Severe Acute Corneal Hydrops in a Patient With Down Syndrome and Persistent Eye Rubbing

Özcan, Altan Atakan; Ersöz, Taner

doi:10.1007/s12009-007-0009-6

Cited by 16 publications

(8 citation statements)

References 4 publications

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“…Despite intensive clinical and laboratory investigation, its precise etiology is unknown 5,6. Keratoconus is mostly an isolated disorder, although several reports describe systemic association with Down syndrome, Leber’s congenital amaurosis, and connective tissue disorders such as Turner’s syndrome 7,8. Atopy and vernal keratoconjunctivitis (VKC) are often cited as being highly associated with keratoconus 9,10.…”

Section: Introductionmentioning

confidence: 99%

Keratoconus patients at Jordan University Hospital: a descriptive study

Ameerh

Refai²,

Bdour³

2012

OPTH

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PurposeTo study a sample of keratoconus patients, who were referred to Jordan University Hospital for possible penetrating keratoplasty (PKP), and provide basic epidemiological analysis.MethodA descriptive study; we reviewed the medical records of 308 keratoconus patients referred for possible PKP. The following parameters were collected and analyzed: sex predilection, age at presentation, best corrected visual acuity, severity, bilaterality of the disease, and its association with vernal catarrh.ResultsMales constituted 61.6% while females constituted 38.4% of the study group. The mean age at presentation for males and females was 19.1 and 19.9 years, respectively. The best corrected visual acuity on evaluation was ≤6/60 in 60.4% of males’ eyes and 57.9% of females’ eyes; >6/60 and <6/12 in 30% of males’ eyes and 28.5% of females’ eyes; and ≥6/12 in 9.6% of males’ eyes and 13.6% of females’ eyes. Regarding the severity, 72.3% of males’ eyes and 71.8% of females’ eyes had severe keratoconus; 17.3% of males’ and 28.2% of females’ eyes had moderate keratoconus; and 10.4% of males’ eyes had mild keratoconus, which was not recorded in females. 90.5% of male patients and 93.2% of female patients had bilateral disease and vernal catarrh was recorded in 33.7% of males and 35.6% of females.ConclusionKeratoconus was found to be more prevalent in Jordanian males referred for PKP than females, keeping in mind that this doesn’t reflect the real sex predilection in the general population. Males also presented at a younger age. We didn’t find any association between gender and bilaterality, nor association with vernal catarrh.

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Section: Introductionmentioning

confidence: 99%

Keratoconus patients at Jordan University Hospital: a descriptive study

Ameerh

Refai²,

Bdour³

2012

OPTH

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“…In 2002, Lucarelli et al reported another case of corneal ectasia associated with massage for dacryocystoceles [4]. Also eye rubbing has been implicated in the pathogenesis of keratoconus [5][6][7]. These facts lead us to suppose that excessive post-trabeculectomy massage may lead to corneal deformation and even breaks in Descemet membrane, causing stromal and epithelial edema.…”

Section: Discussionmentioning

confidence: 99%

Acute Keratoconus-Like Corneal Hydrops Secondary to Ocular Massage Following Trabeculectomy

Ke¹,

Chen²,

Lin³

2017

J Clin Exp Ophthalmol

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Purpose: To report a case of acute keratoconus-like corneal hydrops in a patient with long-term ocular massage following trabeculectomy. Methods:Case report and review of medical literature. Results:A rare complication of acute keratoconus-like corneal hydrops occurred in a patient following the use of ocular massage to maintain satisfactory aqueous humor filtration after trabeculectomy. The patient had a history of high myopia but denied previous ocular trauma, allergic disease and a family history of keratoconus. Slit-lamp examination demonstrated keratoconus-like corneal hydrops with formation of epithelial microcystic, and intrastromal cleft. He was diagnosed with acute corneal hydrops in the right eye and received intracameral gas (16% perfluoropropane) injection. On 5 months follow-up, the corneal edema was significantly improved. Conclusions:There may be a contributory relationship between the long-term post-trabeculectomy massage and the development of acute corneal hydrops. When prescribing therapeutic massage, patients should be followed up carefully to monitor for unexpected complications.

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“…The frequent occurrence of keratoconus has been attributed to a high incidence of eye rubbing in these two disorders, due to increased blepharitis in Down syndrome and an oculo-digital sign in Leber congenital amaurosis [1]. Eye rubbing has been implicated in the pathogenesis of keratoconus [7][8][9][10]. A study of eye rubbing prevalence found that it was reported in 80% of keratoconic subjects and in 58% of controls [6].…”

Section: Discussionmentioning

confidence: 99%

Acute Corneal Hydrops in Down Syndrome

Makino¹

2012

J Clin Case Rep

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We report a case of severe acute corneal hydrops in a 32-year-old woman with keratoconus associated with Down syndrome. The anterior segment of her right eye showed an extremely diffuse edematous ectasia of acute corneal hydrops. She was observed rubbing her right eye because of itchiness and discomfort in the eye. Complete resolution of the corneal edema and a central corneal scar was seen at the 6 th week of follow-up.

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Severe Acute Corneal Hydrops in a Patient With Down Syndrome and Persistent Eye Rubbing

Cited by 16 publications

References 4 publications

Keratoconus patients at Jordan University Hospital: a descriptive study

Keratoconus patients at Jordan University Hospital: a descriptive study

Acute Keratoconus-Like Corneal Hydrops Secondary to Ocular Massage Following Trabeculectomy

Acute Corneal Hydrops in Down Syndrome

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