Severe Acquired Immunodeficiency in Male Homosexuals, Manifested by Chronic Perianal Ulcerative Herpes Simplex Lesions

Siegal, Frederick P.; López, Carlos; Hammer, Glenn S.; Brown, Arthur E.; Kornfeld, Stephen J.; Gold, Jonathan W. M.; Hassett, Joseph M.; Hirschman, Shalom Z.; Cunningham‐Rundles, Charlotte; Adelsberg, Bernard R.; Parham, David M.; Siegal, Marta; Cunningham‐Rundles, Susanna; Armstrong, Donald

doi:10.1016/s0022-5347(17)52991-2

Cited by 95 publications

(115 citation statements)

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“…The virus infects and damages both CD4 [2] and antigen-processing eells [3]. The upshot of these effects is anergy to skin test antigens [4], low lymphocyte proiiferative responses to both mitogens and antigens, together with impaired production of cytokines [5], and poor control of viral [6] and bacterial pathogens such as Mycobacterium tuberculosis [7] and Streptococcus pneumoniae [8]. B cell responses are also deranged, resulting in high serum immunoglobulin levels [9] and abnormally low responses to some immunogens, including vaccines [10].…”

Section: Introductionmentioning

confidence: 99%

Immunological responses of Gambians in relation to clinical stage of HIV-2 disease

Whittle

Egboga

Todd

et al. 1993

Clinical and Experimental Immunology

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SUMMARYThis study describes a broad spectrum of cellular and antibody-mediated immune responses found in 28 asymptomatic and 37 symptomatic Gambian patients with HIV-2 infection. It shows that these responses vary according to the stage of infection as described by three clinical staging systems. The first system was a local one based on the signs used for the WHO Bangui clinical definition of AIDS, the second, suggested by WHO, was based on a performance scale, and the third was that used by the Centre for Disease Control. Asymptomatic patients had significantly lower mean CD4 counts, lymphoproliferative and interferon-gamma (IFN-y) responses and lower IgG and IgM antibody responses to keyhole limpet haemocyanin (KLH) than controls. These measurements and the size of the skin test reaction to purified protein derivative (PPD) or Candida antigen declined significantly according to the stage of infection. Mean values of the serological markers (82-microglobulin and neopterin and antibody titres to Epstein-Barr virus capsid antigen (EBVCA) rose significantly according to severity of disease. The Gambian or WHO clinical staging systems, which are easy and cheap to apply, may serve as an alternative to sophisticated and expensive immunological measurements when trying to stage disease and prediet prognosis.

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Section: Introductionmentioning

confidence: 99%

Immunological responses of Gambians in relation to clinical stage of HIV-2 disease

Whittle

Egboga

Todd

et al. 1993

Clinical and Experimental Immunology

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show abstract

“…Jaffe and McMahon-Pratt (1983) first indicated in their Epidemiological studies conducted in 1981 and 1982 that the major channel of transmission of AIDS were intimate sexual contact and contaminated blood. Gottlieb et al (1981); Masur et al (1981); Siegal et al (1981); Callazos et al (2010); van…”

Section: Portals Of Hiv Transmissionmentioning

confidence: 99%

Human Immunodeficiency Virus Transmission

Nanjul¹

2011

Global View of HIV Infection

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“…Los niveles de IgG sérica están elevados. Mediante pruebas de fijación de complemento es posible determinar títulos de anticuerpos elevados contra CMV, HSV y Adenovirus (59). Las determinaciones cuantitativas de los factores Clq, C3, C4, C5 y C9 del complemento, así como su funcionalidad valorada mediante la capacidad hemolítica total son normales [6).…”

Section: Manifestaciones Clinicasunclassified

“…591: finalmente, los resultados de las subpoblaciones de linfocitos T muestran: marcada disminución de los linfocitos T cooperadores (TH]; aumento del porcentaje de los linfocitos T supresores, y por consiguiente, una inversión de la relación cooperadores/supresores (6,59). Aunque la inversión de dicha relación no es específica del síndrome, constituye un hallazgo constante en los sujetos que presentan IGO (59). Existe también un aumento del porcentaje de células T que responden al antíguo T10, hallazgo también documentado en infecciones por EBV y CMV (59).…”

Section: Manifestaciones Clinicasunclassified

Síndrome de inmunodeficiencia adquirida

Yunis¹

1983

biomedica

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Severe Acquired Immunodeficiency in Male Homosexuals, Manifested by Chronic Perianal Ulcerative Herpes Simplex Lesions

Cited by 95 publications

References 0 publications

Immunological responses of Gambians in relation to clinical stage of HIV-2 disease

Immunological responses of Gambians in relation to clinical stage of HIV-2 disease

Human Immunodeficiency Virus Transmission

Síndrome de inmunodeficiencia adquirida

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