Seven Novel Genes Related to Cell Proliferation and Migration of VHL-Mutated Pheochromocytoma

Gao, Shuai; Liu, Longfei; Li, Zhuolin; Pang, Yingxian; Shi, Jiaqi; Zhu, Fenlu

doi:10.3389/fendo.2021.598656

Cited by 6 publications

(5 citation statements)

References 75 publications

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“…The limitations of our study, including the retrospective design and the lack of consideration of genomic characteristics, should be taken into account. In recent years, a growing amount research on PCC gene mutations, such as VHL and SDH [34][35][36][37][38], has been done. Recently, the relationship between genomics and angiogenesis/metastasis has emanated in PCC studies.…”

Section: Discussionmentioning

confidence: 99%

Hemorrhage in pheochromocytoma surgery: evaluation of preoperative risk factors

Guo

Xie

et al. 2022

Endocrine

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Objective Pheochromocytoma surgery carries a higher risk of hemorrhage. Our objective was to identify preoperative risk factors for hemorrhage during pheochromocytoma surgery. Methods Patients who underwent surgery and with postoperative pathological confirmation were enrolled. A total of 251 patients from our center were included in the investigation, and 120 patients from the First Affiliated Hospital, Sun Yat-sen University were included as an external validation dataset. Family and medical history, demographics, hemodynamics, biochemical parameters, image data, anesthesia and operation records, postoperative outcomes were collected. Postoperative complications were graded by the Clavien–Dindo classification. Correlation between intraoperative hemorrhage volume and postoperative outcomes was assessed. The features associated with intraoperative hemorrhage were identified by linear regression. All features that were statistically significant in the multiple linear regression were then used to construct models and nomograms for predicting intraoperative hemorrhage. The constructed models were evaluated by Akaike Information Criterion. Finally, internal and external validations were carried out by tenfold cross-validation. Results Intraoperative hemorrhage volume was positively correlated with the postoperative hospitalization time (R = 0.454, P < 0.001) and the Clavien–Dindo grades (R = 0.664, P < 0.001). Features associated with intraoperative hemorrhage were male gender (β = 0.533, OR = 1.722, P = 0.002), tumor diameter (β = 0.027, OR = 1.027, P < 0.001), preoperative CCB use (β = 0.318, OR = 1.308, P = 0.123) and open surgery (β = 1.175, OR = 3.234, P < 0.001). Validations showed reliable results (internal (R = 0.612, RMSE = 1.355, MAE = 1.111); external (R = 0.585, RMSE = 1.398, MAE = 0.964)). Conclusion More intraoperative hemorrhage is correlated with longer postoperative hospitalization time and more severe postoperative complications. Male gender, larger tumor, preoperative CCB use and open surgery are preoperative risk factors for hemorrhage in PCC surgery.

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Section: Discussionmentioning

confidence: 99%

Hemorrhage in pheochromocytoma surgery: evaluation of preoperative risk factors

Guo

Xie

et al. 2022

Endocrine

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“…(AK1, CLU, CKB, CNN1, DES, FNDC1, GNAI2, GNG10, LGALS, LYN, P3H4, PTK7, RPM3, S100A4, SYNM, SYNPO2, TAGLN, SERPIN1, SERPINB1, VWA1) and 6 that are specifically upregulated in non-hepatobiliary NENs (CKB, CLU, LGALS1, LYN, SERPINB1, TAGLN) [25,[30][31][32][33][34][35][36]. Of these, transgelin (TAGLN) and galectin-1 (LGALS1) protein expression were validated in canine NENs by immunohistochemistry (S1 and S2 Figs).…”

Section: Plos Onementioning

confidence: 99%

Neoplastic signatures: Comparative proteomics of canine hepatobiliary neuroendocrine tumors to normal niche tissue

Batts

Sasaki²,

Miller

et al. 2023

PLoS ONE

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Hepatobiliary neuroendocrine neoplasms are rare cancers in humans and dogs. To date, no large-scale primary hepatobiliary neoplasm omics analyses exist in any species. This limits the development of diagnostic biomarkers and targeted therapeutics. Neuroendocrine cancers are a heterogenous group of neoplasms categorized by their tissue-of-origin. Because the anatomic niche of neuroendocrine neoplasms shapes tumor phenotype, we sought to compare the proteomes of 3 canine hepatobiliary neoplasms to normal hepatobiliary tissue and adrenal glands with the objective of identifying unique protein signatures. Protein was extracted from formalin-fixed paraffin-embedded samples and submitted for tandem mass spectroscopy. Thirty-two upregulated and 126 downregulated differentially expressed proteins were identified. Remarkably, 6 (19%) of the upregulated proteins are correlated to non-hepatobiliary neuroendocrine neoplasia and 16 (50%) are functionally annotated within the exosome cellular compartment key to neuroendocrine signaling. Twenty-six (21%) downregulated proteins are enriched in metabolic pathways consistent with alterations in cancer. These results suggests that characteristic neoplastic protein signatures can be gleaned from small data sets using a comparative proteomics approach.

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“…In addition, in urothelial cell carcinoma, syntenin-1 regulates the proliferation and invasion by modeling the signaling pathway of EGFR, AKT, PI3K, and c-Src, as well as the progression of EMT by the alteration in the expression of β-catenin, E-cadherin, vimentin, Claudin-1, ZO-1, and TCF4 [ 103 ]. In pheochromocytoma, syntenin-1 has been related to the complex COL3A1, COL5A2, and SERPINE1 [ 104 ]. Finally, syntenin-1 can modulate the internalization of the oncogenic human papillomavirus (HPV) in complex with CD63 [ 105 ].…”

Section: Syntenin-1mentioning

confidence: 99%

Biological Role and Aberrant Overexpression of Syntenin-1 in Cancer: Potential Role as a Biomarker and Therapeutic Target

et al. 2023

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Syntenin-1 is a 298 amino acid protein codified by the melanoma differentiation-associated gene-9 (MDA-9). Structurally, it is composed of four domains: N-terminal, PDZ1, PDZ2, and C-terminal. The PDZ domains of syntenin-1 are involved in the stability and interaction with other molecules such as proteins, glycoproteins, and lipids. Domains are also associated with several biological functions such as the activation of signaling pathways related to cell-to-cell adhesion, signaling translation, and the traffic of intracellular lipids, among others. The overexpression of syntenin-1 has been reported in glioblastoma, colorectal, melanoma, lung, prostate, and breast cancer, which promotes tumorigenesis by regulating cell migration, invasion, proliferation, angiogenesis, apoptosis, and immune response evasion, and metastasis. The overexpression of syntenin-1 in samples has been associated with worst prognostic and recurrence, whereas the use of inhibitors such as shRNA, siRNA, and PDZli showed a diminution of the tumor size and reduction in metastasis and invasion. Syntenin-1 has been suggested as a potential biomarker and therapeutic target in cancer for developing more effective diagnostic/prognostic tests or passive/active immunotherapies.

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Seven Novel Genes Related to Cell Proliferation and Migration of VHL-Mutated Pheochromocytoma

Cited by 6 publications

References 75 publications

Hemorrhage in pheochromocytoma surgery: evaluation of preoperative risk factors

Hemorrhage in pheochromocytoma surgery: evaluation of preoperative risk factors

Neoplastic signatures: Comparative proteomics of canine hepatobiliary neuroendocrine tumors to normal niche tissue

Biological Role and Aberrant Overexpression of Syntenin-1 in Cancer: Potential Role as a Biomarker and Therapeutic Target

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