Session 4: Primary practice and the profession; PetSavers student grants: 2020 awards

Abstract

The efficacy of a novel oral endectocide containing moxidectin, sarolaner and pyrantel was investigated in client-owned dogs with natural infections of Toxocara canis, Toxascaris leonina, Ancylostoma caninum and Uncinaria stenocephala. MethodsDogs infected with any of the four gastrointestinal nematode species were enrolled in this controlled, masked, randomized study. In total, 194 dogs were treated once orally with the combination of sarolaner (1.2 to 2.4 mg/kg), moxidectin (24 to 48 µg/kg) and pyrantel (5 to 10 mg/kg) and 97 dogs were treated with a positive control product containing afoxolaner (2.50-5.36 mg/kg) and milbemycin oxime (0.50-1.07 mg/kg). Faecal egg counts were conducted before, and 7 days after treatment administration. Efficacy was based on the post-treatment reduction in geometric mean egg counts (per gram faeces) compared to pre-treatment. ResultsTwo hundred dogs were infected with T. canis, 80 with A. caninum, 36 with U. stenocephala, and 16 with T. leonina. Fifty dogs had mixed infections with two or more species. Post-treatment geometric mean fecal egg counts for T. canis, A. caninum, T. leonina, and U. stenocephala relative to pretreatment counts were significantly (P<0.0001) reduced by ≥98.3% in the group treated with the combination of sarolaner, moxidectin and pyrantel, and by ≥ 97.4% in the afoxolaner and milbemycin oxime-treated group. Both products were well tolerated. Statement (conclusions)Oral administration of the combination of 1.2 mg/kg sarolaner, 24 µg/kg moxidectin and 5.0 mg/kg pyrantel provided effective treatment of roundworm and hookworm infection in dogs.