Seven-Membered Rings

Meyer, Adam G.; Bissember, Alex C.; Hyland, Christopher J. T.; Smith, Jason A.; Williams, Charlotte C.; Zamani, Farzad; Abel, Steven-Alan G.

doi:10.1016/b978-0-08-102310-5.00016-3

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Cited by 7 publications

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“…The benzazepine skeleton is a privileged scaffold in terms of biological activity (Figure ). However, access to structural diversity around this scaffold is limited by the availability of general methods for the synthesis of benzazepines, since classical approaches largely rely on multistep strategies . The asymmetric synthesis of benzazepines is even more underexplored …”

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confidence: 99%

Access to Benzazepinones by Pd-Catalyzed Remote C–H Carbonylation of γ-Arylpropylamine Derivatives

et al. 2019

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A general method for the construction of sevenmembered rings through Pd-catalyzed C(sp 2 )−H carbonylation at the remote ε-position of γ-arylpropylamine derivatives, including chiral α-amino acids, has been developed using Mo(CO) 6 as the CO source, furnishing richly functionalized benzo[c]azepin-1-one derivatives. The readily removable N-SO 2 Py protecting/directing group provides high levels of chemo-, regio-and diastereoselectivity. Furthermore, this method is amenable to the postsynthetic modification of complex molecules such as small peptides.

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confidence: 99%