Setting Properties of Calcium Phosphate Bone Cement

Fathi, Majda; Kholtei, Abdelilah; Youbi, S. El; Idrissi, Brahim Chafik El

doi:10.1016/j.matpr.2019.04.051

Cited by 15 publications

(11 citation statements)

References 9 publications

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“…A critical difference of CPC from PMMA is that CPC is progressively resorbed by osteoblasts over days to weeks, resulting in new bone, whereas PMMA is inert and will inevitably lead to a fibrous layer between itself and bone, never to be replaced with bone [19]. While the prospect of a biologically viable "cement" is exciting, unfortunately no CPC formulation is currently approved for weight-bearing situations [20].…”

Section: Discussionmentioning

confidence: 99%

Cementing Osseointegration Implants Results in Loosening: Case Report and Review of Literature

Hoellwarth

Muderis

Rozbruch

2020

Cureus

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Skeletal transcutaneous osseointegration was performed on a 54-year-old female transfemoral amputee. None of the available osseointegration implants achieved press-fit stability, so an implant was cemented in position. Although initially stable, by six months the patient reported painful loading and radiographs revealed cement mantle lucency. The osseointegration implant was removed, antibiotics were delivered via implanted spacer and intravenously, and revision osseointegration three months later achieved appropriate immediate press-fit stability. Cemented transcutaneous osseointegration implants loosen within one year. Osseointegration is only successful when bone grows directly onto the implant.

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Section: Discussionmentioning

confidence: 99%

Cementing Osseointegration Implants Results in Loosening: Case Report and Review of Literature

Hoellwarth

Muderis

Rozbruch

2020

Cureus

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“…Despite a thermodynamically metastable species relative to HA, DCPD (also called brushite) has been widely applied to pathological calcifications and gentle polishing agents in toothpastes. − DCPD is also an important component of bone cement in bone repair due to its faster resorption than apatite. , Recently, a new CaP cement with a Ca/P ratio of 1.38, consisting of the mixed components of α-tricalcium phosphate, HA, and DCPD, was produced by the rapid addition of solution Ca(NO 3 ) 2 ·4H 2 O to the stirring solution (NH 4 ) 2 HPO 4 with pH = 4.5–5 at room temperature . DCPD could be easily crystallized in acid solutions (pH = 2.0–6.0) from aqueous solutions containing soluble calcium salts (Ca(NO 3 ) 2 ·4H 2 O, CaCl 2 ·2H 2 O, or Ca(CH 3 COO) 2 ·H 2 O) and phosphate salts (NH 4 H 2 PO 4 , (NH 4 ) 2 HPO 4 , Na 2 HPO 4 , NaH 2 PO 4 , KH 2 PO 4 , or K 2 HPO 4 ) ,,− at room temperature and a Ca/P ratio of 1.00.…”

Section: Introductionmentioning

confidence: 99%

“…32,33 Recently, a new CaP cement with a Ca/P ratio of 1.38, consisting of the mixed components of α-tricalcium phosphate, HA, and DCPD, was produced by the rapid addition of solution Ca(NO 3 ) 2 •4H 2 O to the stirring solution (NH 4 ) 2 HPO 4 with pH = 4.5−5 at room temperature. 32 DCPD could be easily crystallized in acid solutions (pH = 2.0−6.0) 4 from aqueous solutions containing soluble calcium salts (Ca(NO 3 ) 8,15,34−37 at room temperature and a Ca/P ratio of 1.00. The morphology of DCPD changed with additives, initial pH values, and ion concentrations.…”

Section: Introductionmentioning

confidence: 99%

Surface Stability and Morphology of Calcium Phosphate Tuned by pH Values and Lactic Acid Additives: Theoretical and Experimental Study

