Sesquiterpenes Isolated from <i>Aspergillus fumigatus</i>, an Endophytic Fungus from <i>Ligusticum wallichii</i>

Li, Xiaohua; Hu, H.X.; Tan, Lu; Wu, Wenlin; Cao, Zhixing; Gu, Yu‐Cheng; Deng, Yun; Guo, Da‐Le

doi:10.1177/1934578x1801301101

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…It is quite shocking that almost 20% of yield reductions in the cash crops and major food worldwide were caused by phytopathogenic fungi, despite the continued release of new antifungal agents and resistant cultivars every year. − Agrochemicals from natural products have been proved to be an effective strategy used in control of phytopathogenic fungi . Microorganisms have been regarded as a promising resource with the most potential for structurally novel antifungal metabolites because of the isolation of many natural fungicides from the microbial resource, including blasticidin-S, validamycin, polyoxins, and kasugamycin. − Endophytic fungi are microorganisms that asymptomatically invade the intercellular spaces of plant tissues. The symbiosis between endophytic fungi and hosts causes some endophytic fungi to produce bioactive substances to protect their hosts from plant pathogen attacks or enhance the host growth. − Therefore, these endophytic fungi might have the potential to be the sources of new bioactive compounds of agricultural and pharmaceutical importance.…”

Section: Introductionmentioning

confidence: 99%

Antifungal Halogenated Cyclopentenones from the Endophytic Fungus Saccharicola bicolor of Bergenia purpurascens by the One Strain-Many Compounds Strategy

Zhao

Guo

Liu

et al. 2019

J. Agric. Food Chem.

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Phytopathogenic fungi have been considered as being an enormous threat in the agricultural system. In our search of new antifungal natural products, nine new halogenated cyclopentenones, bicolorins A–I (1–3, and 5–10), along with three known cyclopentenones (4, 11, and 12) were isolated from the endophytic fungus Saccharicola bicolor of Bergenia purpurascens by the one strain-many compounds strategy. Their structures and absolute configurations were elucidated based on extensive spectroscopic analysis, X-ray crystallographic analysis, and time-dependent density functional theory–equivalent circulating density calculations. Compounds 1–12 showed antifungal activities against five phytopathogenic fungi (Uromyces viciae-fabae, Pythium dissimile, Gibberella zeae, Aspergillus niger, and Sclerotinia sclerotiorum). Especially, bicolorins B and D (2 and 5) exhibited strong antifungal activities against P. dissimile with the MIC values of 6.2 and 8.5 μg/mL, respectively, compared with the positive control cycloheximide (MIC of 8.6 μg/mL). Additionally, bicolorin D was proven to be potently antifungal against S. sclerotiorum in vitro and in vivo. This work provides an effective strategy for searching antifungal candidate agents.

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Section: Introductionmentioning

confidence: 99%

Antifungal Halogenated Cyclopentenones from the Endophytic Fungus Saccharicola bicolor of Bergenia purpurascens by the One Strain-Many Compounds Strategy

Zhao

Guo

Liu

et al. 2019

J. Agric. Food Chem.

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“…The TDDFT ECD calculations of compounds 3 , 4 , and 7 were conducted using Gaussian 16 software according to the reported method. − The detailed procedures are shown in the Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

Flavonoids with Inhibitory Effects on NLRP3 Inflammasome Activation from Millettia velutina

Zhao

Tang

et al. 2020

J. Nat. Prod.

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Eight new flavonoids, including two β-hydroxy/methoxychalcones, velutones A and B (1 and 2), two 1,3-diarylpropan-1-ols, velutols C and D (3 and 4), a dihydroxychalcone, velutone E (5), a chalcone, velutone F (6), a furanoflavanone, velutone G (7), and a furanoflavonol, velutone H (8), and 14 known compounds were isolated from Millettia velutina. Their structures were determined by high-resolution electrospray ionisation mass spectrometry (HR-ESIMS) and spectroscopic data analyses and time-dependent density functional theory electronic circular dichroism (TD-DFT–ECD) calculations. Among the isolated constituents, compound 6 exhibited the most potent inhibitory effect (IC50: 1.3 μM) against nigericin-induced IL-1β release in THP-1 cells. The initial mechanism of action study revealed that compound 6 suppressed NLRP3 inflammasome activation via blocking ASC oligomerization without affecting the priming step, which subsequently inhibited caspase-1 activation and IL-1β secretion. Most importantly, compound 6 exerted potent protective effects in the LPS-induced septic shock mice model by improving the survival rate of mice and suppressing serum IL-1β release. These results demonstrated that compound 6 had the potential to be developed as a broad-spectrum NLRP3 inflammasome inhibitor for the treatment of NLRP3-related disease.

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Sesquiterpenes Isolated from Aspergillus fumigatus, an Endophytic Fungus from Ligusticum wallichii

Cited by 2 publications

References 6 publications

Antifungal Halogenated Cyclopentenones from the Endophytic Fungus Saccharicola bicolor of Bergenia purpurascens by the One Strain-Many Compounds Strategy

Antifungal Halogenated Cyclopentenones from the Endophytic Fungus Saccharicola bicolor of Bergenia purpurascens by the One Strain-Many Compounds Strategy

Flavonoids with Inhibitory Effects on NLRP3 Inflammasome Activation from Millettia velutina

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