Seven-membered Rings with Three Heteroatoms 1,3,5

Denisko, Olga V.

doi:10.1016/b978-008044992-0.01216-5

Cited by 2 publications

(2 citation statements)

References 261 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…b) Thiadiazepine: The seven membered thiadiazepine can be obtained by reaction of compound (67) i.e. 8-(alkylthio)xanthine that have 1,3-dicarbonyl moiety with phosphorous pentachloride (68) lead to the formation of chloroimidate which then converted to tricyclic compound (69) through cyclization process as described in scheme 22 (36). Scheme 22.…”

Section: Synthesis Of Seven Membered Ringsmentioning

confidence: 99%

Synthesis of Heterocyclic Compounds Via 1,3-Diketones

Sharma¹,

Sharma²,

Kapoor³

2022

ECS Trans.

View full text Add to dashboard Cite

Heterocyclic compounds acquire a unique place in medicinal chemistry as many of the pharmaceuticals, agrochemical industries use heterocyclic moieties in different kinds of drugs. Moreover, many of these compounds are naturally occurring and are known for their antibacterial properties from ancient times. These compounds like thiazole, pyrazole, imidazole, coumarin etc. are synthesized via 1,3-dicarbonyls as an intermediate. Essentially β-dicarbonyls are considered as promising scaffolds for the synthesis of heterocyclic compounds. Especially, due to keto-enol tautomerism, β-diketones show very distinct chemical properties. They could be made by combining an adequate methyl ketone with an acceptable ethyl ester in a Claisen reaction, which allows for a large range of potential combinations. In this review, we will discuss various synthetic approaches for the preparation of five and six membered heterocyclic compounds via 1,3-dicarbonyls.

show abstract

Section: Synthesis Of Seven Membered Ringsmentioning

confidence: 99%

Synthesis of Heterocyclic Compounds Via 1,3-Diketones

Sharma¹,

Sharma²,

Kapoor³

2022

ECS Trans.

View full text Add to dashboard Cite

show abstract

“…8,9 They have emerged as antibacterial, antiproliferation, anticancer, and anticonvulsant activities. [1][2][3][4][5][10][11][12] Numerous studies have been reported [13][14][15][16][17][18][19][20][21][22][23][24] on the synthesis of a variety of oxadiazepine derivatives covering a wide range of bioorganic, natural products, and medicinal chemistry. They are an important class of heterocyclic compounds that have pharmaceutical and biological activities 13,[21][22][23][24] including antiherbicide, antimicrobial, antifungal, and anticancer.…”

Section: Introductionmentioning

confidence: 99%