Seven-year clinical outcomes after collagenase injection in patients with Dupuytren's disease: A prospective study

Vitis, Rocco De; Passiatore, Marco; Perna, Andrea; Careri, Silvia; Cilli, V; Taccardo, Giuseppe

doi:10.1016/j.jor.2020.03.028

Cited by 13 publications

(9 citation statements)

References 27 publications

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“…Owing to the important wound complications following open surgery, less invasive techniques, such as percutaneous screw fixation, have been largely used over the last few years to stabilize the posterior pelvic ring and lumbo-sacral junction while reducing complications [44][45][46][47][48][49][50].…”

Section: Treatment and Complications Of Pelvic Ring Injuriesmentioning

confidence: 99%

Epidemiology and aetiology of male and female sexual dysfunctions related to pelvic ring injuries: a systematic review

Rovere

Perna

Meccariello³

et al. 2021

International Orthopaedics (SICOT)

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Introduction Pelvic ring injuries, frequently caused by high energy trauma, are associated with high rates of morbidity and mortality (5–33%), often due to significant blood loss and disruption of the lumbosacral plexus, genitourinary system, and gastrointestinal system. The aim of the present study is to perform a systematic literature review on male and female sexual dysfunctions related to traumatic lesions of the pelvic ring. Methods Scopus, Cochrane Library MEDLINE via PubMed, and Embase were searched using the keywords: “Pelvic fracture,” “Pelvic Ring Fracture,” “Pelvic Ring Trauma,” “Pelvic Ring injury,” “Sexual dysfunction,” “Erectile dysfunction,” “dyspareunia,” and their MeSH terms in any possible combination. The following questions were formulated according to the PICO (population (P), intervention (I), comparison (C), and outcome (O)) scheme: Do patients suffering from pelvic fracture (P) report worse clinical outcomes (C), in terms of sexual function (O), when urological injury occurs (I)? Is the sexual function (O) influenced by the type of fracture (I)? Results After screening 268 articles by title and abstract, 77 were considered eligible for the full-text analysis. Finally 17 studies that met inclusion criteria were included in the review. Overall, 1364 patients (902 males and 462 females, M/F ratio: 1.9) suffering from pelvic fractures were collected. Discussion Pelvic fractures represent challenging entities, often concomitant with systemic injuries and subsequent morbidity. Anatomical consideration, etiology, correlation between sexual dysfunction and genitourinary lesions, or pelvic fracture type were investigated. Conclusion There are evidences in the literature that the gravity and frequency of SD are related with the pelvic ring fracture type. In fact, patients with APC, VS (according Young-Burgess), or C (according Tile) fracture pattern reported higher incidence and gravity of SD. Only a week association could be found between GUI and incidence and gravity of SD, and relationship between surgical treatment and SD. Electrophysiological tests should be routinely used in patient suffering from SD after pelvic ring injuries.

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Section: Treatment and Complications Of Pelvic Ring Injuriesmentioning

confidence: 99%

Epidemiology and aetiology of male and female sexual dysfunctions related to pelvic ring injuries: a systematic review

Rovere

Perna

Meccariello³

et al. 2021

International Orthopaedics (SICOT)

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“…These modi cations produced a reduction of surgical exposure because the tendon to be prepared is much smaller, and a reduction of surgical times guaranteeing excellent results in terms of pain reduction, maintenance of strength and global function given that compared to a simple trapeziectomy, promoting rapid functional recovery, with excellent patient satisfaction. [12,13,27,28] In this work, we perform a comparison between trapeziectomy + LRTI/OLA (the APL subunit is looped around the FCR from palmar to dorsal at the bottom of the surgical eld and trapeziectomy + LRTI/OLI (the APL subunit is looped inside the FCR from palmar to dorsal at the bottom of the surgical eld). The risk of adhesion in both OLA and OLI LRTI is lowest than in other LRTI because incision and dissection is shorter performing a hemi-resection of APL and only one loop than in technique with double loop (Ceruso's technique).…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment of carpometacarpal thumb arthritis with trapeziectomy and intra-tendon (FCR) suspension with one-loop APL: comparative cohort study.

