Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data
Jessie Torgersen,
Alyssa K. Mezochow,
Craig W. Newcomb
et al.
Abstract:ImportanceCurrent approaches to classify the hepatotoxic potential of medications are based on cumulative case reports of acute liver injury (ALI), which do not consider the size of the exposed population. There is little evidence from real-world data (data relating to patient health status and/or the delivery of health care routinely collected from sources outside of a research setting) on incidence rates of severe ALI after initiation of medications, accounting for duration of exposure.ObjectiveTo identify t… Show more
Lo Re V III, Haynes K, Goldberg D, et al. Validity of diagnostic codes to identify cases of severe acute liver injury in the US Food and Drug Administration's Mini-Sentinel Distributed Database.
Lo Re V III, Haynes K, Goldberg D, et al. Validity of diagnostic codes to identify cases of severe acute liver injury in the US Food and Drug Administration's Mini-Sentinel Distributed Database.
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