Seven New Sesquiterpene Lactones from Eupatorium chinense

Abstract

Seven new sesquiterpenoids, namely eupatochinilides I-VII (1-7), together with eight known compounds, euponin (8), mollisorin A (9), niveusin B (10), 8β-(4'-acetoxy-tiglyloxy)-3β-hydroxy-6H β ,7H α -germacra-1(10)E,4E,11(13)-trien-6,12-olide (11), eupalinilide B (12), 8β-(4'-hydroxytigloyloxy)-5-desoxy-8-desacyleuparotin (13), 3-deacetyeupalinin A (14), and 15-hydroxyleptocarpin (15), were isolated from the ethanolic extract of the whole plant of Eupatorium chinense L. Their structures and stereochemistry were established by spectroscopic methods and GIAO based 13 C NMR chemical shift calculations.

Targeting pharmacophore with probe‐reactivity‐guided fractionation to precisely identify electrophilic sesquiterpenes and its activity of anti‐TNBC

“…The 11 compounds all have electrophilic groups and are typical ESs. They were identified as ( E )‐(4 R ,6 Z ,9 S ,10 E ,11a R )‐9‐hydroxy‐6,10‐dimethyl‐3‐methylene‐2‐oxo‐2,3,3a,4,5,8,9,11a‐octahydrocyclodeca[b]furan‐4‐yl( Z )‐2‐(acetoxymethyl)but‐2‐enoate ( 1 ), (3 S ,6 R ,7 R ,8 R )‐3‐hydroxy‐8‐acetoxysarracenyloxygermacra‐1(10),4,11(13)‐trien‐6,12‐olide ( 2 ), eupachifolin‐E ( 3 ), eupachifolin‐B ( 4 ), 3β‐ethoxy‐leptocarpin ( 5 ), eupachinilide C ( 6 ), eupachinilide I ( 7 ), 8β‐[4′‐hydroxytigloyloxy]‐5‐desoxy‐8‐desacyleuparotin ( 8 ), dacetyleupaserrin ( 9 ), 2‐hydroxyeupatolide ( 10 ), mollisorin B ( 11 ) …”

The genus Eupatorium L. (Asteraceae): A review of their antimicrobial activity

“…] an annual herbal plant, native to Asia is distributed in the south of China, used in Chinese folk medicine for the treatment of cold, snakebite and inflammation (Yang et al, 2005). The antidermatophytic activity of this plant species was tested against the fungus, T. mentagrophytes, using the ethyl acetate extract of the leaves and flowers at a concentration of 0.25 mg/mL.…”