Passiatore

Taccardo

Cilli

et al. 2022

Preprint

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Background: One of the currents choices of treatment for Trapeziometacarpal (TMC) joint arthritis is trapeziectomy with ligament reconstruction and tendon interposition arthroplasty. The original Ceruso’s technique consists in complete trapezial excision and abductor pollicis longus (APL) tendon suspension. APL tendon is tied to the flexor carpi radialis (FCR) tendon with two loops, one around it and one inside, and then used as interposition tissue. The purpose of the present study was to compare two different techniques of trapeziectomy with ligament reconstruction and tendon interposition arthroplasty using the Abductor Pollicis Longus (APL) tendon, which is only Once Looped Around (OLA) versus Once Looped Inside (OLI) the Flexor Carpi Radialis (FCR) tendon. Methods The present retrospective one-center study (Level of evidence: III) has been conducted on sixty-seven patients aged more than 55 years (33 OLI, 35 OLA), assessing clinical outcomes at least 2 years follow-up. The outcomes were to assess and compare surgical outcomes comparing the two groups, in terms of subjective and objective evaluation for both groups at the last follow-up (primary outcome), and at the intermediate follow-ups (three and six months). Complications were also assessed. Results The authors found an improvement in pain, range of motion, and function, with equivalent results with both techniques. None subsidence was observed. FCR tendinitis was significantly reduced with OLI, as well as the need of post-operative physiotherapy. Conclusions The one-loop technique allows for reduced surgical exposure, providing excellent suspension and clinical outcomes. Intra FCR loop should be preferred to improve post-surgical recovery.

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“…In four out of the six CCH injection studies [ 26 , 36 , 38 , 39 ], patient satisfaction was measured using baseline and final follow-up Quick DASH, URAM, Hand 10, and EQ-VAS scores, consistently revealing increased patient satisfaction across all scores as outlined in Table 6 . In particular, the mean baseline Quick DASH score for 141 patients in three of the CCH injection studies was 20.91, with a mean final follow-up score of 8.36, signifying a significant improvement in satisfaction (39.9%), regardless of the follow-up duration.…”

Section: Reviewmentioning

confidence: 99%

Comparing Complications and Patient Satisfaction Following Injectable Collagenase Versus Limited Fasciectomy for Dupuytren’s Disease: A Systematic Review and Meta-Analysis

Alhebshi,

Bamuqabel,

Alqurain

et al. 2024

Cureus

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Dupuytren's disease (DD) is a fibroproliferative disorder that manifests as an abnormal growth of myofibroblasts, causing nodule formation and contractures and affecting digit function. If left untreated, these contractures can lead to a loss of mobility and potentially impact hand function. This systematic review critically compares and evaluates the existing literature on the complications and patient satisfaction following injectable collagenase Clostridium histolyticum (CCH) versus limited fasciectomy (LF) for DD. We performed a comprehensive search of the PubMed, Medical Literature Analysis and Retrieval System Online (MEDLINE), The Cochrane Library, and Excerpta Medica database (EMBASE) databases from 2006 to August 2023. This research targeted all clinical studies involving adults who underwent injectable collagenase and/or limited fasciectomy in the management of DD. Out of the 437 identified studies, only 53 were considered eligible for our analysis, and merely 14 met our inclusion criteria. These selected studies encompassed a total of 967 patients with 1,344 treated joints, with an average follow-up duration of 19.22 (ranging from one to 84.06) months. Within this cohort, 498 joints from 385 patients underwent LF, while 846 joints from 491 patients received CCH injections. Notably, among the 491 patients treated with CCH, 1,060 complications were reported, averaging 2.15 complications per patient, with the most common being contusion/bruising/hematoma/ecchymosis (22.54%), and edema/swelling (18.96%). In contrast, among the 385 patients treated with LF, only 97 complications were reported, translating to 0.25 complications per patient, with the most frequent being paraesthesia or numbness (23.7%), scar sequelae like skin laceration, tear, fissure, or hypertrophic scar (23.7%), and neuropraxia or nerve injury (22.6%). Our meta-analysis indicates that paraesthesia or numbness is more frequently observed in LF than CCH injections, although without statistical significance, with a risk ratio (RR) of 0.39 (95% confidence interval (CI) 0.13-1.18, p-value 0.1). However, scar sequelae (hypertrophic scar, skin laceration, tear, or fissure) show a contrasting pattern, being more commonly associated with CCH injections than LF, with an RR of 1.98 (95% CI 0.26-14.85, p-value 0.51), which, upon eliminating the source of heterogeneity, becomes statistically significant, with an RR of 4.98 (95% CI 1.40-17.72, p-value 0.01). Our data revealed a higher frequency of complications with CCH compared to LF, although more severe adverse effects were observed in the LF group, such as neuropraxia or nerve injury. Scar sequelae were more common with CCH injections. Despite both treatments showing increased patient satisfaction at the final follow-up, CCH injection resulted in earlier improvements in satisfaction.

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Seven-year clinical outcomes after collagenase injection in patients with Dupuytren's disease: A prospective study

Cited by 13 publications

References 27 publications

Epidemiology and aetiology of male and female sexual dysfunctions related to pelvic ring injuries: a systematic review

Epidemiology and aetiology of male and female sexual dysfunctions related to pelvic ring injuries: a systematic review

Surgical treatment of carpometacarpal thumb arthritis with trapeziectomy and intra-tendon (FCR) suspension with one-loop APL: comparative cohort study.

Comparing Complications and Patient Satisfaction Following Injectable Collagenase Versus Limited Fasciectomy for Dupuytren’s Disease: A Systematic Review and Meta-Analysis

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