Sesquiterpenoids from the Root Bark of Acanthopanax leucorrhizus and Their Biological Activities

Abstract

Three furoeremophilane‐type sesquiterpenoids, including one new, 1α‐acetoxy‐6β‐(benzoyloxy)‐10β‐hydroxy‐9‐oxofuroeremophilane (1), and two known, 1β,6β‐diacetoxy‐9‐oxofuroeremophilane (2) and (6α)‐furoeremophilan‐14,6‐olide (3), were isolated from the root bark of Acanthopanax leucorrhizus from China. Their structures were elucidated on the basis of comprehensive spectroscopic analyses, including IR, HR‐ESI‐MS, 1D‐ and 2D‐NMR experiments. A preliminary bioassay revealed that compound 1 exhibits weak cytotoxicities against the human tumor cell lines MCF‐7 and SMMC‐7721 with the IC50 values of 75.12±1.69 and 168.36±2.01 μg/ml, respectively. Compound 1 and 2 showed moderate activities against Escherichia coli with the MIC values of 32 and 64 μg/ml, respectively.

Cumulative Data of1H and13C NMR Signals and Specific Rotations of Eremophilane Sesquiterpenoids. 3. 10H-Furanoeremophilanes Without 3-O Functionality

“…Compounds 111 , 112 , and 114 have 1α-hydroxy, 58,60 and 113 1β-acetoxy groups. 64,65 Compounds 98 (Table 23) and 111 , 99 (Table 23) and 112 , and 101 (Table 23) and 114 are C-10 epimers, respectively. Concerning the configuration of C-1 of compound 111 , it is quite doubtful.…”