Sestrin2 in atherosclerosis

Tian, Zhen; Yan, Bin-Jie; Luo, Wen; Gui, Dan-Dan; Zhou, Kun; Tian, Kai-Jiang; Ma, Yun; Zhou, Zikang; Jiang, Zhi‐Sheng

doi:10.1016/j.cca.2021.10.019

Cited by 3 publications

(4 citation statements)

References 57 publications

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“…It functions as an intracellular nutrient sensor to control protein synthesis, cell growth, and metabolism [65][66][67]. A stress-inducing protein Sestrin2 serves as a guardian by activating AMPK, reducing mTOR, and keeping redox balance beneath various stress environments [68]. A previous study has elaborated that dapagliflozin activates AMPK and suppresses the phosphorylation of mTOR in Zucker diabetic fatty rats, thereby mitigating hepatic steatosis [69].…”

Section: Discussionmentioning

confidence: 99%

Sirtuin3 confers protection against acute pulmonary embolism through anti-inflammation, and anti-oxidative stress, and anti-apoptosis properties: participation of the AMP-activated protein kinase/mammalian target of rapamycin pathway

Han

Jia

et al. 2023

Exp. Anim.

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Increasing studies have suggested that oxidative stress and inflammation play momentous roles in acute pulmonary embolism (APE). Honokiol, a bioactive biphenolic phytochemical substance, is known for its strong anti-oxidative and antiinflammatory effects and here serves as an activator of sirtuin3 (SIRT3). The purposes of the study are to explore the effects of Honokiol on APE rats, and investigate whether the function of Honokiol is mediated by SIRT3 activation. In this study, the rats received a right femoral vein injection with dextran gel G-50 particles (12 mg/kg) to establish the APE model, which were administrated with Honokiol and/or selective SIRT3 inhibitor 3-(1H-1, 2, 3-triazol-4-yl) pyridine (3-TYP; 5 mg/kg) intraperitoneally. The data showed that SIRT3 activation by Honokiol attenuated the loss in lung function, ameliorated inflammatory response and oxidative damage as well as inhibited apoptosis in lung tissues of the rats with APE, which was reversed by 3-TYP. In addition, we found AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway might be activated by Honokiol but restrained by 3-TYP. These results indicated that Honokiol was capable of suppressing APE's adverse effects, which was diminished by SIRT3 suppression, implying that activation of SIRT3 might serve as a therapeutic method for APE.

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Section: Discussionmentioning

confidence: 99%

Sirtuin3 confers protection against acute pulmonary embolism through anti-inflammation, and anti-oxidative stress, and anti-apoptosis properties: participation of the AMP-activated protein kinase/mammalian target of rapamycin pathway

Han

Jia

et al. 2023

Exp. Anim.

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“…As a chronic vascular inflammatory disease, atherosclerosis has been demonstrated to exert immunomodulatory and immunosuppressive effects on MSCs by secreting humoral factors ( Takafuji et al, 2019 ). It has been reported that Sestrin2 is a stress-inducing protein that inhibits mTOR by activating AMPK ( Tian et al, 2021b ). Furthermore, Sestrin2 is strongly associated with atherosclerosis, suggesting that inhibition of mTOR signaling can be used to treat atherosclerosis ( Tian et al, 2021b ).…”

Section: The Mammalian Target Of Rapamycin Signaling Pathway In Mesen...mentioning

confidence: 99%

“…It has been reported that Sestrin2 is a stress-inducing protein that inhibits mTOR by activating AMPK ( Tian et al, 2021b ). Furthermore, Sestrin2 is strongly associated with atherosclerosis, suggesting that inhibition of mTOR signaling can be used to treat atherosclerosis ( Tian et al, 2021b ). In other words, mTOR is a target for the treatment of atherosclerosis.…”

