Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on ‘Nutrition and autoimmune disease’ Nutrition in Crohn's disease

O’Sullivan, Maria

doi:10.1017/s0029665109001025

Cited by 21 publications

(10 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies have suggested that Vitamin D status plays an important role in the initiation, progression and/or severity of different autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, asthma, systemic lupus erythematous and inflammatory bowel disease (IBD) [ 2 , 124 , 125 , 126 , 127 , 128 , 129 , 130 ]. IBD such as Crohn’s disease and ulcerative colitis, are chronic, idiopathic inflammatory disorders of the gastrointestinal tract [ 131 ].…”

Section: Implications For Human Diseasementioning

confidence: 99%

Regulation of Dendritic Cell Function by Vitamin D

2015

View full text Add to dashboard Cite

Studies over the last two decades have revealed profound immunomodulatory aspects of vitamin D on various aspects of the immune system. This review will provide an overview of Vitamin D metabolism, a description of dendritic cell subsets, and highlight recent advances on the effects of vitamin D on dendritic cell function, maturation, cytokine production and antigen presentation. The active form of vitamin D, 1,25(OH)2D3, has important immunoregulatory and anti-inflammatory effects. Specifically, the 1,25(OH)2D3-Vitamin D3 complex can affect the maturation and migration of many dendritic cell subsets, conferring a special immunoregulatory role as well as tolerogenic properties affecting cytokine and chemokine production. Furthermore, there have been many recent studies demonstrating the effects of Vitamin D on allergic disease and autoimmunity. A clear understanding of the effects of the various forms of Vitamin D will provide new opportunities to improve human health.

show abstract

Section: Implications For Human Diseasementioning

confidence: 99%

Regulation of Dendritic Cell Function by Vitamin D

2015

View full text Add to dashboard Cite

show abstract

“…Weight loss and malnutrition are well-documented features of CD, affecting an estimated 80% of patients during acute flare-ups and hospital admissions [3][4][5] and are associated with higher mortality, 3 longer hospital stays and higher health care costs. 4 Paradoxically, overweight is now emerging as a further nutritional issue affecting people with CD.…”

Section: Introductionmentioning

confidence: 99%

High prevalence of overweight and obesity in adults with Crohn's disease: Associations with disease and lifestyle factors

Suibhne

Raftery

McMahon

et al. 2013

Journal of Crohn's and Colitis

Self Cite

130

View full text Add to dashboard Cite

Background and aims: Obesity and overweight are major public health issues. Although traditionally associated with weight loss, there is now evidence that increasing Body Mass Index (BMI) and overweight are emerging features of Crohn's disease (CD) and may be associated with more severe disease course. The aim of the study was to determine the prevalence of overweight and obesity in patients with CD compared with matched healthy controls and to identify disease-specific and generic factors associated with current BMI in this group. Methods: This was a prospective case-control study (n=200), comprising 100 CD outpatients and 100 age-, sex-and socioeconomically-matched healthy controls. BMI, Crohn's disease activity index (CDAI), clinical and lifestyle factors and circulating inflammatory markers were assessed. Results: Overall, 40% of patients with CD were overweight/obese (BMI ≥25 kg/m 2 ) compared with 52% of controls (P =0.206). On regression analysis, higher current BMI was significantly associated with disease specific factors, namely lower disease activity (CDAI) and lower white cell count, suggesting stable disease, as well as older age and lower physical activity. BMI was not significantly associated with the need for surgery or the need for corticosteroids. We identified a novel association between higher BMI and higher CRP, a marker linked both with obesity in the general population and with CD. Conclusions: Overweight was common in out-patients with CD and appeared to reflect current wellness, older age and sedentary lifestyles. The potential long-term implications of high BMI for CRP and inflammatory load merit further study.

show abstract

“…Micronutrient deficiencies are essentially explained by the reduced dietary intake and the underlying malabsorption. They have been associated with prolonged hospitalization and higher mortality [69].…”

Section: Disease Specific Deficiencymentioning

confidence: 99%

Micronutrient Deficiencies in Medical and Surgical Inpatients

Berger

Pantet

Schneider

et al. 2019

JCM

View full text Add to dashboard Cite

Inpatients are threatened by global malnutrition, but also by specific micronutrient (i.e., trace element and vitamins) deficiencies that frequently are overseen in the differential diagnosis of major organ dysfunctions. Some of them are related to specific geographic risks (iodine, iron, selenium, zinc, vitamin A), while others are pathology related, and finally many are associated with specific feeding patterns, including low dose enteral feeding. Among the pathologies in which laboratory blood investigations should include a micronutrient outwork, anemia is in the front line, followed by obesity with bariatric surgery, chronic liver disease, kidney disease, inflammatory bowel disease, cardiomyopathies and heart failure. The micronutrients at the highest risk are iron, zinc, thiamine, vitamin B12 and vitamin C. Admission to hospital has been linked with an additional risk of malnutrition—feeding below 1500 kcal/day was frequent and has been associated with a structural additional risk of insufficient micronutrient intake to cover basal needs. Although not evidence based, systematic administration of liberal thiamine doses upon admission, and daily complementation of inpatients’ food and enteral feeding solutions with multi-micronutrient tablets might be considered.

show abstract

Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on ‘Nutrition and autoimmune disease’ Nutrition in Crohn's disease

Cited by 21 publications

References 82 publications

Regulation of Dendritic Cell Function by Vitamin D

Regulation of Dendritic Cell Function by Vitamin D

High prevalence of overweight and obesity in adults with Crohn's disease: Associations with disease and lifestyle factors

Micronutrient Deficiencies in Medical and Surgical Inpatients

Contact Info

Product

Resources

About