Several different cytogenetic clones arising during treatment of Philadelphia positive chronic myeloid leukemia with tyrosine kinase inhibitors lead to the progression into Philadelphia negative acute myeloid leukemia

Abstract

When the final article is assigned to volumes/issues of the Journal, the Article in Press version will be removed and the final version appear in the associated published volumes/issues of the Journal. The date the article was made available online first will be carried over. primenom TKI terapije TKI ne treba da isključi regularno testiranje kostne srži bolesnika sa CML citogenetskom analizom. Otkrivanje kariotipskih abnormalnosti sa lošom prognozom je od velikog značaja zbog mogućnosti razvoja sekundarnih malignitetamijelodisplastičnog sindroma i AML. Ključne reči: hronična mijeloidna leukemija, tirozin kinazni inhibitori, filadelfija hromozom, rezistencija na terapiju, abnormalnosti hromozoma 7.