Sesquiterpene lactones from Schkuhria pinnata

Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata

“…The structures of all the compounds were determined by analysis of their NMR (1D and 2D) and HR/MS data. For the previously known compounds, eupatoriopicrin ( 4 ), 3β-hydroxy-8β-[5′-hydroxy-4′-(2″-hydroxy­isovaleroyloxy)­tigloyloxy]­costunolide ( 5 ), 3β-hydroxy-8β-[4′-hydroxytigloyloxy]­costunolide ( 6 ), 3β-hydroxy-8β-[5′-hydroxy-4′-(2″-hydroxy-3″-methylvaleroyloxy)­tigloyloxy]­costunolide ( 7 ), eucannabinolide ( 8 ), schkuhrin II ( 9 ), 2′(3′)- Z -eucannabinolide ( 10 ), 2″-dehydroeucannabinolide­semiacetal ( 11 ), hiyodorilactone B ( 12 ), santhemoidin A ( 13 ), 3-desacetyl-3-isovaleroyleucannabinolide ( 15 ), 1β,10α-epoxyeucannabinolide ( 17 ), schkuripinnatolide A ( 18 ), schkuripinnatolide C ( 19 ), 6α,14-dihydroxy-11βH,4 E ,1­(10) E -germacradiene-8,12-olide ( 20 ), 6α-hydroxy-14-oxo-11βH,4 E ,1­(10) E -germacradiene-8,12-olide ( 21 ), 3-oxo-4β,15-dihydroliqustrin-[4′,5′-dihydroxytigloyloxy] ( 22 ), 8β-[4′,5′-dihydroxytigloyloxy]­preeupatundin ( 23 ), pectolinarigenin ( 24 ), and 3-hydroxy-4,5-dimethoxybenzenepropanol ( 25 ), all analytical data obtained were in full agreement with those reported in the literature.…”

Medicinal plants used in the management of chronic joint pains in Machakos and Makueni counties, Kenya

“…Leaves used for coughs, stomach pains and decoction of whole plant used to treat small pox as a bath (Kokwaro, 1993;Schlage et al, 2000) Salvadora persica (Salvadoraceae) Antibacterial activity; alkaloid salvadorine (Almas and Al-Bagieh, 1999) Root decoction used to cure abdominal pains, chest diseases, wounds and young stems used as toothbrush (Kokwaro, 1993) Schkuhria pinnata (Asteraceae) Antibacterial, anti-inflammatory activities (Luseba et al, 2007). Isolated compounds include sesquiterpene lactones, heliangolides, germacranolide, schkuhripinnatolide C and pectolarigenin (Pacciaroni et al, 1995) Plant used in treating joint, chest and abdominal pains (Kokwaro, 1993); abortifacient and contraceptive (Van Wyk and Gericke, 2000)…”

New Melampolides from Schkuhria schkuhrioides

“…Species belonging to the genus Schkuhria are known sources of sesquiterpene lactones, − diterpenes, polyacetylenes, and other constituents. , Some species and their varieties are used in traditional medicine, , and different biological activities have been reported for some constituents. , Previous papers have reported a series of melampolides, , elemanolides, , and flavonoids from the aerial parts of S. schkuhrioides (Link & Otto) Thellung (Compositae). We have now characterized additional sesquiterpene lactones from this source, and the antimicrobial and cytotoxic activities of some melampolides were evaluated.…”

“…Species belonging to the genus Schkuhria 1 are known sources of sesquiterpene lactones, [2][3][4][5][6] diterpenes, 7 polyacetylenes, and other constituents. 8,9 Some species and their varieties are used in traditional medicine, 1,2 and different biological activities have been reported for some constituents.…”