Chen

Guo

et al. 2022

ACS Appl. Mater. Interfaces

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The ubiquitous mineralization of calcium phosphate (CaP) facilitates biological organisms to produce hierarchically structured minerals. The coordination number and strength of Ca 2+ ions with phosphate species, oxygen-containing additives, and solvent molecules played a crucial role in tuning nucleation processes and surface stability of CaP under the simulated body fluid (SBF) or aqueous solutions upon the addition of oligomeric lactic acid (LACn, n=1, 8) and changing pH values. As revealed by ab initio molecular dynamics (AIMD), density functional theory (DFT), and molecular dynamics (MD) simulations as well as high-throughput experimentation (HTE), the binding of LAC molecules with Ca 2+ ions and phosphate species could stabilize both pre-nucleation clusters and brushite (DCPD, CaHPO4• 2H2O) surface through intermolecular electrostatic and hydrogen bonding interactions. When the concentration of Ca 2+ ions ([Ca 2+ ]) is very low, the amount of the formed precipitation decreased with the addition of LAC based on UV-Vis spectroscopic analysis due to the reduced chance for the LAC capped Ca 2+ ions to coordinate with phosphates and the increased solubility in acid solution. With the increasing [Ca 2+ ] concentration, the kinetically stable DCPD precipitation was obtained with high Ca 2+ coordination number and low surface energy. Morphologies of DCPD precipitation are in plate, needle, or rod, depending on the initial pH values that tuned by adding NH3•H 2O, HCl, or CH3COOH. The prepared samples at pH ≈ 7.4 with different Ca/P ratios exhibited negative zeta potential values, which were correlated with the surface electrostatic potential distributions and potential biological applications.3 INTRODUCTIONBones and teeth of vertebrates are known to come from mineralization of calcium phosphate (CaP) 1 through two possible nucleation processes, i.e., a classical aggregation or a two-step nucleation pathway. 2 The real nucleation process of CaP in biological conditions becomes much more complicated, attracting extensive interest both experimentally and theoretically.The first factor in controlling nucleation process of CaP is the pH value, which could affect the occurrence of different phosphate species, such as H3PO4 (called 3H for short), H2PO4 -(2H), HPO4 2-(1H), and PO4 3-(0H), shown in Figure 1a. Thus, properties of CaP precipitation, 3, 4 adsorption of organic acid 5 , phase composition 6 , morphology 7, 8 , zeta potentials [9][10][11][12] , and crystal size of CaP 13 could be varied with different pH values.Secondly, through the modulation of interfacial interaction and kinetic stability, the introduction of many kinds of additives, such as metal ions, acid or basic solutions, amino acids, dopamine, and citrate, could change the nucleation or phase transformation paths and morphologies 8, 14-19 . Starting from the ion pair CaHPO4 in a neutral or basic CaP solution, a Ca-deficient pre-nucleation cluster, Ca(HPO4)3 4-, is formed at the early stage of nucleation process. [20][21][22][23][24] Subsequently, those sm...

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“…Inorganic CPCs often have critical drawbacks that limit their possible clinical application, including a lack of injectability [ 12 , 13 ] that is generally characterized by phase separation during injection, low mechanical properties for the loading requirements of the implantation site [ 14 , 15 ] as well as a weak cohesion that results in the disintegration of the cement paste when in contact with physiological fluids [ 2 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

et al. 2021

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Calcium phosphate cements have the advantage that they can be prepared as a paste that sets in a few minutes and can be easily adapted to the shape of the bone defect, which facilitates its clinical application. In this research, six formulations of brushite (dicalcium phosphate dihydrated) cement were obtained and the effect of the addition of sodium alginate was analyzed, such as its capacity as a tetracycline release system. The samples that contain sodium alginate set in 4 or 5 min and showed a high percentage of injectability (93%). The cements exhibit compression resistance values between 1.6 and 2.6 MPa. The drug was released in a range between 12.6 and 13.2% after 7 days. The antimicrobial activity of all the cements containing antibiotics was proven. All samples reached values of cell viability above 70 percent. We also observed that the addition of the sodium alginate and tetracycline improved the cell viability.

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Setting Properties of Calcium Phosphate Bone Cement

Cited by 15 publications

References 9 publications

Cementing Osseointegration Implants Results in Loosening: Case Report and Review of Literature

Cementing Osseointegration Implants Results in Loosening: Case Report and Review of Literature

Surface Stability and Morphology of Calcium Phosphate Tuned by pH Values and Lactic Acid Additives: Theoretical and Experimental Study

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

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