seven-up Controls Switching of Transcription Factors that Specify Temporal Identities of Drosophila Neuroblasts

Kanai, Makoto I.; Okabe, Masataka; Hiromi, Yasushi

doi:10.1016/j.devcel.2004.12.014

Cited by 149 publications

(181 citation statements)

References 41 publications

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“…The orphan nuclear receptor Seven-up (Svp) is also necessary for this important transition to occur (Kanai et al 2005). Svp is expressed transiently within neuroblasts, coinciding with the downregulation of Hb.…”

Section: Specification Of Temporal Identitymentioning

confidence: 99%

Insights into neural stem cell biology from flies

Egger

Chell

Brand

2007

Phil. Trans. R. Soc. B

132

126

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Drosophila neuroblasts are similar to mammalian neural stem cells in their ability to self-renew and to produce many different types of neurons and glial cells. In the past two decades, great advances have been made in understanding the molecular mechanisms underlying embryonic neuroblast formation, the establishment of cell polarity and the temporal regulation of cell fate. It is now a challenge to connect, at the molecular level, the different cell biological events underlying the transition from neural stem cell maintenance to differentiation. Progress has also been made in understanding the later stages of development, when neuroblasts become mitotically inactive, or quiescent, and are then reactivated postembryonically to generate the neurons that make up the adult nervous system. The ability to manipulate the steps leading from quiescence to proliferation and from proliferation to differentiation will have a major impact on the treatment of neurological injury and neurodegenerative disease.

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Section: Specification Of Temporal Identitymentioning

confidence: 99%

Insights into neural stem cell biology from flies

Egger

Chell

Brand

2007

Phil. Trans. R. Soc. B

132

126

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“…This suggests that Svp normally interferes with Hb activity in the NB after the birth of the first GMC, thereby defining the fate of the second GMC. 24,25 Indeed, when we analysed stg mutant embryos we found that NBs which express svp mRNA exhibit a significantly lower Hb expression as compared to those that do not have svp. 25 Thus, low Svp activity might be necessary to discriminate between two Hb-dependent identities of specific NBs (Fig.…”

Section: Low Svp Translation Before Mitosis Might Be Responsible For mentioning

confidence: 91%

“…12 We and others have shown recently that the Hb to Kr transition is mediated by Seven-up, an orphan nuclear receptor which is homologous to vertebrate COUP transcription factors 24,25 (Fig. 1).…”

Section: Downregulation Of Hunchback Is a Mitosis-dependent Mechanismmentioning

confidence: 97%

“…Hence, Svp activity cannot be regulated on transcriptional level. 24,25 Instead, the localisation of svp mRNA seems to be the subject of mitosis-dependent regulation. In embryos mutant for string (stg), which encodes a CDC25 phosphatase involved in the regulation of the G 2 /M transition, 26 all NBs are arrested before their first cell division.…”

Section: Downregulation Of Hunchback Is a Mitosis-dependent Mechanismmentioning

confidence: 99%

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Connecting Temporal Identity to Mitosis: The Regulation of Hunchback in Drosophila Neuroblast Lineages

Urban

Mettler²

2006

Cell Cycle

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Both in vertebrates and invertebrates, neural stem cells generate different cell types at different times during development. It has been suggested that this process depends on temporal identity transitions of neural progenitors, but the underlying mechanism has not been resolved, yet. Recently, Drosophila neuroblasts (NBs) have been shown to be an excellent model system to investigate this subject. Here, changes in temporal identity are regulated by sequential and transient expression of transcription factors in the NB, such as Hunchback (Hb) and Krüppel (Kr). The temporal expression profile is maintained in the progeny. Hb is expressed first and thus defines the earliest identity in a given lineage. Transition to Kr requires the termination of hb expression, which occurs in response to mitosis, and is mediated by Seven-up (Svp). Recent results provided evidence that the dependency of Svp activity on mitosis could be due to an inhibition of the nuclear export of svp mRNA. Furthermore, the maintenance of hb expression in the GMC is regulated by the activity of Prospero (Pros), a transcription factor which asymmetrically segregates into the GMC during mitosis and inhibits Svp activity on both, the transcriptional and posttranscriptional level. These results give first insights as to how temporal cell fate specification can be correlated with mitosis.

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“…The temporal transcription factor cascade is Hunchback (Hb; Ikaros in mammals), Kruppel (Kr), Nubbin/Pou domain 2 (Pdm), and Castor (Casz1 in mammals). Loss of Hb or Kr leads to failure to specify the neurons born during these expression windows, whereas forced misexpression of Hb or Kr results in ectopic first-born or second-born neuron subtypes, 17,18,19 in part by Hb positively regulating its own expression. 20 However, pulses of Hb or Kr later in the embryonic neuroblast lineages fail to induce early neuronal fates: the neuroblast has lost competence to respond to these transcription factors.…”

Section: Drosophilamentioning

confidence: 99%

Opportunities lost and gained: Changes in progenitor competence during nervous system development

Farnsworth

Doe

2017

Neurogenesis

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During development of the central nervous system, a small pool of stem cells and progenitors generate the vast neural diversity required for neural circuit formation and behavior. Neural stem and progenitor cells often generate different progeny in response to the same signaling cue (e.g. Notch or Hedgehog), including no response at all. How does stem cell competence to respond to signaling cues change over time? Recently, epigenetics particularly chromatin remodeling -has emerged as a powerful mechanism to control stem cell competence. Here we review recent Drosophila and vertebrate literature describing the effect of epigenetic changes on neural stem cell competence.

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seven-up Controls Switching of Transcription Factors that Specify Temporal Identities of Drosophila Neuroblasts

Cited by 149 publications

References 41 publications

Insights into neural stem cell biology from flies

Insights into neural stem cell biology from flies

Connecting Temporal Identity to Mitosis: The Regulation of Hunchback in Drosophila Neuroblast Lineages

Opportunities lost and gained: Changes in progenitor competence during nervous system development

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