relato de caso sobre uma apresentação rara de pancreatite aguda

Dias

Kuroda

Dib

et al. 2020

ACS

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Introdução: A pancreatite aguda (PA) é uma condição inflamatória comum nos centros médicos com uma incidência anual mundial de 4,9 - 73,4 casos por 100.000 habitantes e tem como principais causas o cálculo biliar (40-70%) e o etilismo (25-35%) seguidas de outras condições incomuns, entre elas a hipertrigliceridemia e a hipercalcemia. A PA devido a hipercalcemia, embora rara, pode representar dificuldade diagnóstica e, em muitos casos, ser diagnosticada tardiamente. Objetivo: Relatar um caso raro de pancreatite aguda causada por hipercalcemia. Relato de Caso: Paciente internado quatro vezes em três anos com queixa de dor abdominal. No momento inicial foi feito o diagnóstico de pancreatite alcoólica reforçado pelo histórico pessoal de etilismo crônico. Na última internação do paciente foram investigados os níveis séricos de cálcio total e paratormônio (PTH), com valores respectivos de 12,2 mmol/L e 178,8 pg/mL, sugerindo possível hiperparatireoidismo primário (HPP). Confirmou-se a hipótese com a cintilografia de paratireoide e o paciente foi submetido à paratireoidectomia esquerda e tireoidectomia parcial homolateral, apresentando melhora dos níveis séricos de PTH no pós-operatório, assim como do seu quadro de PA. Conclusão: A dosagem de cálcio sérico em pacientes com quadro de PA pode ser benéfica para o diagnóstico, instituiçãoprecoce de tratamento e controle de recidivas em pacientes com HPP.

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“…CT demonstrates gas in the presence of necrosis. If sterile, it is managed conservatively and only requires therapy in rare cases that obstructs a nearby viscus, for example, stomach, duodenum or bile duct [86,107,108].…”

Section: Local Complicationsmentioning

confidence: 99%

Review of Current Evidence in the etiopathogenesis, epidemiology, diagnosis and management of acute pancreatitis

Varley¹,

Rossi²,

Murray³

et al. 2019

Preprint

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Acute pancreatitis (AP) is an inflammatory condition of the pancreas and is one of the most common ailments of the gastrointestinal system that results in significant morbidity and mortality. The main etiologic causes of AP are alcohol consumption, gallstones, hypertriglyceridemia, and biliary stones. The clinical signs and symptoms, and diagnostic criteria of AP are well established in the literature and multiple studies. Multiple scoring systems have been used to predict the severity, prognosis, and mortality associated with AP. The present review of the literature brings to light the significant and recent contributions in the etiology, risk factors, epidemiology, diagnosis, complications, prognosis and newest modalities in treatment that could be beneficial in the management of AP.

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Severe Acute Pancreatitis as an Index Clinical Manifestation of Parathyroid Adenoma

Cited by 9 publications

References 9 publications

Systematic Review of Most Common Causes of Acute Pancreatitis

Systematic Review of Most Common Causes of Acute Pancreatitis

Hiperparatireoidismo primário: relato de caso sobre uma apresentação rara de pancreatite aguda

Review of Current Evidence in the etiopathogenesis, epidemiology, diagnosis and management of acute pancreatitis

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