Severe 25-OH vitamin D deficiency as a reason for adverse pregnancy outcomes

Kısa, Burcu; Kansu-Celik, Hatice; Çandar, Tuba; Koç, Esin; Sert, Ümit Yasemin; Uzunlar, Özlem

doi:10.1080/14767058.2018.1554040

Cited by 6 publications

(7 citation statements)

References 26 publications

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“…Vitamin-D deficiency is a worldwide health problem that affects women's health and many adverse pregnancy outcomes. However, there is still doubt about the lack of randomized controlled trials to support the associated risk factors and vitamin-D levels during pregnancy [21]. Vitamin-D deficiency has been associated with several adverse health outcomes.…”

Section: Discussionmentioning

confidence: 99%

Association between different levels of maternal vitamin-D status during pregnancy and maternal outcomes

Alanazi

Aboushady

Kamel

2022

Clinical Nutrition ESPEN

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Section: Discussionmentioning

confidence: 99%

Association between different levels of maternal vitamin-D status during pregnancy and maternal outcomes

Alanazi

Aboushady

Kamel

2022

Clinical Nutrition ESPEN

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“…Some studies have suggested that mothers with vitamin D deficiency are at an increased risk of cesarean Sect. 12 – 17 , while others have found no link between serum levels of 25(OH) D and type of delivery 29 – 32 . This discrepancy may be due to various confounding factors that were not accounted for in most of these studies.…”

Section: Introductionmentioning

confidence: 92%

“…Several studies have examined the relationship between 25(OH)D concentrations and mode of delivery, but their findings have been inconsistent and inconclusive 12 – 17 , 29 – 32 . Some studies have suggested that mothers with vitamin D deficiency are at an increased risk of cesarean Sect.…”

Section: Introductionmentioning

confidence: 99%

Mode of delivery and maternal vitamin D deficiency: an optimized intelligent Bayesian network algorithm analysis of a stratified randomized controlled field trial

Amiri

Rostami

Sheidaei

et al. 2023

Sci Rep

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This study aimed to elucidate the algorithm of various influential factors relating to the association between 25-hydroxyvitamin D (25(OH)D) concentration at delivery and mode of delivery. The investigation constituted a secondary analysis using data collected as part of the Khuzestan Vitamin D Deficiency Screening Program in Pregnancy, which is a stratified randomized vitamin D supplementation-controlled trial comprising 1649 eligible pregnant women. The Bayesian Network (BN) method was utilized to determine the association algorithm between diverse influential factors associated with maternal vitamin D and mode of delivery. The optimized intelligent BN algorithm revealed that women presenting with moderate (35.67%; 95% CI: 33.36–37.96) and severe vitamin D deficiency (47.22%; 95% CI: 44.81–49.63) at delivery were more likely to undergo cesarean section than those presenting with normal concentrations of this nutritional hormone (18.62%; 95% CI: 16.74–20.5). The occurrence probabilities of preeclampsia in mothers with normal, moderate, and severe vitamin D deficiency at delivery were (1.5%; 95% CI: 0.92–2.09), (14.01%; 95% CI: 12.33–15.68), and (26.81%; 95% CI: 24.67–28.95), respectively. Additionally, mothers with moderate (11.81%; 95% CI: 10.25–13.36) and severe (27.86%; 95% CI: 25.69–30.02) vitamin D deficiency exhibited a higher probability of preterm delivery in comparison to those presenting with normal concentrations (1.12%; 95% CI: 0.62–1.63). This study demonstrated that the vitamin D status of pregnant women at delivery could directly affect the mode of delivery and indirectly through maternal complications, such as preeclampsia and preterm delivery, leading to a higher occurrence probability of cesarean section.

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“…Open access increased risk of gestational diabetes mellitus, which mediates an increased risk of macrosomia and the need for a caesarean section, as well as maternal osteomalacia, myopathy and neonatal vitamin D deficiency. [5][6][7] In terms of the effects of maternal vitamin D deficiency on the fetus and neonate, several studies and a metaanalysis have observed an increased risk of preterm birth when maternal serum 25(OH)D levels are lower than 50 nmol/L. [8][9][10][11] In addition, the risk of delivering smallfor-gestational age neonate was shown to be significantly increased in two meta-analyses if mothers were deficient in vitamin D during pregnancy.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Level of adherence to vitamin D supplementation guidelines in an antenatal centre in Birmingham, UK, and its effect on biochemical and obstetrical outcomes: a single-centre cross-sectional study

et al. 2021

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ObjectivesA third of pregnant women in the UK are vitamin D deficient, which may confer deleterious consequences, including an increased risk of pre-eclampsia, gestational diabetes mellitus and intrauterine growth restriction. This study aims to determine the proportion of women that met National Institute for Health and Care Excellence (NICE) standards for vitamin D supplementation in pregnancy and compare biochemical and obstetrical outcomes according to supplementation status.Design and settingThis is a single-centre cross-sectional study in an antenatal centre in Birmingham, UK. Participants received a questionnaire regarding their experiences with vitamin D supplementation during their pregnancy with their general practitioner. Serum 25-hydroxyvitamin D and bone profile results were obtained during the same appointment and obstetrical outcomes were collected retrospectively once participants had delivered.Results41.8% of participants (n=61) received written and/or verbal advice about supplementation, (NICE standards=100%). 72.6% (n=106) had one or more risk factors for vitamin D deficiency, of which 38.7% (n=41, NICE standards=100%) were asked about supplementation. Among those asked, 85.4% (n=41, NICE standards=100%) received the correct dosage. Compared with the supplementation group, the non-supplementation group had offspring that were 1.40 cm (95% CI 0.01 to 2.80, p=0.04) longer at birth; which was significant after adjusting for confounding factors. No significant differences in any biochemical parameters were observed between supplementation categories (p>0.05).ConclusionsAdherence to NICE standards was suboptimal. This may be attributed to insufficient training for general practitioners on the importance of supplementation, causing them to underestimate the consequences of gestational vitamin D deficiency. Recommendations include implementing a mandatory screening tool to identify ‘at-risk’ women and providing more clinician training to ensure that supplementation during pregnancy is standard of care.

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Severe 25-OH vitamin D deficiency as a reason for adverse pregnancy outcomes

Cited by 6 publications

References 26 publications

Association between different levels of maternal vitamin-D status during pregnancy and maternal outcomes

Association between different levels of maternal vitamin-D status during pregnancy and maternal outcomes

Mode of delivery and maternal vitamin D deficiency: an optimized intelligent Bayesian network algorithm analysis of a stratified randomized controlled field trial

Level of adherence to vitamin D supplementation guidelines in an antenatal centre in Birmingham, UK, and its effect on biochemical and obstetrical outcomes: a single-centre cross-sectional study

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