Severe Acute Pancreatitis

Practice Guidelines in Acute Pancreatitis

“…It has been estimated that in the United States there are 210,000 admissions for acute pancreatitis each year (13). Most patients with acute pancreatitis experience abdominal I.…”

“…However, it is now clear some of the information included in the classification was subject to different interpretations, and that criteria of severity as defined by the Atlanta Symposium have not been used in a uniform fashion in recent publications (3,10,13,25,27,31,. In addition, there is new scientific information that should be included in a revised classification.…”

“…These and subsequent guidelines (2-7) have undergone periodic review (6,(8)(9)(10)(11)(12)(13) in accordance with advances that have been made in the diagnosis and treatment of acute pancreatitis. Guidelines for clinical practice are intended to apply to all health-care providers who take care of patients with acute pancreatitis and are intended to be flexible, and to suggest preferable (but not the only) approaches.…”

Role of IL-10 gene polymorphisms in the development of acute pancreatitis

“…The pathophysiology of this disease includes edema, hemorrhage, and necrosis (Gorelick and Thrower, 2009). Previous studies have reported that approximately 35% of acute pancreatitis patients develop severe complications, resulting in high mortality rates (Neoptolemos et al, 1998;Lankisch et al, 2003;Swaroop et al, 2004). Acute pancreatitis is a complex disease, and the accurate mechanisms underlying its development are not well understood.…”

The management of the patient with acute pancreatitis: from evidence to clinical practice

“…28 In some patients, the pain may be in the right upper quadrant or, rarely, confined to the left side. In patients with gallstone pancreatitis, the pain is well localized and the onset of pain is rapid, reaching maximum intensity in 10 to 20 min.…”