Set-up and pilot of a population cohort for the study of the natural history of COPD and OSA: the PULSAIB study

Soriano, Joan B.; Yáñez, Aina M.; Renom, Feliu; Peña, Mónica de la; Gómez, Aixa San Emeterio; Duro, Rosa; Uréndez, Ana; Román, Miguel

doi:10.4104/pcrj.2010.00010

Cited by 16 publications

(10 citation statements)

References 27 publications

(24 reference statements)

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“…[3] Data from the Balearic Islands showed similar results, with a prevalence of 12.8% in this age group. [4] Pharmacologic and non-pharmacologic treatments can help to improve COPD control and symptoms and slow down disease progression. [1] In contrast to asthma, where inhaled corticosteroids (ICS) are the main pharmacological treatment, their efficacy and role in the treatment of COPD is less evident.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with inhaled corticosteroids prescription in primary care patients with COPD: A cross-sectional study in the Balearic Islands (Spain)

Román-Rodríguez

Boven

Vargas

et al. 2016

European Journal of General Practice

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KEY MESSAGESThe proportion of COPD patients with ICS prescriptions in Balearic primary care is lower than proportions observed in other studies. Asthma comorbidity, exacerbations, severe bronchial-obstruction, smoking status and spirometry-registered data were associated with ICS prescription. High-dose ICS prescription was associated with severe obstruction, exacerbations and co-morbid asthma. ABSTRACTBackground: There is a worldwide over-prescription of inhaled corticosteroids (ICS) in patients with chronic obstructive pulmonary disease (COPD), off-label prescribing, and unnecessary prescription of high doses. Objectives: Our aim was to assess the prescription rate of ICS and to identify sociodemographic and clinical factors associated with ICS prescription among patients with COPD, treated in Balearic primary healthcare. Methods: This cross-sectional study included all patients with a clinical COPD diagnosis, who attended a primary care centre of the Balearic Islands (Spain) during 2012. Also, a sub-population with spirometry-confirmed COPD was defined. Data were obtained on patient demographics, smoking status, spirometry, ICS prescriptions, other respiratory medication, exacerbations and comorbidities. Associations with ICS and high-dose ICS prescription were assessed using multivariate regression analyses. Results: In total, 15,440 patients were included (70% men, mean age 68.6 years), and 44.6% were prescribed ICS. The largest association with ICS prescription was asthma comorbidity (OR: 3.50; 95%CI: 3.12-3.92), followed by exacerbation history (OR: 2.23; 95%CI: 2.07-2.47). In addition, smoking status, spirometry, atopic dermatitis, allergic rhinitis and mean age were significantly (P < 0.001) associated with ICS treatment. In the spirometry-confirmed population, asthma (OR: 2.89; 95%CI: 2.29-3.64) and exacerbations were also the major factors (OR: 2.85; 95%CI: 2.45-3.32) followed by severe bronchial-obstruction (OR: 2.63; 95%CI: 2.24-3.08). High-dose ICS prescription was mainly associated with severe obstruction (OR: 2.27; 95%CI: 1.93-2.68). Conclusion: The percentage of COPD patients prescribed ICS in Balearic primary care is relatively low. Asthma comorbidity, exacerbation history, severe bronchial-obstruction, smoking status and a spirometry-confirmed COPD diagnosis were significantly associated with ICS prescription.

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Section: Introductionmentioning

confidence: 99%

Factors associated with inhaled corticosteroids prescription in primary care patients with COPD: A cross-sectional study in the Balearic Islands (Spain)

Román-Rodríguez

Boven

Vargas

et al. 2016

European Journal of General Practice

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“…Some Blue Zones might become extinct. All these factors likely interact and vary in time, making it difficult to study in depth the natural history of diseases in the community, respiratory or other …”

Section: Discussionmentioning

confidence: 99%

“…All these factors likely interact and vary in time, making it difficult to study in depth the natural history of diseases in the community, respiratory or other. 31,32 The forthcoming results of the Genetics of Healthy Ageing (GEHA) project 33 and other ongoing initiatives will be welcome. Furthermore, by engaging older members of the public and older patients in research, the generalizability of research findings will be improved.…”

Section: Discussionmentioning

confidence: 99%

Description of extreme longevity in the Balearic Islands: Exploring a potential Blue Zone in Menorca, Spain

Soriano

Vázquez

Carretero

et al. 2013

Geriatrics Gerontology Int

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“…OSA is a common respiratory disorder during sleep that characterized by apneas, and associated with a reduction in blood oxygen saturation. Each event of OSA typically lasts 20-40 seconds (18)(19)(20) and caused by obstruction of the upper airways (21). A recent assessment of polysomnography has shown that approximately onequarter to one-half of OSA patients are suffering from PLMD (22,23).…”

Section: Introductionmentioning

confidence: 99%

Impact of Continuous Positive Airway Pressure Treatment on Periodic Leg Movement Disorder in Patients with Obstructive Sleep Apnea Syndrome and Sulfur Mustard’s Lung Injury

Mousavi¹,

Vahedi²,

Shohrati³

et al. 2016

West Indian Med J

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Objective: Periodic limb movement disorder (PLMD) and obstructive sleep apnea (OSA) are prevalent sleep disorders in Sulfur Mustard (SM) patients. This study aimed to consider the relationship between PLMD frequency and arousal related to PLMD in SM-exposed and OSA patients before and after treatment with continuous positive airway pressure (CPAP). Methods: In this descriptive analytic study, SM-exposed male cases (n=64) with an age-matched group and OSA unexposed controls (n=64) were enrolled. OSA severity based on apnea hypopnea index (AHI), PLMI and PLM-arousal-index (PLMAI) was monitored between two groups in baseline and after CPAP or BiPAP treatment. Results: PLMD frequency in OSA and SM groups was 91.5% and 95.5%, respectively. In SM patients, there were statistical differences for PLMA (p = 0.01), PLMAI (p = 0.02), PLMS associated with respiratory events (p = 0.041), and PLMS without arousal and respiratory events (p = 0.001) after CPAP therapy. But in OSA group, PLMS index (p = 0.003), PLMS associated with respiratory events (p = 0.001), PLMS without arousal and respiratory events (p = 0.001) were significantly different after CPAP therapy. After receiving CPAP, sleep quality in both groups was increased significantly (SM: P = 0.006, OSA: P = 0.001). There were no significant differences between two groups. Conclusion: This study demonstrated that PLMD in SM patients was high and CPAP therapy reduced all these events significantly. This may represent a protective and maintenance Treatment against sleeprelated breathing disorders in SM-exposed patients.

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Set-up and pilot of a population cohort for the study of the natural history of COPD and OSA: the PULSAIB study

Cited by 16 publications

References 27 publications

Factors associated with inhaled corticosteroids prescription in primary care patients with COPD: A cross-sectional study in the Balearic Islands (Spain)

Factors associated with inhaled corticosteroids prescription in primary care patients with COPD: A cross-sectional study in the Balearic Islands (Spain)

Description of extreme longevity in the Balearic Islands: Exploring a potential Blue Zone in Menorca, Spain

Impact of Continuous Positive Airway Pressure Treatment on Periodic Leg Movement Disorder in Patients with Obstructive Sleep Apnea Syndrome and Sulfur Mustard’s Lung Injury

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