Section: The Mammalian Target Of Rapamycin Signaling Pathway In Mesen...mentioning

confidence: 99%

Recent advances of the mammalian target of rapamycin signaling in mesenchymal stem cells

et al. 2022

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Mammalian target of rapamycin (mTOR) is a serine/threonine kinase involved in a variety of cellular functions, such as cell proliferation, metabolism, autophagy, survival and cytoskeletal organization. Furthermore, mTOR is made up of three multisubunit complexes, mTOR complex 1, mTOR complex 2, and putative mTOR complex 3. In recent years, increasing evidence has suggested that mTOR plays important roles in the differentiation and immune responses of mesenchymal stem cells (MSCs). In addition, mTOR is a vital regulator of pivotal cellular and physiological functions, such as cell metabolism, survival and ageing, where it has emerged as a novel therapeutic target for ageing-related diseases. Therefore, the mTOR signaling may develop a large impact on the treatment of ageing-related diseases with MSCs. In this review, we discuss prospects for future research in this field.

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“…NT proBNP has been more widely used than BNP in clinics because of its long half-life and good performance at particularly ruling out heart failure in breathless patients. Sestrin2 is a stress-induced antioxidant protein that counteracts oxidative stress, inhibits ischemia-reperfusion injury, and regulates and controls thrombosis [ 6 ]. Sestrin2 is involved in the pathogenesis of acute ischemic stroke, and the cardiac remodeling process [ 7 ], but whether sestrin2 affects the development and progression of heart disease is unknown [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of peripheral TiM-3, NT proBNP, and Sestrin2 testing in left-to-right shunt congenital heart disease with heart failure

et al. 2023

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Background Left-to-right shunt congenital heart disease is more likely to induce recurrent respiratory infections in the patients which exacerbate pulmonary hypertension and thereby impairs cardiac function. It is urgent to explore a non-invasive and accurate diagnostic method that can show the cardiac anatomy and associated malformations in clinical research. Objective To determine the diagnostic value of peripheral mucin domain protein-3 (Tim-3), N-terminal pro-brain natriuretic peptide (NT proBNP), sestrin2 testing in patients with the left-to-right shunt congenital heart disease and heart failure. Methods Fifty-two neonates with with left to right shunt congenital heart disease and 30 healthy neonates were enrolled. Blood samples were collected within 24 h of admission from newborns for determining the content of TiM-3, NT proBNP, and Sestrin2. Analyzing the ROC curve provided insight into the diagnostic accuracy. Both a Spearman’s rank correlation test and a logistic regression analysis were carried out. Results TiM-3, NT proBNP, and Sestrin2 levels in peripheral blood were statistically different in the three groups (P < 0.05). There were significant differences in LVEF and LVFS among the three groups (P < 0.05). When used to diagnose heart failure in conjunction with left-to-right shunt congenital heart disease, TiM-3, NT proBNP, and Sestrin2 exhibited sensitivity of 58.3, 58.3, and 83.3%, respectively, and specificity of 85.0, 72.5, and 70.0%. ROC curve analysis showed that the AUCs of Tim-3, NT proBNP, and sestrin2 in predicting the outcome of left-to-right shunted congenital heart disease combined with heart failure were 0.744 (95% CI, 0.580 to 0.908), 0.608 (95% CI, 0.359 to 0.857), respectively 0.744 (95% CI 0.592 to 0.896). Conclusion Tim-3, NT proBNP, and sestrin2 can accurately differentiate heart failure from non-combined heart failure from left-to-right shunt congenital heart disease.

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Sestrin2 in atherosclerosis

Cited by 3 publications

References 57 publications

Sirtuin3 confers protection against acute pulmonary embolism through anti-inflammation, and anti-oxidative stress, and anti-apoptosis properties: participation of the AMP-activated protein kinase/mammalian target of rapamycin pathway

Sirtuin3 confers protection against acute pulmonary embolism through anti-inflammation, and anti-oxidative stress, and anti-apoptosis properties: participation of the AMP-activated protein kinase/mammalian target of rapamycin pathway

Recent advances of the mammalian target of rapamycin signaling in mesenchymal stem cells

Diagnostic value of peripheral TiM-3, NT proBNP, and Sestrin2 testing in left-to-right shunt congenital heart disease with heart failure

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