Sestrin1, 2, and 3 are dispensable for female fertility in mice
Mengchen Wang,
Wenhui Chen,
Xinxin Zeng
et al.
Abstract:Background
Sestrins have been implicated in regulating aging in various organs through multiple pathways. However, their roles in ovarian aging remain unrevealed.
Methods
Female Sestrin1−/−, Sestrin2−/−, and Sestrin3−/− mice were generated using the CRISPR-Cas9 system. Body weights, little sizes, ovarian weights, estrous cyclicity, and follicle number in female mice were observed. ELISA was utilized to measure serum anti-Müllerian hormone (AMH) lev… Show more
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