Sesquiterpene Lactones of Calea divaricata and the Molecular Structure of Leptocarpin Acetate

Ober, Alfonso G.; Fronczek, Frank R.; Fischer, Nikolaus H.

doi:10.1021/np50038a017

Cited by 14 publications

(9 citation statements)

References 9 publications

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“…The assignment of 1H-NMR signals was performed by a frequency swept decoupling experiment. The results of our recents studies in solution show agreements with the single crystal X-ray diffraction studies performed by Ober et al (6).…”

supporting

confidence: 92%

Conformational Analysis and Biological Activity of Leptocarpin and Leptocarpin Acetate

et al. 1995

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Letters a group of PAHs are present in the plant extract and contributed to the light-mediated antiviral activity. We believe that the source of the PAHs was not from contamination in the purification procedure. With separation and analytical techniques capable of purifying trace components, it is more of a possibility that impurities from materials used in the processing can be accumj.ilated and be found in an identifiable quantity. The major solvent used in this procedure consisted of a mixture of hexanes. The impurities remaining from the evaporation of four liters of hexanes under reduced pressure were submitted for NMR and the spectrum obtained was not complex enough to indicate the presence of PAHs. Polycycic aromatic hydrocarbons have been found in foliage as well as in crops (6). PAils are generated by the incomplete combustion of fossil fuels and are found throughout the environment. If the occurrence of 245-261.

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confidence: 92%

Conformational Analysis and Biological Activity of Leptocarpin and Leptocarpin Acetate

et al. 1995

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“…This is also true for the solid-state structure derived from x-ray data for 1 9 and for other heliangolides. 22,23 Cyclodecane derivatives in such a conformation are known to have considerable mobility, but the lack of flexibility in the structure of furanoheliangolides may be attributed to the presence of the dihydrofuranone ring. The calculated dihedral angles are similar to those obtained for the crystal as shown in Table 2.…”

Section: Resultsmentioning

confidence: 99%

Reassignment of NMR spectra and conformational study of the sesquiterpene lactone goyazensolide

Perry

Miguez

Amorim

et al. 2001

Magnetic Reson in Chemistry

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“…sp., Calea lantanoides Gardner, Calea angusta S.F. Blake, Calea teucrifolia , and Calea hymenolepis Baker (Bohlmann, Fritz, King, & Robinson, ; Bohlmann, Gupta, King, & Robinson, , b; Bohlmann, Mathur, et al, ; Bohlmann, Zdero, King, & Robinson, ; Ober, Fronczek, & Fischer, ; Vichnewski, Goulart, & Herz, ).…”

Section: Chemical Constituentsmentioning

confidence: 99%

“…Flavonoid profile of Calea plants consisted of four chalcones (192–195), one isoflavone (196), one flavonone (197), five O ‐heteroside flavonoids (198–202), and seven flavones (203–209). Genkwanin (204), 7‐ O ‐methylacacetin (205), and acacetin (206) are the major aglycone flavones in Calea (Chaurasiya et al, ; Do Nascimento, et al, ; Do Nascimento, Salvador, Candido, Ito, et al, ; Herz & Kumar, ; Kohler et al, ; Martinez, Naveda‐Diaz, & Joseph‐Nathan, ; Martinez, Sanchez, & Joseph‐Nathan, ; Ober et al, ; Ober & Fischer, ; Ober, Fischer, & Parodi, ; Ober, Urbatsch, & Fischer, ; Ortega, Lopez, & Maldonado, ).…”

Section: Chemical Constituentsmentioning

confidence: 99%

“…(Lourenço, Akisue, & Roque, 1981). Genkwanin (204), 7-O-methylacacetin (205), and acacetin (206) are the major aglycone flavones in Calea (Chaurasiya et al, 2016;Kohler et al, 2002;Martinez, Naveda-Diaz, & Joseph-Nathan, 1988;Martinez, Sanchez, & Joseph-Nathan, 1987;Ober et al, 1985b;Ober, Fischer, & Parodi, 1986;Ober, Urbatsch, & Fischer, 1985a;Ortega, Lopez, & Maldonado, 1989).…”

Section: Chromones and Chromanonesmentioning

confidence: 99%

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The genus Calea L.: A review on traditional uses, phytochemistry, and biological activities

Lima

Souza

Silva

et al. 2018

Phytotherapy Research

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Calea L. is a genus of shrubs and perennial herbs belonging to Asteraceae family. It is a very well‐known genus, consisting of approximately 125 neotropical species. Calea genus is a rich source of phytochemicals, and some of its species have been used in folk medicine to treat several health problems such as diabetes, arterial hypertension, respiratory and gastrointestinal disorders, gastric ulcers, and inflammation. Many studies have demonstrated the pharmacological potential of this genus, including antinociceptive, antihypertensive, antidiarrheal, antimicrobial, anti‐inflammatory, antidiabetic, antiproliferative, and cytotoxic activities. Moreover, bioactive constituents related to these properties are mainly sesquiterpene lactones and phenolic derivatives. In this review, we compiled the literature data up to December 2016, furnishing a comprehensive survey about medicinal uses, chemistry, and biological activities from Calea species. Bibliographic search was performed in several search engines using “Calea” as search keyword. Further, a manual literature search of references found in the selected studies was also conducted. There was no initial time limit.

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Sesquiterpene Lactones of Calea divaricata and the Molecular Structure of Leptocarpin Acetate

Cited by 14 publications

References 9 publications

Conformational Analysis and Biological Activity of Leptocarpin and Leptocarpin Acetate

Conformational Analysis and Biological Activity of Leptocarpin and Leptocarpin Acetate

Reassignment of NMR spectra and conformational study of the sesquiterpene lactone goyazensolide

The genus Calea L.: A review on traditional uses, phytochemistry, and biological activities

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