Sesquiterpene lactones of Xanthium species. Xanthanol and isoxanthanol, and correlation of xanthinin with ivalbin

Winters, Thomas; Geissman, T. A.; Safir, David

doi:10.1021/jo00838a033

Cited by 42 publications

(50 citation statements)

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“…xanthinin; its stereoisomer, xanthumin, xanthatin (deacetylxanthinin); a toxic principle, a sulphated glycoside: xanthostrumarin, atractyloside, carboxyatractyloside; phytosterols, xanthanol, isoxanthanol, xanthinosin, 4-oxo-bedfordia acid, hydroquinone; xanthanolides [44][45][46][47] ; caffeoylquinic acids; α and γ-tocopherol [48] ; thiazinedione [49] ; 4-oxo-1(5),2,11,(13)-xanthatriene-12,8-olide, known as "deacetyl xanthumin" an antifungal compound. The main toxic compound isolated from the plant has been identified as carboxyatractyloside, a kaurene glycoside previously called xanthostrumarium.…”

Section: Chemical Constituentsmentioning

confidence: 99%

A Review on Medicinal Plants Used as Diuretics From Karnataka State

Paarakh¹

2017

WJPPS

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Medicinal herbs are the significant source for treatment of number of diseases, one such is Diuretics. Mono and poly-herbal preparations have been used as diuretics. According to estimate, more than 650 mono and poly-herbal preparations in the form of decoction, tincture, tablets and capsules are from more than 75 plants that are in clinical use. There exist a large number of studies which supports the diuretic effects of traditional herbal medicines. Herbal medicine have been the most commonly prescribed medications for diuretics. They inhibit electrolyte reabsorption from the lumen of the nephron, increasing osmolarity, enhancing water and electrolyte excretion. It is important to note that there is a delicate balance between dietary sodium intake and sodium loss. If the balance is compromised and there is a greater intake of sodium into the body, but not enough sodium removal, complications of fluid overload occur, such as oedema, pulmonary oedema or high blood pressure. When there is greater removal of sodium, but not enough sodium intake, complications of fluid depletion take place, such as renal failure or reduced output of blood from the heart. The ability to induce a negative fluid balance has made diuretics useful in the treatment of a variety of conditions, particularly in hypertension and oedematous states. This review gives information about few herbal plants which are used traditionally in Karnataka as diuretics. There are a large number of studies which supports the diuretic effects of traditional herbal medicines which is presented along with chemical constituents and other pharmacological action of the plants.

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Section: Chemical Constituentsmentioning

confidence: 99%

A Review on Medicinal Plants Used as Diuretics From Karnataka State

Paarakh¹

2017

WJPPS

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“…Besides alkaloids, the aerial parts of the plant contain sesquiterpene lactones, viz. xanthinin; its stereoisomer, xanthumin, xanthatin (deacetylxanthinin); a toxic principle, a sulphated glycoside: xanthostrumarin, atractyloside, carboxyatractyloside; phytosterols, xanthanol, isoxanthanol, xanthinosin, 4-oxo-bedfordia acid, hydroquinone; xanthanolides; [22][23][24][25][26] caffeoylquinic acids; α and γ-tocopherol; [27] thiazinedione, [28] 4-oxo-1(5),2,11,(13)-xanthatriene-12,8-olide, known as "deacetyl xanthumin" an antifungal compound; linoleic acid. The main toxic compound isolated from the plant has been identified as carboxyatractyloside, a kaurene glycoside previously called xanthostrumarium.…”

Section: Chemical Constituentsmentioning

confidence: 99%

Phytopharmacological review ofXanthium strumarium L.(Cocklebur)

Kamboj¹,

Saluja²

2010

Int J Green Pharm

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and hotter parts of India. The herb is traditionally used mostly in treating several ailments. Extracts of the whole plant, especially leaves, roots, fruits and seeds have been applied in traditional medicine for the treatment of leucoderma, poisonous bites of insects, epilepsy, salivation, long-standing cases of malaria, rheumatism, tuberculosis, allergic rhinitis, sinitis, urticaria, rheumatoid arthritis, constipation, diarrhoea, leprosy, lumbago, pruritis, bacterial and fungal infections. This comprehensive account provides a botanical description of the plant, its phytochemical constituents and pharmacological activities are reviewed, focussing on antibacterial, antitumour, antitussive, antifungal, antiinflammatory, antinociceptive, hypoglycaemic, antimitotic, antioxidant, antitrypanosomal, CNS depressant activity, diuretic effects, contact dermatitis, insecticidal and herbicidal activities. Most of the pharmacological effects can be explained by the constituents like sesquiterpene lactones, glycoside, phenols, polysterols present in all plant parts. However, future efforts should concentrate more on in vitro and in vivo studies and also on clinical trials in order to confirm traditional wisdom in the light of a rational phytotherapy. Because of its multi-activity, in particular, anti-tumour, anti-cancer activity, so much attention is focussed on the herb. Finally, research needs quantitation of individual constituents and assessment of their pharmacological activities in humans.

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“…Previous chemical investigation has resulted in the isolation of four ent-kaurene diterpenoids (2). Our recent study of this plant led to the isolation of two new diterpenoids (1,2) and two derivatives of shikokianin (3, 4) together with six known diterpenoids, longikaurins 0-F (3, 4), effusanin D (5) (5), shikokianin (7) (6), and rabdolasional (7), and one known norisoprenoid, blumenol A (8,9), all being isolated for the first time from this plant. Compound I was determined as C25H34010 (IMJ m/z 506.2157) by HRMS.…”

Section: Ilczl3-dihydroxyxanthatinmentioning

confidence: 99%

“…Widd, collected in Egypt. Previous chemical investigations of these species showed that xanthanolide sesquiterpene lactones were the characteristic constituents (4)(5)(6)(7)(8)(9). In the present work, a new xanthanolide diol derivative, lla,13-dihydroxyxanthatin and a new dimeric xanthanolide, pungiolide C, in addition to the known compounds, xanthatin (5, 9), 8-epixarithatin (10), and pungiolide A (1) were isolated.…”

mentioning

confidence: 99%

A Xanthanolide Diol and a Dimeric Xanthanolide fromXanthiumSpecies

Ahmed¹,

Mahmoud²,

El‐Gamal³

1999

Planta Med

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Extracts of the aerial parts of Xanthium strumarium and fruit of X. pungens afforded a new Xanthanolide diol derivative, 11alpha,13-dihydroxyxanthatin and a new dimeric xanthanolide sesquiterpene lactone, pungiolide C, in addition to some known compounds. The structures of the new compounds were determined by spectroscopic methods particularly high resolution (1)H-, (13)C-NMR and 2D (1)H- (1)H and (1)H- (13)C COSY NMR analysis.

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Sesquiterpene lactones of Xanthium species. Xanthanol and isoxanthanol, and correlation of xanthinin with ivalbin

Cited by 42 publications

References 0 publications

A Review on Medicinal Plants Used as Diuretics From Karnataka State

A Review on Medicinal Plants Used as Diuretics From Karnataka State

Phytopharmacological review ofXanthium strumarium L.(Cocklebur)

A Xanthanolide Diol and a Dimeric Xanthanolide fromXanthiumSpecies

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