Seven years survey of susceptibility to marbofloxacin of bovine pathogenic strains from eight European countries

A seven-year survey of susceptibility to marbofloxacin of pathogenic strains isolated from pets

“…All these results were comparable with those published for all fluoroquinolone used in veterinary medicine [1,8,10]. No difference in marbofloxacin susceptibility between 1989 and 2000 could be observed in classical urinary pathogenic strains (mainly E. coli), respiratory pathogenic strains (mainly Pasteurellaceae), dermatological pathogenic strains (mainly S. intermedius, S. aureus) or other pets' bacteria (P. aeruginosa).…”

“…No difference in marbofloxacin susceptibility between 1989 and 2000 could be observed in classical urinary pathogenic strains (mainly E. coli), respiratory pathogenic strains (mainly Pasteurellaceae), dermatological pathogenic strains (mainly S. intermedius, S. aureus) or other pets' bacteria (P. aeruginosa). Moreover, in the more recent publications [1,8,10] and others [11] the marbofloxacin activity was comparable with those obtained and was effective against others pets' pathogenic strains not studied by us, such as the Enterobacteriaceae, S. aureus, Salmonella spp. and Bordetella bronchiseptica.…”

“…Two other populations of strains with reduced susceptibility to marbofloxacin were observed. These less susceptible strains were observed before the launch of marbofloxacin suggesting that previously marketed fluoroquinolones had contributed to the emergence of less susceptible or resistant strains by co-or cross-selection pressure In 1998, a comparative in vitro susceptibility of 140 E. coli field strains isolated in Germany had an MIC 90 of 2 mg/l for enrofloxacin and marbofloxacin and 16 mg/l for difloxacin with a FQ-resistant strains subpopulation present in E. coli isolates [8]. The contribution of marbofloxacin to the emergence and spread of resistant E. coli isolated from urinary infections is limited although after an oral administration 62 and 68% of marbofloxacin is eliminated via the urinary tract in dogs and in cats, respectively.…”

Fluoroquinolone Resistance in Invasive Streptococcus pyogenes Isolates Due to Spontaneous Mutation and Horizontal Gene Transfer

“…The species S. dysgalactiae consists of two subpopulations of human and animal (particularly porcine and bovine) origin. A study by Meunier and coworkers addresses the prevalence of FQ resistance in bovine S. dysgalactiae (9). MICs of marbofloxacin, an FQ for individual administration to animals, were determined.…”

Mutations in GyrA and ParC in Fluoroquinolone-Resistant Mannheimia haemolytica Isolates from Cattle in Japan

“…However, we observed emergence of fluoroquinolone-resistant M. haemolytica in 2004 in our surveys (unpublished data). In Europe, the resistance rate of M. haemolytica against marbofloxacin has increased since the launch of marbofloxacin in 1997 [6]. The major mechanism of fluoroquinolone resistance is mutations of the quinolone resistance-determining regions (QRDRs) in DNA-gyrase (encoded by the gyrA and gyrB genes) and Topoisomerase IV (encoded by parC and parE) [3].…”