Sevelamer-associated ischemic colitis with perforation

Hudacko, Rachel; Kaye, P.V.

doi:10.4081/gi.2015.6116

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…40 Reports have also associated sevelamer hydrochloride and sevelamer carbonate with intestinal perforation in a small number of cases. 41 The presence of sevelamer "crystals" was identified within the affected tissue in each reported case. The observation of gastrointestinal symptoms associated with sevelamer hydrochloride was suggested in one report to be due to swelling of the polymer in the GI tract.…”

Section: Side Effects Of Polymer Bindersmentioning

confidence: 78%

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Polymers as drugs—Advances in therapeutic applications of polymer binding agents

Connor

Lees²,

Maclean³

2017

J. Polym. Sci. Part A: Polym. Chem.

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Polymer drugs are those in which a polymer agent has a direct therapeutic effect on the body. A major investigated area of polymer drugs is their use as binding agents, or sequestrants, which can neutralize or remove undesired components from the body. By taking advantage of the unique properties of crosslinked, insoluble polymers, new polymer drugs continue to be developed for oral use, acting in the gastrointestinal tract and excreted in the feces. Soluble polymer binders may be administered by a variety of routes and act at diverse sites of therapeutic action. This article reviews the properties of polymer drugs, particularly sequestrants, with an emphasis on recent advances in polymer properties which may enhance the utility of this class of drugs. V C 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 3146-3157 KEYWORDS: polymer binders; polymer drugs; polymer pharmaceuticals; polymer sequestrant; synthetic macromolecular drugs INTRODUCTION Polymers have a wide range of applications in the field of therapeutic development. This article describes polymer drugs in which a polymeric species directly effects the desired pharmacology, and the polymer itself is considered to be the active pharmaceutical ingredient. This is in contrast to the wide usage of polymers that function as excipients (e.g., coatings, viscosifiers, surfactants, etc.), that improves the performance of the pharmaceutical product (active pharmaceutical ingredient) without direct, intrinsic pharmacologic effect.

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Section: Side Effects Of Polymer Bindersmentioning

confidence: 78%

“…Reports have also associated sevelamer hydrochloride and sevelamer carbonate with intestinal perforation in a small number of cases . The presence of sevelamer “crystals” was identified within the affected tissue in each reported case.…”

Section: Polymer Drugsmentioning

confidence: 85%

Polymers as drugs—Advances in therapeutic applications of polymer binding agents

Connor

Lees²,

Maclean³

2017

J. Polym. Sci. Part A: Polym. Chem.

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“…Several recently published case reports have demonstrated the association of sevelamer crystals with ischemic colitis, colonic perforation, and pseudotumor 8,9. Given the varying clinical manifestations of sevelamer-induced GI mucosal injury, it is important for clinicians, surgeons, and pathologists to be aware of the potential GI complications associated with sevelamer use to avoid catastrophic complications and significant patient morbidity and mortality by early withdrawal of the offending medication.…”

Section: Discussionmentioning

confidence: 99%

Sevelamer-Associated Rectosigmoid Ulcers in an End-Stage Renal Disease Patient

Uy¹,

Vinsard²,

Hafeez³

2018

ACG Case Reports Journal

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Sevelamer carbonate is a commonly prescribed anion-exchange resin administered orally to prevent hyperphosphatemia in patients with chronic kidney disease. We present a rare case of a 33-year-old man with end-stage renal disease and diabetic gastroparesis on sevelamer carbonate, who presented with hematochezia and was found to have rectosigmoid ulcers induced by sevelamer crystals. His hematochezia resolved after switching from sevelamer carbonate to lanthanum carbonate. Clinicians and pathologists must be aware of the possibility of drug-induced mucosal ulceration associated with sevelamer use as a potential etiology of a gastrointestinal bleed.

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Sevelamer

2016

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Sevelamer-associated ischemic colitis with perforation

Cited by 5 publications

References 4 publications

Polymers as drugs—Advances in therapeutic applications of polymer binding agents

Polymers as drugs—Advances in therapeutic applications of polymer binding agents

Sevelamer-Associated Rectosigmoid Ulcers in an End-Stage Renal Disease Patient

Sevelamer

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